Organic Letters,
Год журнала:
2024,
Номер
26(3), С. 607 - 612
Опубликована: Янв. 11, 2024
An
electrochemical
approach
to
biheteroaryls
through
the
coupling
of
diverse
N-heteroarenes
with
heteroaryl
phosphonium
salts
is
reported.
The
reaction
features
pH
and
redox-neutral
conditions
excellent
regioselectivity,
as
well
exogenous
air
or
moisture
tolerance.
Additionally,
a
one-pot,
two-step
protocol
can
be
established
realize
formal
C–H/C–H
heteroarenes,
thereby
greatly
expanding
substrate
availability.
utility
this
method
demonstrated
late-stage
functionalization,
total
synthesis
nitraridine,
antifungal
activity
studies.
Organic Process Research & Development,
Год журнала:
2024,
Номер
28(2), С. 338 - 366
Опубликована: Янв. 18, 2024
This
review
summarizes
examples
of
organic
electrosynthesis
from
the
peer-reviewed
literature
2000
to
2023
that
have
been
conducted
on
scales
20
g
or
above.
A
significant
portion
these
were
a
≤100
scale,
while
detailed
reports
kilogram-scale
remain
scarce
in
pharmaceutical
industry.
In
addition
chemical
transformation,
this
also
highlights
type
reactor
used
and
projected
productivity
metric
as
ways
compare
different
reports.
The
selected
scale-ups
described
herein
illustrate
remaining
challenges
currently
preventing
routine
use
large-scale
Chemical Science,
Год журнала:
2024,
Номер
15(23), С. 8606 - 8624
Опубликована: Янв. 1, 2024
Electrochemistry
shows
promising
new
avenues
in
the
recycling
of
polymeric
materials.
This
work
reviews
electrochemical
depolymerization,
post-polymerization
functionalization,
and
paired
catalysis,
highlighting
future
challenges
opportunities.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(15), С. 4318 - 4342
Опубликована: Янв. 1, 2024
This
review
primarily
focuses
on
the
generation
of
aryl
radicals
via
an
electroreduction
strategy,
and
systematically
elaborates
synthetic
applications,
scope,
limitations
substrates.
Chemical Society Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
highlights
organo-mediators
that
enable
electrochemical
reactions
via
outer-sphere
electron
transfer
(ET),
offering
advantages
such
as
availability,
tunability,
and
simplified
post-processing
compared
to
direct
electrolysis.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(22), С. 5735 - 5745
Опубликована: Янв. 1, 2023
During
the
past
decade,
photo-
and
electrochemical
reactions
proceeding
via
single-electron-transfer
(SET)
triggered
radical
pathways
have
emerged
as
an
indispensable
strategy
for
efficient
formation
of
chemical
bonds.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Дек. 13, 2023
An
electroreductive
strategy
for
radical
hydroxyl
fluorosulfonylation
of
alkenes
with
sulfuryl
chlorofluoride
and
molecular
oxygen
from
air
is
described.
This
mild
protocol
displays
excellent
functional
group
compatibility,
broad
scope,
good
scalability,
providing
convenient
access
to
diverse
β-hydroxy
sulfonyl
fluorides.
These
fluoride
products
can
be
further
converted
valuable
aliphatic
fluorides,
β-keto
β-alkenyl
Further,
some
these
showed
inhibitory
activity
against
Botrytis
cinerea
or
Bursaphelenchus
xylophilus,
which
could
useful
potent
agrochemical
discovery.
Preliminary
mechanistic
studies
indicate
that
this
transformation
achieved
through
rapid
O2
interception
by
the
alkyl
subsequent
reduction
peroxy
radical,
outcompete
other
side
reactions
such
as
chlorine
atom
transfer,
hydrogen
Russell
fragmentation.
Hybrid Advances,
Год журнала:
2024,
Номер
6, С. 100268 - 100268
Опубликована: Авг. 1, 2024
Control
of
redox
processes
at
the
molecular
level
is
central
to
synthesis,
and
electrochemistry
provides
a
unique
means
directing
electron
flow
for
chemical
transformations.
Although
chemistry
community
has
long
recognized
its
power,
potential
electrochemical
methods
in
organic
synthesis
not
been
nearly
as
exploited
academically
or
industrially.
In
this
respect,
review
related
applying
nano-photocatalysts
fine
producing
compounds
presented.
The
existing
laboratory
industrial
are
too
resource-intensive,
mostly
based
on
non-renewable
energy
sources,
often
require
extreme
conditions
regarding
temperature
pressure.
review,
we
emphasize
forward
transformations
realizable
with
help
such
nanomaterials
under
UV/visible
light
exposure.
Nanophotocatalysts
thus
offer
huge
green
high-value-added
organics.
This
outlines
organics
nanophotocatalysts,
graphene
semiconductors,
titanium
oxide,
quantum
dots,
carbon-based
catalysts.
aims
present
current
research
field
provide
an
impetus
helpers
further
build
area
social
impact.
For
first
time,
all-inclusive
approach
helps
bridge
gaps
between
these
different
areas
view
challenges
electro-organic
photocatalysis.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(7)
Опубликована: Дек. 21, 2023
Abstract
Catalytic
hydrogenation
of
nitriles
represents
an
efficient
and
sustainable
one‐step
synthesis
valuable
bulk
fine
chemicals.
We
report
herein
a
molecular
cobalt
electrocatalyst
for
selective
hydrogenative
coupling
with
amines
using
protons
as
the
hydrogen
source.
The
key
to
success
this
reductive
reaction
is
use
electrocatalytic
approach
cobalt‐hydride
generation
through
sequence
cathodic
reduction
protonation.
As
only
electrons
(e
−
)
(H
+
redox
equivalent
source,
general
electrohydrogenation
protocol
showcased
by
highly
straightforward
various
functionalized
structurally
diverse
amines,
well
deuterium
isotope
labeling
applications.
Mechanistic
studies
reveal
that
electrogenerated
transfer
nitrile
process
rate‐determining
step.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(8), С. 2283 - 2288
Опубликована: Янв. 1, 2024
An
electrochemical
thiocyanation
of
distal
C(sp
3
)–H
bonds
based
on
amidyl
radical-mediated
1,5-HAT
has
been
developed.
The
transformation
is
highly
site-selective
and
compatible
with
primary,
secondary,
tertiary
sulfonamides,
bioactive
derivatives.
