Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(14), P. 3974 - 3981
Published: Jan. 1, 2024
A
defluorinative
cyclization
of
readily
available
trifluoromethyl
enones
with
phosphine
oxides
for
the
synthesis
polysubstituted
furans
is
developed
in
a
pure
water
solution.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(23), P. 9672 - 9679
Published: Jan. 1, 2023
A
H
2
O-promoted
and
(NH
4
)
CO
3
-enabled
defluoroiminization
reaction
of
fluoroalkyl
alkenes
for
the
synthesis
fluoroalkylated
1,5-diazapentadienes
has
been
developed.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(19), P. 3860 - 3865
Published: Jan. 1, 2024
The
aminophosphinoylation
of
alcohols
with
amines
and
H-phosphine
oxides
provides
an
efficient
mild
approach
to
access
various
α-aminoalkylphosphine
in
good
yields
tolerance
functional
groups
using
H
2
O
as
a
clean
solvent.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(42), P. 7595 - 7600
Published: Oct. 13, 2023
O-Phosphination
of
α-dicarbonyls
via
sequential
in
situ
formation
a
Kukhtin-Ramirez
adduct
and
P(NMe2)3-catalyzed
process
has
been
exploited
for
the
synthesis
α-phosphoryloxy
carbonyls.
A
range
P(O)-H
derivatives,
including
diarylphosphine
oxides,
arylphosphinates,
phosphinates,
are
competent
candidates
to
be
introduced
into
this
transformation,
various
carbonyls
obtained.
This
approach
possesses
advantages
mild
conditions,
simple
operations,
atom
economy,
high
efficiency,
gram-scale
synthesis,
which
make
it
promising
toolbox.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(34), P. 6368 - 6373
Published: Aug. 18, 2023
A
chemo-,
regio-,
and
stereoselective
reaction
of
trifluoromethyl
enones,
phenylsilane,
phosphine
oxides
through
a
sequential
hydrodefluorination
defluorophosphorylation
relay
is
developed
for
the
synthesis
distinctive
gem-fluorophosphine
alkenes.
This
multicomponent
occurred
under
transition-metal-free
conditions
with
good
functional
group
tolerance.
Moreover,
preinstalled
carbonyl
auxiliary
important
tuning
reactivity
β-trifluoromethyl
thereby
enabling
controllable
selective
functionalization
two
fluorine
atoms
in
trifluoromethylated
enones.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(23)
Published: April 20, 2024
Abstract
A
tandem
carbonyl
reduction
and
hydrodefluorination
of
β‐trifluoromethyl
enones
with
hydrosilanes
under
transition‐metal‐free
conditions
was
developed
for
the
synthesis
a
variety
valuable
gem
‐difluorovinyl
alcohols.
The
hydrosilane
could
act
as
both
reductive
agent
C(sp
3
)‐F
bond‐breaking
promoter
mild
reaction
conditions.
Synthetically
useful
organofluorides,
such
‐fluorophosphine
alkene,
ketone,
fluorinated
dihydrofuran
derivatives
be
readily
constructed
by
further
transformations
obtained
Moreover,
method
features
conditions,
operational
simplicity,
excellent
functional
group
tolerance,
scalability.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(20), P. 3546 - 3552
Published: Sept. 16, 2023
Abstract
The
distinctive
hydrophobic
hydration
effect
in
the
aqueous
solution
contributes
to
success
of
phospha‐Michael
reaction
between
β‐CF
3
‐β,β‐disubstituted
enones
and
diarylphosphine
oxides,
providing
an
access
biologically
relevant
γ‐ketophosphine
oxides
bearing
a
sterically
highly
congested
CF
‐
P(O)‐tetrasubstituted
carbon
center.
More
importantly,
resulting
products
could
be
further
transformed
into
densely
functionalized
containing
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 8342 - 8356
Published: May 31, 2024
A
mild
and
transition-metal-free
defluorinative
alkylation
of
benzyl
amines
with
trifluoromethyl
alkenes
is
reported.
The
features
this
protocol
are
easy-to-obtain
starting
materials,
a
wide
range
substrates,
functional
group
tolerance
as
well
high
atom
economy,
thus
offering
strategy
to
access
variety
