Nature Communications, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 25, 2025
Язык: Английский
Organic Process Research & Development, Год журнала: 2024, Номер 28(2), С. 338 - 366
Опубликована: Янв. 18, 2024
This review summarizes examples of organic electrosynthesis from the peer-reviewed literature 2000 to 2023 that have been conducted on scales 20 g or above. A significant portion these were a ≤100 scale, while detailed reports kilogram-scale remain scarce in pharmaceutical industry. In addition chemical transformation, this also highlights type reactor used and projected productivity metric as ways compare different reports. The selected scale-ups described herein illustrate remaining challenges currently preventing routine use large-scale
Язык: Английский
Процитировано
44
Chemical Science, Год журнала: 2024, Номер 15(23), С. 8606 - 8624
Опубликована: Янв. 1, 2024
Electrochemistry shows promising new avenues in the recycling of polymeric materials. This work reviews electrochemical depolymerization, post-polymerization functionalization, and paired catalysis, highlighting future challenges opportunities.
Язык: Английский
Процитировано
12
The Chemical Record, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Abstract Owing to their wide utilizations in synthesis and products prevalence numerous natural products, pharmaceuticals functional materials, the alkene difunctionalization methods for selective transformations of olefins are important have attracted much attention form synthetic chemists. Among them, electrochemical reaction is particularly promising has becoming a potent sustainable tool alkenes into vicinal difunctionalized structures organic through simultaneous incorporation two groups. Herein, we summarize recent progress reactions according types as well category radicals over past five years. By selecting remarkable examples, elaborately discussed substrate scope mechanisms olefin reaction.
Язык: Английский
Процитировано
1
Chemical Society Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
This review highlights organo-mediators that enable electrochemical reactions via outer-sphere electron transfer (ET), offering advantages such as availability, tunability, and simplified post-processing compared to direct electrolysis.
Язык: Английский
Процитировано
1
Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(22), С. 5735 - 5745
Опубликована: Янв. 1, 2023
During the past decade, photo- and electrochemical reactions proceeding via single-electron-transfer (SET) triggered radical pathways have emerged as an indispensable strategy for efficient formation of chemical bonds.
Язык: Английский
Процитировано
20
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Дек. 13, 2023
An electroreductive strategy for radical hydroxyl fluorosulfonylation of alkenes with sulfuryl chlorofluoride and molecular oxygen from air is described. This mild protocol displays excellent functional group compatibility, broad scope, good scalability, providing convenient access to diverse β-hydroxy sulfonyl fluorides. These fluoride products can be further converted valuable aliphatic fluorides, β-keto β-alkenyl Further, some these showed inhibitory activity against Botrytis cinerea or Bursaphelenchus xylophilus, which could useful potent agrochemical discovery. Preliminary mechanistic studies indicate that this transformation achieved through rapid O2 interception by the alkyl subsequent reduction peroxy radical, outcompete other side reactions such as chlorine atom transfer, hydrogen Russell fragmentation.
Язык: Английский
Процитировано
18
Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(15), С. 4318 - 4342
Опубликована: Янв. 1, 2024
This review primarily focuses on the generation of aryl radicals via an electroreduction strategy, and systematically elaborates synthetic applications, scope, limitations substrates.
Язык: Английский
Процитировано
9
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(15), С. 10660 - 10677
Опубликована: Июль 18, 2024
Two general protocols for the regioselective electrochemically enabled sulfonylation cyclization of
Язык: Английский
Процитировано
8
Hybrid Advances, Год журнала: 2024, Номер 6, С. 100268 - 100268
Опубликована: Авг. 1, 2024
Control of redox processes at the molecular level is central to synthesis, and electrochemistry provides a unique means directing electron flow for chemical transformations. Although chemistry community has long recognized its power, potential electrochemical methods in organic synthesis not been nearly as exploited academically or industrially. In this respect, review related applying nano-photocatalysts fine producing compounds presented. The existing laboratory industrial are too resource-intensive, mostly based on non-renewable energy sources, often require extreme conditions regarding temperature pressure. review, we emphasize forward transformations realizable with help such nanomaterials under UV/visible light exposure. Nanophotocatalysts thus offer huge green high-value-added organics. This outlines organics nanophotocatalysts, graphene semiconductors, titanium oxide, quantum dots, carbon-based catalysts. aims present current research field provide an impetus helpers further build area social impact. For first time, all-inclusive approach helps bridge gaps between these different areas view challenges electro-organic photocatalysis.
Язык: Английский
Процитировано
7
Angewandte Chemie International Edition, Год журнала: 2023, Номер 63(7)
Опубликована: Дек. 21, 2023
Abstract Catalytic hydrogenation of nitriles represents an efficient and sustainable one‐step synthesis valuable bulk fine chemicals. We report herein a molecular cobalt electrocatalyst for selective hydrogenative coupling with amines using protons as the hydrogen source. The key to success this reductive reaction is use electrocatalytic approach cobalt‐hydride generation through sequence cathodic reduction protonation. As only electrons (e − ) (H + redox equivalent source, general electrohydrogenation protocol showcased by highly straightforward various functionalized structurally diverse amines, well deuterium isotope labeling applications. Mechanistic studies reveal that electrogenerated transfer nitrile process rate‐determining step.
Язык: Английский
Процитировано
15