Intramolecular/Intermolecular Sequential Cyclization Accompanied by Double C–F Bond Cleavage: Access to Tricyclic Fluorine-Containing Pyrano[3,2-c]chromenes DOI
Dongsheng Yang, Xiang‐Long Chen, Chun‐Yan Wu

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(22), С. 16553 - 16563

Опубликована: Окт. 28, 2024

Defluorinative cyclization of CF

Язык: Английский

“On-water” defluorinative cyclization of trifluoromethyl enones with phosphine oxides: synthesis of polysubstituted furans DOI

Man-Hang Feng,

Shu-Ji Gao,

M Kellis

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(14), С. 3974 - 3981

Опубликована: Янв. 1, 2024

A defluorinative cyclization of readily available trifluoromethyl enones with phosphine oxides for the synthesis polysubstituted furans is developed in a pure water solution.

Язык: Английский

Процитировано

10

Water-promoted defluorinative synthesis of fluoroalkylated 1,5-diazapentadienes by using (NH4)2CO3 as an NH2 and NH source DOI
Wei Han, Yulan Chen,

Xi Tang

и другие.

Green Chemistry, Год журнала: 2023, Номер 25(23), С. 9672 - 9679

Опубликована: Янв. 1, 2023

A H 2 O-promoted and (NH 4 ) CO 3 -enabled defluoroiminization reaction of fluoroalkyl alkenes for the synthesis fluoroalkylated 1,5-diazapentadienes has been developed.

Язык: Английский

Процитировано

17

Sequential In Situ-Formed Kukhtin–Ramirez Adduct and P(NMe2)3-Catalyzed O-Phosphination of α-Dicarbonyls with P(O)–H DOI
Yuan‐Yuan Huang, Nan Wang, Zheng‐Guang Wu

и другие.

Organic Letters, Год журнала: 2023, Номер 25(42), С. 7595 - 7600

Опубликована: Окт. 13, 2023

O-Phosphination of α-dicarbonyls via sequential in situ formation a Kukhtin-Ramirez adduct and P(NMe2)3-catalyzed process has been exploited for the synthesis α-phosphoryloxy carbonyls. A range P(O)-H derivatives, including diarylphosphine oxides, arylphosphinates, phosphinates, are competent candidates to be introduced into this transformation, various carbonyls obtained. This approach possesses advantages mild conditions, simple operations, atom economy, high efficiency, gram-scale synthesis, which make it promising toolbox.

Язык: Английский

Процитировано

10

TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium DOI

Qiang Huang,

Xin Jin,

Lvjia Wu

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(19), С. 3860 - 3865

Опубликована: Янв. 1, 2024

The aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient mild approach to access various α-aminoalkylphosphine in good yields tolerance functional groups using H 2 O as a clean solvent.

Язык: Английский

Процитировано

4

Combining Hydrodefluorination and Defluorophosphorylation for Chemo- and Stereoselective Synthesis of gem-Fluorophosphine Alkenes DOI

Ya‐Fei Hu,

Man-Hang Feng,

Peng‐Yuan Zhang

и другие.

Organic Letters, Год журнала: 2023, Номер 25(34), С. 6368 - 6373

Опубликована: Авг. 18, 2023

A chemo-, regio-, and stereoselective reaction of trifluoromethyl enones, phenylsilane, phosphine oxides through a sequential hydrodefluorination defluorophosphorylation relay is developed for the synthesis distinctive gem-fluorophosphine alkenes. This multicomponent occurred under transition-metal-free conditions with good functional group tolerance. Moreover, preinstalled carbonyl auxiliary important tuning reactivity β-trifluoromethyl thereby enabling controllable selective functionalization two fluorine atoms in trifluoromethylated enones.

Язык: Английский

Процитировано

9

Sulfonylation of 2-Haloquinolines with Sulfonyl Hydrazides in Water for Accessing 2-Sulfonyl Quinolines under Catalyst-, Reductant-, and Additive-Free Conditions DOI

Bo‐Jie Huo,

Yuan-Shuai Wu,

Chengping Miao

и другие.

Tetrahedron, Год журнала: 2025, Номер unknown, С. 134705 - 134705

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Transition‐Metal‐Free Carbonyl Reduction and Hydrodefluorination of β‐Trifluoromethyl Enones with Hydrosilanes: Synthesis of gem‐Difluorovinyl Alcohols DOI

Peng‐Yuan Zhang,

Ya‐Fei Hu,

Jia‐Hao Chu

и другие.

European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(23)

Опубликована: Апрель 20, 2024

Abstract A tandem carbonyl reduction and hydrodefluorination of β‐trifluoromethyl enones with hydrosilanes under transition‐metal‐free conditions was developed for the synthesis a variety valuable gem ‐difluorovinyl alcohols. The hydrosilane could act as both reductive agent C(sp 3 )‐F bond‐breaking promoter mild reaction conditions. Synthetically useful organofluorides, such ‐fluorophosphine alkene, ketone, fluorinated dihydrofuran derivatives be readily constructed by further transformations obtained Moreover, method features conditions, operational simplicity, excellent functional group tolerance, scalability.

Язык: Английский

Процитировано

2

Nickel-Catalyzed Hydrodefluorination/Deuterodefluorination of CF3-alkenes with Formic Acid DOI
Peng Yang, Haiping Yu,

Runze Zhai

и другие.

Chemical Communications, Год журнала: 2024, Номер 60(51), С. 6548 - 6551

Опубликована: Янв. 1, 2024

The synthesis of deuterated

Язык: Английский

Процитировано

2

“On‐Water” Synthesis of Sterically Congested γ‐Ketophosphine Oxides Featuring a CF3‐ and P(O)‐Tetrasubstituted Carbon Center DOI

Man‐Hang Feng,

Wenjun Ji,

Bo‐Jie Huo

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2023, Номер 365(20), С. 3546 - 3552

Опубликована: Сен. 16, 2023

Abstract The distinctive hydrophobic hydration effect in the aqueous solution contributes to success of phospha‐Michael reaction between β‐CF 3 ‐β,β‐disubstituted enones and diarylphosphine oxides, providing an access biologically relevant γ‐ketophosphine oxides bearing a sterically highly congested CF ‐ P(O)‐tetrasubstituted carbon center. More importantly, resulting products could be further transformed into densely functionalized containing

Язык: Английский

Процитировано

5

Synthesis of gem-Difluorohomoallyl Amines via a Transition-Metal-Free Defluorinative Alkylation of Benzyl Amines with Trifluoromethyl Alkenes DOI

Man Ren,

Shengjiao Yu,

Xuefeng Li

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(12), С. 8342 - 8356

Опубликована: Май 31, 2024

A mild and transition-metal-free defluorinative alkylation of benzyl amines with trifluoromethyl alkenes is reported. The features this protocol are easy-to-obtain starting materials, a wide range substrates, functional group tolerance as well high atom economy, thus offering strategy to access variety

Язык: Английский

Процитировано

1