Recent advances in nanomaterials for integrated phototherapy and immunotherapy

Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216608 - 216608

Опубликована: Март 27, 2025

Язык: Английский

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Yeast β-glucan-based nanoparticles loading methotrexate promotes osteogenesis of hDPSCs and periodontal bone regeneration under the inflammatory microenvironment

Carbohydrate Polymers, Год журнала: 2024, Номер 342, С. 122401 - 122401

Опубликована: Июнь 13, 2024

Язык: Английский

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Effect of Surface-engineered AuNPs on gene expression, bacterial interaction, protein denaturation, and toxicology assay: An in vitro and in vivo model

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

We investigated the in vitro and vivo uses of pamoic acid functionalized gold nanoparticles (PA@AuNPs), with a focus on determining their safety potential toxicity living beings. To test this theory, bacterial interaction PA@AuNPs was studied using Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa cultures, as well inhibition bovine serum albumin (BSA) protein. The real-time polymerase chain reaction (RT-PCR) is used to measure expression target genes. caused dose-dependent cell death MDA-MB-231, triple-negative breast cancer (BC) line, an LC50 -42.23 μL mL-1. It also apoptosis BC cells. results indicated that early weeks, inflammatory cells (mostly neutrophils macrophages) penetrated connective tissue, but latter substantial number fibroblasts fibrocytes were identified. Changes vascular channels, extravasated red blood (RBCs), necrosis are all indicators growing tissue pathology. These data could point dynamic process including anti-inflammatory response followed by remodeling or repair. findings show not hazardous tested Sprague Dawley rats, highly biocompatible, can be variety biological applications.

Язык: Английский

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Nanoparticles, a promising treatment for gastric cancer

Smart Materials in Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Expert consensus on orthodontic treatment of patients with periodontal disease

International Journal of Oral Science, Год журнала: 2025, Номер 17(1)

Опубликована: Апрель 3, 2025

Patients with periodontal disease often require combined periodontal-orthodontic interventions to restore health, function, and aesthetics, ensuring both patient satisfaction long-term stability. Managing these patients involving orthodontic tooth movement can be particularly challenging due compromised soft hard tissues, especially in severe cases. Therefore, close collaboration between orthodontists periodontists for comprehensive diagnosis sequential treatment, along diligent compliance throughout the entire process, is crucial achieving favorable treatment outcomes. Moreover, retention follow-up are essential sustain success. This expert consensus, informed by latest clinical research practical experience, addresses considerations of patients, delineating indications, objectives, procedures, principles aim providing clear guidance practitioners.

Язык: Английский

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Recent advances in nano-enhanced biosensors: Innovations in design, applications in healthcare, environmental monitoring, and food safety, and emerging research challenges

Sensing and Bio-Sensing Research, Год журнала: 2025, Номер unknown, С. 100783 - 100783

Опубликована: Апрель 1, 2025

Язык: Английский

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Recent advances in polydopamine-coated metal–organic frameworks for cancer therapy

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Апрель 1, 2025

The creation and development of classical multifunctional nanomaterials are crucial for the advancement nanotherapeutic treatments tumors. Currently, metal–organic frameworks (MOFs) modified with polydopamine (PDA) at forefront nanomedicine research, particularly in tumor diagnostics therapy, owing to their exceptional biocompatibility, expansive specific surface area, multifaceted functionalities, superior photothermal properties, which led significant advancements anti-tumor research. Consequently, a range anti-cancer strategies has been devised by leveraging capabilities MOFs, including intelligent drug delivery systems, photodynamic tailored microenvironment. In order gain deeper insight into role MOFs@PDA cancer diagnosis treatment, it is essential conduct comprehensive review existing research outcomes promptly analyze challenges associated biological applications. This will provide valuable perspectives on potential clinical settings.

Язык: Английский

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From Detection to Treatment: Nanomaterial-Based Biosensors Transforming Prosthetic Dentistry and Oral Health Care: A Scoping Review

Prosthesis, Год журнала: 2025, Номер 7(3), С. 51 - 51

Опубликована: Май 14, 2025

Background: Nanomaterial-based biosensors represent a transformative advancement in oral health diagnostics and therapeutics, offering superior sensitivity selectivity for early disease detection compared to conventional methods. Their applications span prosthetic dentistry, where they enable the precise monitoring of dental implants, theranostics conditions such as caries, cancers, periodontal diseases. These innovations promise enhance proactive healthcare by integrating detection, treatment, preventive strategies. Objectives: This review comprehensively examines role nanomaterial-based theranostics, with focus on applications. It emphasizes their utility implant surveillance, identification prosthesis-related complications, broader implications personalized treatment paradigms. Methods: A systematic literature search was conducted across PubMed, Scopus, Web Science studies published between 2010 2025. Keywords included combinations “nanomaterials”, “biosensors”, “dentistry”, “oral health”, “diagnostics”, “therapeutics”, “theranostics”. Articles were selected based relevance nanomaterial clinical translation. Results: The identified diverse classes nanomaterials—such metallic nanoparticles, carbon-based structures, quantum dots—whose unique physicochemical properties biosensor performance. Key advancements include ultra-sensitive biomarkers saliva gingival crevicular fluid, real-time peri-implant inflammatory markers, cost-effective diagnostic platforms. systems demonstrate exceptional precision detecting early-stage pathologies while improving operational efficiency settings. Conclusions: hold significant revolutionizing care through complication detection. Despite challenges related biocompatibility, scalable manufacturing, rigorous validation, these technologies may redefine extending device longevity, enabling interventions, reducing long-term costs. Future research must address translational barriers fully harness potential accuracy therapeutic outcomes.

Язык: Английский

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AuNP@DNA nanoflares: Preparation and application in bioanalysis and biomedicine

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110524 - 110524

Опубликована: Окт. 1, 2024

Язык: Английский

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Uncovering Molecular and Genetic Drivers of Dental Caries Via scRNA-seq and Mendelian Randomisation

International Dental Journal, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Dental caries remains a prevalent oral health problem globally, influenced by environmental, genetic, and microbial factors. Traditional studies have emphasised colonisation dietary sugars, neglecting the intricate molecular genetic interactions. This study aimed to integrate single-cell RNA sequencing (scRNA-seq) with Mendelian randomisation (MR) elucidate factors contributing susceptibility progression of dental caries.

Язык: Английский

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