ACS Catalysis,
Год журнала:
2024,
Номер
14(13), С. 9708 - 9733
Опубликована: Июнь 13, 2024
Recent
global
events
have
led
to
the
cost
of
platinum
group
metals
(PGMs)
reaching
unprecedented
heights.
Many
chemical
companies
are
therefore
starting
seriously
consider
and
evaluate
if
where
they
can
substitute
PGMs
for
non-PGMs
in
their
catalytic
processes.
This
review
covers
recent
highly
relevant
applications
non-PGM
catalysts
modern
pharmaceutical
industry.
By
highlighting
these
selected
successful
examples
non-PGM-catalyzed
processes
from
literature,
we
hope
emphasize
enormous
potential
catalysis
inspire
further
development
within
this
field
enable
technology
progress
toward
manufacturing
We
also
present
some
historical
contexts
perceived
advantages
challenges
implementing
environment.
Organic Process Research & Development,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
A
scalable
electrochemical
process
to
synthesize
iminophosphorane
ligands
is
reported.
The
application
of
these
iminophosphoranes
was
recently
reported
in
Ni-catalyzed
cross-electrophile
and
C–N
cross-couplings.
use
parallel
plate
flow
reactors
enables
the
synthesis
on
a
multigram
scale,
with
selected
examples
up
0.6
kg
scale.
Direct
crystallization
from
end
reaction
mixture
for
provides
facile
isolation
processes.
This
article
also
details
improvements
our
capabilities
across
scales,
including
addressing
material
compatibility
issues,
increasing
accessible
range
rates,
integration
analytical
technology
tools.
National Science Review,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Electrooxidation
strategies
for
synthesizing
readily
oxidizable
products
face
notable
challenges,
especially
when
the
oxidation
potential
of
is
lower
than
that
reactants
or
high
current
densities
are
necessary.
The
electrooxidation
synthesis
trivalent
organophosphorus
compounds
(OPCs
(III))
from
white
phosphorus
(P4)
has
demonstrated
but
hindered
by
selectivity
issues
due
to
over-oxidation.
Herein,
we
report
a
tandem
electro-thermal
pathway
addresses
these
challenges
in
producing
OPCs
(III)
P4.
process
begins
with
an
step
generates
stable
transfer
reagent,
then
thermochemically
converted
into
various
high-value
(III).
Utilizing
hexafluoroisopropanol
(HFIP)
as
nucleophile
and
optimizing
tetrabutylammonium
iodide
(TBAI)-4-dimethylaminopyridine
(DMAP)-adduct
catalytic
system,
developed
efficient
electrophilic
reagent
via
electrosynthesis.
adduct
facilitates
P4
enhances
nucleophilicity
HFIP,
thereby
improving
process.
This
approach
supports
density,
scales
up
hundred-gram
level
without
yield
loss,
remains
compatible
fluctuating
green
electricity.
The Journal of Physical Chemistry C,
Год журнала:
2025,
Номер
129(6), С. 3014 - 3021
Опубликована: Фев. 3, 2025
The
formation
of
substituted
benzyl
alcohols
from
dicyanobenzenes
and
methanol
(C–C
coupling)
is
demonstrated
as
a
model
system
for
paired
electrosynthesis
investigated
at
interdigitated
microband
array
electrodes
in
microreactor
with/without
intentionally
added
supporting
electrolyte.
A
Pt–Pt
with
5
μm
bands
separated
by
gaps
employed
dimethyl
sulfoxide
(DMSO)
solvent.
Yields
are
optimized
to
approximately
50%
the
point
100%
conversion.
mechanism
employing
isotope
labeling
(CD3OD,
CH3OD,
d6-DMSO,
13CH3OH).
methylene
group
(12C
or
13C)
obtained
H2,
D2,
DH
substitution
patterns,
hypothesis
corresponding
discussed
aided
density
functional
theory
(DFT)
calculations.
Implications
sustainable
discussed.
Chemical Society Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
highlights
organo-mediators
that
enable
electrochemical
reactions
via
outer-sphere
electron
transfer
(ET),
offering
advantages
such
as
availability,
tunability,
and
simplified
post-processing
compared
to
direct
electrolysis.
Chemical Society Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Utilizing
electrons
directly
offers
significant
potential
for
advancing
organic
synthesis
by
facilitating
novel
reactivity
and
enhancing
selectivity
under
mild
conditions.
As
a
result,
an
increasing
number
of
chemists
are
exploring
electrosynthesis.
However,
the
efficacy
electrochemical
transformations
depends
critically
on
design
cell.
Batch
cells
often
suffer
from
limitations
such
as
large
inter-electrode
distances
poor
mass
transfer,
making
flow
promising
alternative.
Implementing
cells,
however,
requires
foundational
understanding
microreactor
technology.
In
this
review,
we
briefly
outline
applications
electrosynthesis
before
providing
comprehensive
examination
existing
reactor
technologies.
Our
goal
is
to
equip
with
insights
needed
tailor
their
meet
specific
requirements
effectively.
We
also
highlight
application
designs
in
scaling
up
processes
integrating
high-throughput
experimentation
automation.
These
advancements
not
only
enhance
synthetic
community
but
hold
promise
both
academia
industry.
Chemical Science,
Год журнала:
2024,
Номер
15(16), С. 5980 - 5992
Опубликована: Янв. 1, 2024
N
-Cyano
iminophosphoranes
are
synthesized
using
electrochemistry
and
evaluated
as
ligands
in
various
nickel-catalysed
reactions.
The
electronic
structural
properties
of
these
were
studied
both
computationally
experimentally.
