Highly regio- and stereo-controlled synthesis of (Z)-4-(trifluoromethyl)-3-(phenylthio)-1-substituted-but-3-en-1-ynes via hydroalkynylation of alkynyl thioethers

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

We carried out the first reaction of palladium-catalyzed hydroalkynylation alkynylthioethers with terminal acetylenes.

Язык: Английский

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Trifluoromethyl Group (CF₃) Induced Regioselective Larock Indole Synthesis from Unsymmetric β-CF₃-1,3-enynes

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

The indole skeleton exists widely in natural products, pharmaceuticals, and materials. We disclose here a trifluoromethyl group induced regioselective Larock synthetic method from unsymmetric 2-CF3-1,3-enynes. presence of is determinable for the regioselectivity. Once CF3 was replaced with methyl or phenyl group, ratio 1:1 to 1:1.4 isomers were obtained. This strategy features good regioselectivity, broad substrate scope, high functional tolerance. protocol reported offers an alternative solution rare 3,4-functionalization products further transformed show distinctive reactivity hydroboration–oxidation hydro-bromination.

Язык: Английский

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Electrochemical 1,5-chlorosulfonylation and 1,5-hydrosulfonylation of vinylcyclopropanes

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(19), С. 5564 - 5572

Опубликована: Янв. 1, 2024

This study reports the electrochemical reaction of vinylcyclopropanes with sulfonyl chlorides, resulting in 1,5-hydrosulfonylation and 1,5-chlorosulfonylation.

Язык: Английский

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Copper-catalyzed perfluoroalkylation of propargyl gem-dichlorides

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

We developed a method for the copper-catalyzed coupling of propargyl gem -dichlorides with (DMPU) 2 Zn(R f ) to assemble chloro-substituted fluoroalkylated allenes. The reaction proceeds under mild conditions good functional group tolerance.

Язык: Английский

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