Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(39)
Опубликована: Май 13, 2024
Coumestan
represents
a
biologically
relevant
structural
motif
distributed
in
number
of
natural
products,
and
the
rapid
construction
related
derivatives
as
well
characterization
targets
would
accelerate
lead
compound
discovery
medicinal
chemistry.
In
this
work,
general
scalable
approach
to
8,9-dihydroxycoumestans
via
two-electrode
constant
current
electrolysis
was
developed.
The
application
two-phase
(aqueous/organic)
system
plays
crucial
role
for
success,
protecting
sensitive
o-benzoquinone
intermediates
from
over-oxidation.
Based
on
structurally
diverse
primary
SAR
study
coumestan
scaffold
completed,
3
r
exhibited
potent
antiproliferative
activities
robust
topoisomerase
I
(Top1)
inhibitory
activity.
Further
mechanism
studies
demonstrates
that
novel
Top1
poison,
which
might
open
an
avenue
development
Top1-targeted
antitumor
agent.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(9), С. 6117 - 6125
Опубликована: Апрель 24, 2024
The
first
paired
electrolysis-enabled
arylation
of
quinoxalin-2(1H)-ones
was
achieved
using
cyanoarenes
as
the
reagents.
A
variety
3-arylquinoxalin-2(1H)-ones
with
various
important
functional
groups
were
obtained
in
moderate
to
good
yields
under
metal-
and
chemical
oxidant-free
conditions.
With
a
pair
reductive
oxidative
processes
occurring
among
substrates
reaction
intermediates,
power
consumption
can
be
dramatically
reduced.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
11(2), С. 597 - 630
Опубликована: Ноя. 23, 2023
This
review
highlights
the
recent
progress
in
electrochemical
difunctionalization
of
alkenes
and
alkynes
involving
C–S/Se
bond
formation
to
access
organochalcogen
frameworks.
Chemical Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
In
this
study,
a
straightforward
and
environmentally
benign
electrochemical
mono-functionalization
of
alkenes
has
been
established
for
the
synthesis
alkenyl
selenium
sulfonates
using
elemental
as
source.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(8), С. 2306 - 2312
Опубликована: Янв. 1, 2024
Regioselective
electrochemical
C–H
sulfonylation–bromination
between
indolizines,
sodium
sulfinates,
and
KBr
has
been
established
in
an
undivided
cell,
which
serves
as
both
the
brominating
agent
electrolyte.
Green Chemistry,
Год журнала:
2024,
Номер
26(5), С. 2922 - 2927
Опубликована: Янв. 1, 2024
An
efficient
electrochemical
epoxidation
of
alkenes
catalyzed
by
(TMP)MnCl
with
water
as
the
oxygen
source
is
disclosed.
The
reaction
achieved
impressive
faradaic
efficiencies
(up
to
89%)
for
a
broad
range
substrates.
This
paper
reviews
progress
in
the
photochemical/electrochemical
construction
of
heterocyclic
compounds
using
CO
2
,
differentiating
between
various
reaction
types
and
elucidating
their
underlying
mechanisms
as
well
potential
applications.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(12), С. 1367 - 1372
Опубликована: Фев. 23, 2024
Comprehensive
Summary
The
selective
oxidative
sulfonylation
of
alkenes
with
selenium
sulfonate
depended
on
the
reaction
conditions.
electrochemical
C—H
proceeded
smoothly
to
afford
(
E
)‐vinyl
sulfones
good
selectivity
in
an
undivided
cell
without
external
oxidant.
While
aerobic
trifunctionalization
occurred
presence
KI
air,
which
provides
β
‐keto
selenosulfones
via
formation
C—O,
C—S,
and
C—Se
bonds
one‐pot.
Following
control
experiments,
a
plausible
mechanism
is
proposed
rationalize
experimental
results.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(12), С. 3485 - 3490
Опубликована: Янв. 1, 2024
Herein,
we
report
electrochemically
mediated
trifluoromethylallene
synthesis
via
the
rearrangement
of
trifluoromethyl-containing
1,3-enynes
under
action
silicon
or
boron
radicals,
with
good
selectivity
and
without
external
oxidants.
