Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(36), С. 7478 - 7484
Опубликована: Янв. 1, 2024
A
metal-free,
iodine-catalyzed
protocol
for
the
synthesis
of
biologically
significant
5-aroyl
1,2,4-oxadiazole
scaffolds
has
been
developed
using
aryl
methyl
ketones
and
amidoximes.
Abstract
1,4‐Naphthoquinones
(1,4‐NQs)
are
an
important
class
of
molecules
with
diverse
pharmaceutical
applications.
Lawsone,
a
naturally
occurring
molecule
range
bioactivities,
falls
in
the
1,4‐NQs.
It
possesses
1,3‐dicarbonyl
functionality,
which
has
been
utilized
synthesis
bis‐lawsones
reaction
aldehydes.
In
this
review
we
have
discussed
notable
developments
bis‐lawsone
from
2009
to
2023.
Also,
highlights
limitations
and
future
perspectives
area.
RSC Advances,
Год журнала:
2024,
Номер
14(30), С. 21269 - 21276
Опубликована: Янв. 1, 2024
A
green
and
sustainable
approach
has
been
developed
using
a
recyclable
reusable
LaF
3
·Pd
nanocatalyst.
This
catalyst
applied
in
the
synthesis
of
biaryls
good
to
excellent
yields
via
Suzuki
coupling
aqueous
medium.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Lawsone
is
a
popular
bioactive
natural
product.
1,3-Thiazoles
are
also
widely
distributed
in
many
products,
FDA-approved
drugs,
and
functional
materials.
We
report
herein
the
first
synthesis
of
naturally
occurring
lawsone-linked
fully
substituted
1,3-thiazoles
one-pot
multicomponent
reaction
(MCR)
arylglyoxals,
lawsone,
thiobenzamides
acetic
acid
at
90
°C,
affording
lawsone-1,3-thiazole
hybrids
excellent
yields
short
times.
The
advantages
present
method
include
facile,
robust,
easy
access
to
medicinally
relevant
diverse
array
hybrids,
isolation
product
by
filtration,
thereby
avoiding
column-chromatographic
purifications,
time,
metal-
catalyst-free
gram-scale
synthesis.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
An
iodine-catalyzed
aerobic
oxidation
reaction
of
C(sp3)-H
bonds
was
established
at
room
temperature.
In
this
transformation,
iodine
acts
as
a
Lewis
acid
catalyst,
and
the
pyridine
moiety
in
substrate
plays
crucial
role.
Under
optimum
conditions,
picolyl
ketone
substrates
were
smoothly
transformed
into
corresponding
1,2-dicarbonyl
compounds,
subsequent
introduction
1,2-diaminobenzenes
mixture
led
to
formation
various
quinoxaline
derivatives.
This
synthetic
process
does
not
use
transition
metals
also
features
mild
operational
simplicity,
gram-scale
synthesis.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 7, 2025
Propiolaldehyde,
the
most
reactive
yet
less
explored
electrophilic
acetylene,
was
generated
in
situ
via
a
base-free
Kornblum
oxidation
from
propargyl
tosylate
and
successfully
intercepted
with
hydrazones
affording
pyrazole-4-carboxaldehyde
one-pot
by
[3
+
2]
annulation
reaction.
Further,
endured
unique
cascade
reaction
phenylhydrazine
tosylate,
yielding
synthetically
challenging
bipyrazole
carboxaldehydes.
The
method
is
free
of
any
metal
catalyst,
base,
or
additives
offers
convenient
protocol
to
handle
volatile
propiolaldehyde
under
ambient
conditions.
RSC Advances,
Год журнала:
2025,
Номер
15(19), С. 15108 - 15115
Опубликована: Янв. 1, 2025
This
study
reports
a
metal-free,
three-component
synthesis
of
substituted
indolyl-1,3,4-thiadiazole
amines,
their
functionalization
into
diverse
N-heterocycles,
and
theoretical
evaluation
via
DFT
analysis.
Asian Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 20, 2025
Abstract
A
metal‐free,
iodine‐mediated
protocol
has
been
developed
to
synthesize
indazoloquinoxaline
derivatives
from
readily
accessible
substrates
such
as
2‐(2
H
‐indazol‐2‐yl)anilines
and
aryl
methyl
ketones.
This
operationally
simple,
one‐pot
reaction
proceeds
through
iodine/DMSO‐mediated
C(sp
3
)‐H
oxidation
of
ketones,
followed
by
imine
formation
annulation
furnish
the
desired
products.
wide
range
including
drug‐derived
substrates,
were
compatible
in
present
reaction.
Further,
is
scalable,
demonstrating
its
applicability
on
a
larger
scale.