Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
Comprehensive
Summary
The
invention
of
novel
linkers
is
a
long‐lasting
task
in
the
area
sulfur(VI)
fluoride
exchange
reaction
(SuFEx).
Compared
with
most
frequently
investigated
sulfonyl
fluorides,
synthetic
accessibility
toward
its
mono‐aza
isostere,
i.e.
,
sulfonimidoyl
fluorides
still
limited.
Herein,
we
report
an
electrochemical
carbonfluorination
readily
available
N
‐sulfinylamines
to
access
various
aryl
and
alkyl
fluorides.
transformation
characterized
by
ready
availability
starting
materials,
mild
conditions,
obviating
metal
catalysts
chemical
oxidants.
ACS Catalysis,
Год журнала:
2024,
Номер
14(5), С. 3115 - 3127
Опубликована: Фев. 13, 2024
Although
the
transition
metal-catalyzed
radical
fluorine
atom
transfer
(FAT)
strategy
has
emerged
as
a
powerful
tool
for
construction
of
C–F
bonds,
to
our
knowledge,
this
approach
rarely
been
applied
formation
S–F
bonds.
Here,
we
report
that
4-methoxypyridine
1-oxide
can
serve
an
inexpensive
and
simple
yet
effective
ligand
thus
promote
transformation
copper-mediated
challengeable
FAT
sulfonyl
radicals,
paving
way
assembly
FSO2
group.
Based
on
concept,
three
Cu(I)-catalyzed
protocols
involving
site-selective
intra-
intermolecular
fluorosulfonylation
inert
C(sp3)–H
bonds
1,2-aminofluorosulfonylation
inactivated
alkenes
have
developed,
enabling
preparation
C(sp3)-rich
aliphatic
fluorides
cannot
be
easily
synthesized
by
known
methods.
These
practical
operationally
methods
result
in
high
functional
group
tolerance
under
mild
conditions
modification
bioactive
derivatives
highly
valued
molecules.
Detailed
mechanistic
studies
indicate
unique
role
facilitating
such
rare
FATs
via
outer-sphere
pathway.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(23)
Опубликована: Май 25, 2024
Abstract
Sulfonyl
fluorides
have
widespread
applications
in
many
fields,
including
organic
synthesis,
chemical
biology,
drug
discovery
and
materials
science.
In
particular,
the
past
decade,
a
number
of
aliphatic
sulfonyl
been
identified
showing
various
biological
activities.
These
appealing
features
brought
about
significant
advancement
developing
synthetic
methods
to
access
fluorides.
this
review,
we
will
discuss
recent
developments
radical
approaches
for
synthesis
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(15), С. 4318 - 4342
Опубликована: Янв. 1, 2024
This
review
primarily
focuses
on
the
generation
of
aryl
radicals
via
an
electroreduction
strategy,
and
systematically
elaborates
synthetic
applications,
scope,
limitations
substrates.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(10), С. 2762 - 2767
Опубликована: Янв. 1, 2024
A
P(NMe2)3-catalyzed
[4
+
2]
annulation
of
2-amino-β-nitrostyrenes
and
β′-acetoxy
allenoates
followed
by
a
Zn/AcOH-mediated
reduction–hydroamination–isomerization
has
been
developed.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 16, 2024
The
advancement
in
electrochemical
techniques
has
unlocked
a
new
path
for
achieving
unprecedented
oxidations
and
reductions
of
aryl
radical
precursors
controlled
selective
manner.
This
approach
facilitates
the
construction
aromatic
carbon-carbon
carbon-heteroatom
bonds.
In
light
green
merits
growing
importance
this
technique
chemistry,
review
aims
to
provide
an
overview
recent
advance
generation
radicals
organized
by
precursor
type,
with
focus
on
substrate
scope,
limitation,
underlying
mechanism,
thereby
inspiring
future
work
generation.
Organic Letters,
Год журнала:
2024,
Номер
26(13), С. 2662 - 2667
Опубликована: Март 26, 2024
A
novel
class
of
alkyne-tethered
amides
facilitates
an
unprecedented
photoinduced
palladium-catalyzed
radical
relay
formal
[5
+
2]
reaction.
This
innovative
strategy
allows
for
the
rapid
construction
diverse
fused
benzoazepine
structures,
yielding
structurally
and
compelling
compounds.
With
a
broad
substrate
scope
excellent
functional
group
tolerance,
methodology
synthesizes
biologically
active
Notably,
resulting
tricyclic
benzo[b]azepines
offer
diversification
opportunities
through
simple
transformations.
DFT
calculations
elucidate
seven-membered
ring
closure
mechanism
involving
alkenyl
Pd(I)
rebound
alongside
concerted
metalation–deprotonation
(CMD)
process.
Chemical Science,
Год журнала:
2024,
Номер
15(23), С. 8888 - 8895
Опубликована: Янв. 1, 2024
A
highly
efficient
method
achieves
precise
construction
of
alkyl
chiral
centers
at
remote
C3-positions
in
five-membered
S/O-heterocycles
via
cobalt-catalyzed
asymmetric
hydroalkylation
heterocyclic
alkenes.
Chemical Science,
Год журнала:
2024,
Номер
15(33), С. 13240 - 13249
Опубликована: Янв. 1, 2024
The
enantioselective
and
diastereoselective
synthesis
of
atropisomeric
hydrazides
with
defined
vicinal
central
axial
chirality
via
ternary
catalysis
in
a
one-pot
process
is
reported.
Alternating
current
electrolysis
has
emerged
as
a
promising
technique
for
addressing
challenging
redox
reactions
that
are
otherwise
difficult
or
impossible
direct
electrolysis.
Under
mild
and
transition-metal-free
reaction
conditions,
general
electrochemical
denitrative
cyclization
of
nitroarenes
was
developed
to
access
various
cyclic
sulfone-containing
derivatives
biological
significance.
The
key
success
lies
in
the
facile
manipulation
multiple
events
upon
rapid
alternating
polarity
switching
enhance
selectivity
efficiency.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(45)
Опубликована: Авг. 27, 2024
Abstract
Nitroarenes
are
fundamental
feedstocks
in
the
chemical
industry.
Their
relatively
inert
C−NO
2
bond
allows
for
late‐stage
modifications
of
molecules
and
exhibits
complete
orthogonality
to
reactivity
C‐halogen
cross‐coupling
reactions.
The
denitrative
functionalization
nitroarenes
holds
significant
appeal
due
it
avoids
use
aryl
halides,
thereby
simplifying
reaction
steps
improving
atom
step
economy.
Recent
progress
direct
includes
palladium‐catalyzed
coupling,
copper‐catalyzed
as
well
metal‐free
one‐pot
functionalization.
In
this
review,
we
provide
a
concise
overview
these
advancements,
detailing
features
mechanisms.
This
summary
aims
highlight
versatility
efficiency
methodologies,
offering
insights
into
their
potential
applications
inspiring
further
research
promising
area
organic
synthesis.
