Effect of Surface-engineered AuNPs on gene expression, bacterial interaction, protein denaturation, and toxicology assay: An in vitro and in vivo model

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

We investigated the in vitro and vivo uses of pamoic acid functionalized gold nanoparticles (PA@AuNPs), with a focus on determining their safety potential toxicity living beings. To test this theory, bacterial interaction PA@AuNPs was studied using Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa cultures, as well inhibition bovine serum albumin (BSA) protein. The real-time polymerase chain reaction (RT-PCR) is used to measure expression target genes. caused dose-dependent cell death MDA-MB-231, triple-negative breast cancer (BC) line, an LC50 -42.23 μL mL-1. It also apoptosis BC cells. results indicated that early weeks, inflammatory cells (mostly neutrophils macrophages) penetrated connective tissue, but latter substantial number fibroblasts fibrocytes were identified. Changes vascular channels, extravasated red blood (RBCs), necrosis are all indicators growing tissue pathology. These data could point dynamic process including anti-inflammatory response followed by remodeling or repair. findings show not hazardous tested Sprague Dawley rats, highly biocompatible, can be variety biological applications.

Language: Английский

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Recent advances in polydopamine-coated metal–organic frameworks for cancer therapy

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 1, 2025

The creation and development of classical multifunctional nanomaterials are crucial for the advancement nanotherapeutic treatments tumors. Currently, metal–organic frameworks (MOFs) modified with polydopamine (PDA) at forefront nanomedicine research, particularly in tumor diagnostics therapy, owing to their exceptional biocompatibility, expansive specific surface area, multifaceted functionalities, superior photothermal properties, which led significant advancements anti-tumor research. Consequently, a range anti-cancer strategies has been devised by leveraging capabilities MOFs, including intelligent drug delivery systems, photodynamic tailored microenvironment. In order gain deeper insight into role MOFs@PDA cancer diagnosis treatment, it is essential conduct comprehensive review existing research outcomes promptly analyze challenges associated biological applications. This will provide valuable perspectives on potential clinical settings.

Language: Английский

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Nanoparticles, a promising treatment for gastric cancer

Smart Materials in Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Recent advances in nanomaterials for integrated phototherapy and immunotherapy

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216608 - 216608

Published: March 27, 2025

Language: Английский

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Expert consensus on orthodontic treatment of patients with periodontal disease

International Journal of Oral Science, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 3, 2025

Patients with periodontal disease often require combined periodontal-orthodontic interventions to restore health, function, and aesthetics, ensuring both patient satisfaction long-term stability. Managing these patients involving orthodontic tooth movement can be particularly challenging due compromised soft hard tissues, especially in severe cases. Therefore, close collaboration between orthodontists periodontists for comprehensive diagnosis sequential treatment, along diligent compliance throughout the entire process, is crucial achieving favorable treatment outcomes. Moreover, retention follow-up are essential sustain success. This expert consensus, informed by latest clinical research practical experience, addresses considerations of patients, delineating indications, objectives, procedures, principles aim providing clear guidance practitioners.

Language: Английский

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Recent advances in nano-enhanced biosensors: Innovations in design, applications in healthcare, environmental monitoring, and food safety, and emerging research challenges

Sensing and Bio-Sensing Research, Journal Year: 2025, Volume and Issue: unknown, P. 100783 - 100783

Published: April 1, 2025

Language: Английский

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Yeast β-glucan-based nanoparticles loading methotrexate promotes osteogenesis of hDPSCs and periodontal bone regeneration under the inflammatory microenvironment

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 342, P. 122401 - 122401

Published: June 13, 2024

Language: Английский

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AuNP@DNA nanoflares: Preparation and application in bioanalysis and biomedicine

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110524 - 110524

Published: Oct. 1, 2024

Language: Английский

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Uncovering Molecular and Genetic Drivers of Dental Caries Via scRNA-seq and Mendelian Randomisation

International Dental Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Dental caries remains a prevalent oral health problem globally, influenced by environmental, genetic, and microbial factors. Traditional studies have emphasised colonisation dietary sugars, neglecting the intricate molecular genetic interactions. This study aimed to integrate single-cell RNA sequencing (scRNA-seq) with Mendelian randomisation (MR) elucidate factors contributing susceptibility progression of dental caries.

Language: Английский

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A narrative review on applications of nanotechnology in modern endodontics

Deleted Journal, Journal Year: 2024, Volume and Issue: 15(1), P. 1 - 8

Published: Dec. 24, 2024

Abstract Nanotechnology in modern endodontics involves manipulating materials at the nanoscale to improve dental treatments, disinfection, imaging, and tissue engineering. This narrative review aims evaluate impact applications of nanotechnology endodontics, focusing on advancements materials, disinfection processes, imaging techniques, engineering while addressing associated challenges safety concerns. A comprehensive literature search was conducted March 2024 across PubMed, SCOPUS, EMBASE, COCHRANE Library, Science Direct databases using MeSH terms/keywords such as “Nanotechnology,” “Endodontics,” “Disinfection,” “Dental Tissue Engineering.” Articles published from 2010 were considered, with inclusion criteria studies relevant objectives. From an initial pool 774 articles, 86 selected based titles abstracts, 45 shortlisted after full-text evaluation. The highlights significant endodontic methods, Nanomaterials have improved efficiency, precision, biocompatibility treatments. However, long-term biocompatibility, standardization applications, patient remain be addressed. Continuous research, ethical practices, regulatory oversight are crucial for integrating into endodontics. While offers promising ongoing research collaboration among researchers, clinicians, bodies essential harness its full potential ensure safety. Limitations this include biases article selection evolving nature research.

Language: Английский

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