Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Over
the
past
two
decades,
iron-based
metal-organic
frameworks
(Fe-MOFs)
have
attracted
significant
research
interest
in
biomedicine
due
to
their
low
toxicity,
tunable
degradability,
substantial
drug
loading
capacity,
versatile
structures,
and
multimodal
functionalities.
Despite
great
potential,
transition
of
Fe-MOFs-based
composites
from
laboratory
clinical
products
remains
challenging.
This
review
evaluates
key
properties
that
distinguish
Fe-MOFs
other
MOFs
highlights
recent
advances
synthesis
routes,
surface
engineering,
shaping
technologies.
In
particular,
it
focuses
on
applications
biosensing,
antimicrobial,
anticancer
therapies.
addition,
emphasizes
need
develop
scalable,
environmentally
friendly,
cost-effective
production
methods
for
additional
meet
specific
requirements
various
biomedical
applications.
ability
combine
therapies,
hurdles
still
remain,
including
a
deeper
understanding
therapeutic
mechanisms
potential
risks
resistance
overdose.
Systematically
addressing
these
challenges
could
significantly
enhance
prospects
potentially
facilitate
integration
into
mainstream
practice.
Abstract
Metal–organic
frameworks
(MOFs)
are
highly
studied
for
solar
H
2
production
from
O
due
to
their
abundant
active
sites
and
open
pore
channels.
Titanium
(Ti)
Zirconium
(Zr)
MOFs
particularly
noted
stability
optoelectronic
properties,
resembling
conventional
metal
oxide
semiconductors.
These
allow
molecular‐level
tuning
alter
creating
opportunities
enhance
catalytic
activity.
Introducing
defects
in
the
MOF's
structure
is
a
versatile
strategy
modifying
molecular
topology,
morphology,
optical
electronic
properties.
This
review
compiles
essential
methods
synthesizing
defect‐oriented
MOFs,
discussing
characterization
techniques
structural
modifications
boost
It
also
highlights
connection
between
photocatalytic
MOF
exploring
strategies
address
current
limitations
using
defective
Ti
Zr‐based
MOFs.
Additionally,
role
of
machine
learning
(ML)
predicting
properties
faster
material
discovery
optimization
emphasized.
aims
identify
challenges
propose
ideas
designing
future
photocatalysts.
Accounts of Chemical Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 28, 2024
ConspectusEnzymes
are
highly
efficient
and
selective
catalysts
that
operate
under
mild
conditions,
making
them
invaluable
for
various
chemical
transformations.
However,
their
limitations,
such
as
instability
high
cost,
call
advancements
in
enzyme
immobilization
the
development
of
suitable
host
materials.
Metal-organic
frameworks
(MOFs),
characterized
by
porosity,
crystallinity,
tunability,
promising
candidates
encapsulation.
Among
these,
zirconium-based
MOFs
(Zr-MOFs)
stand
out
due
to
exceptional
structural
diversity
stability.
The
physical
properties
Zr-MOFs
can
be
tuned
with
atomic
precision,
interactions
enzymes
analyzed
through
a
range
techniques
spanning
from
chemistry
materials
science
biochemistry.
This
tunable
platform
provides
opportunities
systematically
investigate
impact
encapsulation
on
stability
activity
order
develop
design
rules
hosts.In
this
Account,
we
discuss
experimentally
validated
concepts
designing
MOF
hosts
based
mechanisms.
We
present
methods
enhance
catalytic
performance
strategies
creating
multifunctional
enzyme@MOF
systems
via
modifications.
start
highlighting
importance
maximizes
substrate
diffusion
availability,
particular
focus
containing
hierarchical
mesoporous
structures
those
Inorganic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Owing
to
the
rapid
development
of
nuclear
industry,
uranium
has
become
a
global
environmental
contaminant
due
its
radiotoxicity
and
chemotoxicity,
posing
significant
threats
human
health
ecological
safety.
Although
various
instrumental
chemical
analytical
methods
have
been
developed
for
uranyl
ion
detection
in
aquatic
environments,
searching
new
sensors
with
high
stability,
sensitivity,
selectivity
remains
challenge.
In
this
study,
luminescent
Zr-based
metal–organic
framework
(MOF),
designated
as
Tb@UiO-66-(COOH)2,
was
successfully
synthesized
utilizing
postsynthetic
exchange
(PSE)
method
along
Tb3+
doping
detection.
Interestingly,
presence
UO22+
ions
causes
replacement
guest
(Tb3+)
sensor
via
competitive
host–guest
interaction,
leading
luminescence
quenching.
The
attenuation
intensity
Tb@UiO-66-(COOH)2
exhibits
an
excellent
linear
relationship
concentrations
within
wide
range
0–2.52
μM.
Notably,
demonstrates
unprecedentedly
sensitivity
(Ksv
=
2.16
×
105
M–1)
extremely
low
limit
(LOD)
down
8.03
nM
(1.91
ppb)
deionized
water.
More
importantly,
can
achieve
efficient
performance,
even
excesses
competing
ions.
values
Ksv
were
determined
be
2.10
M–1
Xie'ao
Lake
water
3.05
seawater;
LOD
8.26
(1.96
5.68
(1.35
seawater.
To
best
our
knowledge,
is
first
instance
introducing
coordination
strategy
into
MOF-based
high-performance
Hence,
present
work
offers
novel
idea
building
functional
MOFs
aqueous
solutions.
