Natural Product-Inspired Vanadium Pentoxide Nanoparticles Unlock Diabetic Therapeutic Potential: In Vitro and In Silico Evaluation

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Mimicking the action of insulin and inhibition specific enzymes involved in glucose metabolism by vanadium pentoxide (V2O5) make it a candidate for diabetes control, but its low absorption, unpredictable change oxidation state body passage, inadequate ability to bond with intended site limit activity. Here, okra extract-capped V2O5 nanoparticles (ONPs) are fabricated, which exhibit significant absorptivity, mucoadhesion, control release producing vanadate ions as an intermediate. Further, they have been exploited antioxidant, anti-inflammatory, antidiabetic studies. Characterization results demonstrated presence extract over surface nanoparticles. A capped nanodrug exhibited enhanced electroactive rough area groove-shaped pores. Fabricated ONPs were their properties. Results achieved from vitro studies molecular docking indicate properties 80.00 ± 1.73% 69.93 1.86% efficiency against α-amylase α-glucosidase, respectively, without affecting growth probiotic Bifidobacterium adolescentis bifidum present human gut. The cytotoxicity on HacaT cell line uptake assay HepG2 promising drug.

Язык: Английский

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The Impact of Okra on metabolic parameters in Type 2 Diabetes Patients: Results from a Double-Blind Clinical Trial

Advances in Integrative Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Puerarin Targets HIF-1α to Modulate Hypoxia-Related Sphingolipid Metabolism in Diabetic Hepatopathy via the SPTLC2/Ceramide Pathway

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 398 - 398

Опубликована: Март 12, 2025

Background and Objectives: Diabetic hepatopathy, characterized by hepatic hypoxia metabolic dysregulation, has a rising global incidence prevalence, with limited effective treatments. Hepatic activates hypoxia-inducible factor-1 alpha (HIF-1α), regulating sphingolipid metabolism elevating ceramide, key factor in insulin resistance. Puerarin (Pue), flavonoid derived from Pueraria lobata, exhibits therapeutic effects diabetes, but its on hypoxia-related are unclear. This study investigates Pue’s mechanisms modulating metabolism, focusing HIF-1α metabolism. Methods: Using bioinformatics molecular docking, was identified as target diabetic liver disease, confirmed via drug affinity responsive stability. In vitro experiments utilized insulin-resistant HepG2 cells to assess glucose intake expression. vivo, type 2 diabetes mellitus (T2DM) induced mice using high-fat diet streptozotocin injections. Pue administration evaluated for fasting blood glucose, oral tolerance, hepatoprotective effects. Liver metabolomics qPCR/Western blot analyses were conducted pathways. Results: increased uptake bound HIF-1α. reduced expression cells, an effect attenuated the stabilizer DMOG. improved T2DM mice, which DMOG reversed. Metabolomics revealed that modulates decreasing ceramide content. qPCR Western results dramatically decreases SPTLC2 Conclusions: improves hepatopathy reducing through HIF-1α/SPTLC2 pathway, offering novel strategy management.

Язык: Английский

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The role of plant-based dietary compounds in gut microbiota modulation in inflammatory bowel disease

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Май 30, 2025

IBD, which includes Crohn’s and ulcerative colitis, is associated with gut microbiota dysbiosis. The dysbiotic environment results in an elevation of harmful a diminution advantageous microbiota, leading to IBD. Interestingly, plant-based dietary compounds consisting fibers polyphenols have demonstrated promise be safe successful IBD treatment, studies revealing that they can improve dysbiosis, increase anti-inflammatory cytokines, decrease pro-inflammatory lower oxidative stress, barrier function. Plant-based shown potential reduce by regulating signaling pathways such as TGF-β/Smad, TRL-4/NF-κB/MAPK, TLR2-NF-κB, autophagy, pyroptosis, glycolysis/gluconeogenesis amino acid metabolism, Nrf-2/HO-1, microbiota-macrophage-arginine bile metabolism. Additionally, assist forming short-chain fatty acids other metabolites, help regulate immune cells alleviate Recent research indicates compounds, either nanoparticles or encapsulated nanoparticles, effectively treating Despite the beneficial role detrimental effects cancer promotion exacerbation responses. Therefore, this will clinicians/individuals plan their nutrition prevent exacerbation. This review highlights signatures linked examines impact dysbiosis on It also provides comprehensive discussion how influence modulation hold for

Язык: Английский

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Atractylodes macrocephala Rhizoma alleviates blood hyperviscosity induced by high-fat, high-sugar, and high-salt diet via inhibition of gut-liver inflammatory activation and fibrinogen synthesis

Journal of Ethnopharmacology, Год журнала: 2024, Номер 338, С. 119034 - 119034

Опубликована: Ноя. 4, 2024

Язык: Английский

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