Natural Product-Inspired Vanadium Pentoxide Nanoparticles Unlock Diabetic Therapeutic Potential: In Vitro and In Silico Evaluation

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Mimicking the action of insulin and inhibition specific enzymes involved in glucose metabolism by vanadium pentoxide (V2O5) make it a candidate for diabetes control, but its low absorption, unpredictable change oxidation state body passage, inadequate ability to bond with intended site limit activity. Here, okra extract-capped V2O5 nanoparticles (ONPs) are fabricated, which exhibit significant absorptivity, mucoadhesion, control release producing vanadate ions as an intermediate. Further, they have been exploited antioxidant, anti-inflammatory, antidiabetic studies. Characterization results demonstrated presence extract over surface nanoparticles. A capped nanodrug exhibited enhanced electroactive rough area groove-shaped pores. Fabricated ONPs were their properties. Results achieved from vitro studies molecular docking indicate properties 80.00 ± 1.73% 69.93 1.86% efficiency against α-amylase α-glucosidase, respectively, without affecting growth probiotic Bifidobacterium adolescentis bifidum present human gut. The cytotoxicity on HacaT cell line uptake assay HepG2 promising drug.

Language: Английский

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The Impact of Okra on metabolic parameters in Type 2 Diabetes Patients: Results from a Double-Blind Clinical Trial

Advances in Integrative Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Puerarin Targets HIF-1α to Modulate Hypoxia-Related Sphingolipid Metabolism in Diabetic Hepatopathy via the SPTLC2/Ceramide Pathway

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 398 - 398

Published: March 12, 2025

Background and Objectives: Diabetic hepatopathy, characterized by hepatic hypoxia metabolic dysregulation, has a rising global incidence prevalence, with limited effective treatments. Hepatic activates hypoxia-inducible factor-1 alpha (HIF-1α), regulating sphingolipid metabolism elevating ceramide, key factor in insulin resistance. Puerarin (Pue), flavonoid derived from Pueraria lobata, exhibits therapeutic effects diabetes, but its on hypoxia-related are unclear. This study investigates Pue’s mechanisms modulating metabolism, focusing HIF-1α metabolism. Methods: Using bioinformatics molecular docking, was identified as target diabetic liver disease, confirmed via drug affinity responsive stability. In vitro experiments utilized insulin-resistant HepG2 cells to assess glucose intake expression. vivo, type 2 diabetes mellitus (T2DM) induced mice using high-fat diet streptozotocin injections. Pue administration evaluated for fasting blood glucose, oral tolerance, hepatoprotective effects. Liver metabolomics qPCR/Western blot analyses were conducted pathways. Results: increased uptake bound HIF-1α. reduced expression cells, an effect attenuated the stabilizer DMOG. improved T2DM mice, which DMOG reversed. Metabolomics revealed that modulates decreasing ceramide content. qPCR Western results dramatically decreases SPTLC2 Conclusions: improves hepatopathy reducing through HIF-1α/SPTLC2 pathway, offering novel strategy management.

Language: Английский

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Atractylodes macrocephala Rhizoma alleviates blood hyperviscosity induced by high-fat, high-sugar, and high-salt diet via inhibition of gut-liver inflammatory activation and fibrinogen synthesis

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 338, P. 119034 - 119034

Published: Nov. 4, 2024

Language: Английский

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