Investigating novel tubulin polymerization inhibitors: design, synthesis, LC/MS cellular permeability, in silico studies, and in vitro assessment DOI
Iman A. Y. Ghannam, Islam H. Ali, Rasha Z. Batran

и другие.

Medicinal Chemistry Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Язык: Английский

Unveiling the potential of isatin-grafted phenyl-1,2,3-triazole derivatives as dual VEGFR-2/STAT-3 inhibitors: Design, synthesis and biological assessments DOI

Heba A. Elsebaie,

Maha-Hamadien Abdulla,

Zainab M. Elsayed

и другие.

Bioorganic Chemistry, Год журнала: 2024, Номер 151, С. 107626 - 107626

Опубликована: Июль 10, 2024

Язык: Английский

Процитировано

8
Design, synthesis and computational studies of new azaheterocyclic coumarin derivatives as anti-Mycobacterium tuberculosis agents targeting enoyl acyl carrier protein reductase (InhA) DOI Creative Commons
Rasha Z. Batran, Ahmed Sabt, Jarosław Dziadek

и другие.

RSC Advances, Год журнала: 2024, Номер 14(30), С. 21763 - 21777

Опубликована: Янв. 1, 2024

In this study, we designed and synthesized a series of coumarin derivatives as antitubercular agents targeting the enoyl acyl carrier protein reductase (InhA) enzyme. Among compounds, tetrazole derivative 4c showed most potent effect with minimum inhibitory concentration value (MIC) 15 μg mL-1 against Mtb H37Rv could also inhibit growth mutant strain (ΔkatG). Compound was able to penetrate Mtb-infected human macrophages suppress intracellular tubercle bacilli. Moreover, target InhA enzyme an IC50 0.565 μM, which superior reference inhibitor triclosan. Molecular docking compound within active site revealed importance 4-phenylcoumarin ring system moiety for activity. Finally, physicochemical properties pharmacokinetic parameters were investigated.

Язык: Английский

Процитировано

6
Undescribed diterpenes from Euphorbia mauritanica L. as modulators of the breast cancer resistance: Mechanistic and in silico studies DOI

Ahmed F. Essa,

Mai M. Elghonemy,

Rehab F. Taher

и другие.

Phytochemistry, Год журнала: 2025, Номер unknown, С. 114418 - 114418

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Synthesis and Mechanistic Insights of Coumarinyl-Indolinone Hybrids as Potent Inhibitors of Leishmania major DOI
Rasha Z. Batran, Manal S Ebaid, Sherry N. Nasralla

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117392 - 117392

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Exploring antitubercular activity of new coumarin derivatives targeting enoyl acyl carrier protein reductase (InhA): Synthesis, biological evaluation and computational studies DOI
Manal S Ebaid,

Małgorzata Korycka-Machała,

Moataz A. Shaldam

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142074 - 142074

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
New coumarin linked thiazole derivatives as antimycobacterial agents: Design, synthesis, enoyl acyl carrier protein reductase (InhA) inhibition and molecular modeling DOI
Asmaa F. Kassem, Ahmed Sabt,

Małgorzata Korycka-Machała

и другие.

Bioorganic Chemistry, Год журнала: 2024, Номер 150, С. 107511 - 107511

Опубликована: Май 31, 2024

Язык: Английский

Процитировано

3
Biosynthesis of selenium nanoparticles as a potential therapeutic agent in breast cancer: G2/M arrest and apoptosis induction DOI Creative Commons
Basant A. Ali, Rasha M. Allam, Mohamed S. Hasanin

и другие.

Toxicology Reports, Год журнала: 2024, Номер 13, С. 101792 - 101792

Опубликована: Окт. 25, 2024

Язык: Английский

Процитировано

2
Ursolic acid interaction with transcription factors BRAF, V600E, and V600K: a computational approach towards new potential melanoma treatments DOI
Giovanny Aguilera-Durán,

Stephanie Hernández-Castro,

Brenda V. Loera-García

и другие.

Journal of Molecular Modeling, Год журнала: 2024, Номер 30(11)

Опубликована: Окт. 10, 2024

Язык: Английский

Процитировано

0
Investigating novel tubulin polymerization inhibitors: design, synthesis, LC/MS cellular permeability, in silico studies, and in vitro assessment DOI
Iman A. Y. Ghannam, Islam H. Ali, Rasha Z. Batran

и другие.

Medicinal Chemistry Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Язык: Английский

Процитировано

0