The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(22), С. 16553 - 16563
Опубликована: Окт. 28, 2024
Defluorinative cyclization of CF
Язык: Английский
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(22), С. 16553 - 16563
Опубликована: Окт. 28, 2024
Defluorinative cyclization of CF
Язык: Английский
Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(14), С. 3974 - 3981
Опубликована: Янв. 1, 2024
A defluorinative cyclization of readily available trifluoromethyl enones with phosphine oxides for the synthesis polysubstituted furans is developed in a pure water solution.
Язык: Английский
Процитировано
10Green Chemistry, Год журнала: 2023, Номер 25(23), С. 9672 - 9679
Опубликована: Янв. 1, 2023
A H 2 O-promoted and (NH 4 ) CO 3 -enabled defluoroiminization reaction of fluoroalkyl alkenes for the synthesis fluoroalkylated 1,5-diazapentadienes has been developed.
Язык: Английский
Процитировано
17Organic Letters, Год журнала: 2023, Номер 25(42), С. 7595 - 7600
Опубликована: Окт. 13, 2023
O-Phosphination of α-dicarbonyls via sequential in situ formation a Kukhtin-Ramirez adduct and P(NMe2)3-catalyzed process has been exploited for the synthesis α-phosphoryloxy carbonyls. A range P(O)-H derivatives, including diarylphosphine oxides, arylphosphinates, phosphinates, are competent candidates to be introduced into this transformation, various carbonyls obtained. This approach possesses advantages mild conditions, simple operations, atom economy, high efficiency, gram-scale synthesis, which make it promising toolbox.
Язык: Английский
Процитировано
10Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(19), С. 3860 - 3865
Опубликована: Янв. 1, 2024
The aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient mild approach to access various α-aminoalkylphosphine in good yields tolerance functional groups using H 2 O as a clean solvent.
Язык: Английский
Процитировано
4Organic Letters, Год журнала: 2023, Номер 25(34), С. 6368 - 6373
Опубликована: Авг. 18, 2023
A chemo-, regio-, and stereoselective reaction of trifluoromethyl enones, phenylsilane, phosphine oxides through a sequential hydrodefluorination defluorophosphorylation relay is developed for the synthesis distinctive gem-fluorophosphine alkenes. This multicomponent occurred under transition-metal-free conditions with good functional group tolerance. Moreover, preinstalled carbonyl auxiliary important tuning reactivity β-trifluoromethyl thereby enabling controllable selective functionalization two fluorine atoms in trifluoromethylated enones.
Язык: Английский
Процитировано
9Tetrahedron, Год журнала: 2025, Номер unknown, С. 134705 - 134705
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(23)
Опубликована: Апрель 20, 2024
Abstract A tandem carbonyl reduction and hydrodefluorination of β‐trifluoromethyl enones with hydrosilanes under transition‐metal‐free conditions was developed for the synthesis a variety valuable gem ‐difluorovinyl alcohols. The hydrosilane could act as both reductive agent C(sp 3 )‐F bond‐breaking promoter mild reaction conditions. Synthetically useful organofluorides, such ‐fluorophosphine alkene, ketone, fluorinated dihydrofuran derivatives be readily constructed by further transformations obtained Moreover, method features conditions, operational simplicity, excellent functional group tolerance, scalability.
Язык: Английский
Процитировано
2Chemical Communications, Год журнала: 2024, Номер 60(51), С. 6548 - 6551
Опубликована: Янв. 1, 2024
The synthesis of deuterated
Язык: Английский
Процитировано
2Advanced Synthesis & Catalysis, Год журнала: 2023, Номер 365(20), С. 3546 - 3552
Опубликована: Сен. 16, 2023
Abstract The distinctive hydrophobic hydration effect in the aqueous solution contributes to success of phospha‐Michael reaction between β‐CF 3 ‐β,β‐disubstituted enones and diarylphosphine oxides, providing an access biologically relevant γ‐ketophosphine oxides bearing a sterically highly congested CF ‐ P(O)‐tetrasubstituted carbon center. More importantly, resulting products could be further transformed into densely functionalized containing
Язык: Английский
Процитировано
5The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(12), С. 8342 - 8356
Опубликована: Май 31, 2024
A mild and transition-metal-free defluorinative alkylation of benzyl amines with trifluoromethyl alkenes is reported. The features this protocol are easy-to-obtain starting materials, a wide range substrates, functional group tolerance as well high atom economy, thus offering strategy to access variety
Язык: Английский
Процитировано
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