RSC Advances,
Год журнала:
2024,
Номер
14(8), С. 5547 - 5565
Опубликована: Янв. 1, 2024
Spiro
heterocycle
frameworks
are
a
class
of
organic
compounds
that
possesses
unique
structural
features
making
them
highly
sought-after
targets
in
drug
discovery
due
to
their
diverse
biological
and
pharmacological
activities.
Abstract
Heterocycles
are
a
vital
class
of
compounds
in
numerous
fields,
including
drug
discovery,
agriculture,
and
materials
science.
Efficient
methods
for
the
synthesis
heterocycles
remain
critical
meeting
demands
these
industries.
Recent
advances
multicomponent
reactions
(MCRs)
utilizing
2‐aminobenzothiazole
(ABT)
have
shown
promising
results
formation
heterocycles.
The
versatility
this
context
has
enabled
rapid
efficient
construction
diverse
heterocyclic
structures.
Various
synthetic
methodologies
involving
discussed,
highlighting
its
importance
as
valuable
building
block
complex
potential
applications
discovery
material
science
also
explored.
Overall,
review
provides
comprehensive
overview
current
state
research
field
offers
insights
into
future
directions
area
study.
We
highlight
ABT
versatile
sustainable
starting
via
MCRs,
with
significant
implications
chemical
industry.
Abstract
This
review
provides
an
overview
of
the
recent
advances
in
synthesis
diverse
heterocyclic
compounds
using
thiosemicarbazide
as
a
key
building
block
via
multicomponent
reactions.
Thiosemicarbazide
is
versatile
reagent
that
has
gained
significant
attention
organic
due
to
its
ability
participate
reactions
for
efficient
and
sustainable
construction
assembly
novel
bioactive
molecules
pharmaceuticals.
discusses
potential
applications
future
directions
this
rapidly
evolving
area
research.
It
valuable
insights
into
innovative
approaches
heterocycles
thiosemicarbazide,
showcasing
significance
modern
chemistry
In
summary,
current
state
art,
highlighting
use
reported
between
2015
early
2024.
Ultrasonics Sonochemistry,
Год журнала:
2023,
Номер
102, С. 106741 - 106741
Опубликована: Дек. 23, 2023
Ultrasonic
irradiation
serves
as
a
vigorous
and
environmentally
sustainable
approach
for
augmenting
multicomponent
reactions
(MCRs),
offering
benefits
such
thermal
enhancement,
agitation,
activation,
among
others.
Malononitrile
emerges
versatile
reagent
in
this
context,
participating
myriad
of
MCRs
to
produce
structurally
diverse
heterocyclic
frameworks.
This
review
encapsulates
the
critical
role
malononitrile
sonochemical
synthesis
these
structures.
The
paper
further
delves
into
biochemical
pharmacological
implications
heterocycles,
elucidating
their
reaction
mechanisms
well
delineating
method's
scope
limitations.
We
furnish
an
overview
merits
challenges
inherent
synthetic
offer
insights
potential
avenues
future
research.
RSC Advances,
Год журнала:
2024,
Номер
14(9), С. 5907 - 5925
Опубликована: Янв. 1, 2024
New
pyrazolylindolin-2-one
linked
coumarin
derivatives
were
designed
as
dual
BRAF
V600E
/VEGFR-2
inhibitors
targeting
melanoma
cells
A375.
Docking
simulation
showed
various
interactions
with
the
binding
residues
in
and
VEGFR-2
active
sites.
Synthesis,
Год журнала:
2024,
Номер
56(16), С. 2445 - 2461
Опубликована: Янв. 8, 2024
Abstract
The
unique
reactivity
and
beneficial
features
of
the
5-aminotetrazole
synthon
(1H-tetrazol-5-amine)
have
made
it
a
versatile
effective
building
block
in
synthesis
heterocyclic
compounds.
In
addition,
several
drugs
containing
this
scaffold
with
wide
array
biological
properties
been
already
introduced.
Heterocyclic
structures
are
backbone
many
biologically
active
industrially
important
5-Aminotetrazole
is
one
favored
synthons
used
preparation
heterocycle-bearing
compounds,
especially
multicomponent
synthesis.
This
review
highlights
comprehensive
overview
emerging
applications
as
key
component
frameworks
through
reactions,
reported
between
2017
July
2023.
1
Introduction
2
3
Tetrazolopyrimidine
Compounds
4
Spiro
5
Miscellaneous
6
Conclusion
Natural Product Communications,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 1, 2025
Paramignya
trimera
(
P.
(Oliv.)
Guillaum),
a
Vietnamese
plant
has
showed
potential
anticancer
activities.
Extracts
from
the
plant's
roots,
stems,
and
leaves
have
shown
cytotoxicity
against
variety
of
cancer
cell
lines.
The
mechanisms
behind
these
actions
include
triggering
apoptosis,
blocking
invasion,
targeting
particular
signaling
pathways.
This
review
collected
data
available
literature
on
trimera's
properties
compiled
database
its
isolated
compounds.
Results
indicate
that
extracts
specific
compounds,
such
as
coumarins
acridones,
possess
potential.
Particularly,
acridones
exhibited
comparable
or
superior
HepG2
MCF-7
cells
(IC
50
values
0.43-1.19
μM
0.22-0.40
μM,
respectively)
compared
to
doxorubicin
0.28
1.31
μM).
Coumarins
like
8-geranylumbelliferone
ostruthin
target
IKKβ,
while
paratrimerin
W
shows
various
cancers.
Paratrimerin
I
exhibit
due
N-methyl,
C-4
methoxy,
C-5
hydroxy
groups
in
acridone
skeleton.
However,
further
research
is
needed
elucidate
precise
action
evaluate
safety
efficacy
trimera-derived
compounds
clinical
settings.
identification
146
provides
valuable
resource
for
future
drug
discovery
efforts.
Molecules,
Год журнала:
2025,
Номер
30(3), С. 651 - 651
Опубликована: Фев. 1, 2025
The
current
study
is
a
continuation
of
our
previous
investigations
into
the
radical
homodimeric
reaction
mechanism
3-acetylcoumarin.
In
study,
effects
different
substituents
on
coumarin
ring
3-acetylcoumarin
are
investigated
both
experimentally
and
theoretically.
Several
derivatives
(substituted
at
C-6,
C-7,
C-8)
were
tested
in
optimized
conditions
under
ultrasound
irradiation,
biscoumarin
species
isolated
characterized.
elucidation
substituent’s
effect
was
further
by
means
DFT
calculations
(free-energy
calculations,
NBO
analysis),
initial
substituted
coumarins
formed
radicals.
It
observed
that
presence
C-6
C-8
positions
moiety
would
not
affect
significantly
formation
radical,
while
group
position
C-7
could
either
stabilize
or
destabilize
depending
electronic
properties
substituent.
