I2-catalyzed tandem sp3 C–H oxidation and annulation of aryl methyl ketones with amidoximes for the synthesis of 5-aroyl-1,2,4-oxadiazoles DOI

Shiva Kumar Punna,

Mariyaraj Arockiaraj,

Venkatachalam Rajeshkumar

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(36), P. 7478 - 7484

Published: Jan. 1, 2024

A metal-free, iodine-catalyzed protocol for the synthesis of biologically significant 5-aroyl 1,2,4-oxadiazole scaffolds has been developed using aryl methyl ketones and amidoximes.

Language: Английский

Pseudo‐Multicomponent Reactions of Lawsone: Synthetic Strategies of Bis‐Lawsone DOI Open Access
Swadhin Swaraj Acharya,

Dibyaranjan Samantaray,

Chipuru Sibakrishna

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 1, 2025

Abstract 1,4‐Naphthoquinones (1,4‐NQs) are an important class of molecules with diverse pharmaceutical applications. Lawsone, a naturally occurring molecule range bioactivities, falls in the 1,4‐NQs. It possesses 1,3‐dicarbonyl functionality, which has been utilized synthesis bis‐lawsones reaction aldehydes. In this review we have discussed notable developments bis‐lawsone from 2009 to 2023. Also, highlights limitations and future perspectives area.

Language: Английский

Citations

1

Arylglyoxal-based multicomponent synthesis of C-3 functionalized imidazoheterocycles DOI
Swadhin Swaraj Acharya,

Rahul Kumar Sahoo,

Pralina Mohanty

et al.

Chemical Papers, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Language: Английский

Citations

4

Recyclable LaF3·Pd nanocatalyst in Suzuki coupling: green synthesis of biaryls from haloarenes and phenylboronic acids DOI Creative Commons

Smitabala Panda,

Sagarika Patra,

Swadhin Swaraj Acharya

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(30), P. 21269 - 21276

Published: Jan. 1, 2024

A green and sustainable approach has been developed using a recyclable reusable LaF 3 ·Pd nanocatalyst. This catalyst applied in the synthesis of biaryls good to excellent yields via Suzuki coupling aqueous medium.

Language: Английский

Citations

3

One-Pot Multicomponent Synthesis of Fully Substituted 1,3-Thiazoles Appended with Naturally Occurring Lawsone DOI
Swadhin Swaraj Acharya,

Bisal Kumar Guin,

Bibhuti Bhusan Parida

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Lawsone is a popular bioactive natural product. 1,3-Thiazoles are also widely distributed in many products, FDA-approved drugs, and functional materials. We report herein the first synthesis of naturally occurring lawsone-linked fully substituted 1,3-thiazoles one-pot multicomponent reaction (MCR) arylglyoxals, lawsone, thiobenzamides acetic acid at 90 °C, affording lawsone-1,3-thiazole hybrids excellent yields short times. The advantages present method include facile, robust, easy access to medicinally relevant diverse array hybrids, isolation product by filtration, thereby avoiding column-chromatographic purifications, time, metal- catalyst-free gram-scale synthesis.

Language: Английский

Citations

0

Iodine-Catalyzed Room-Temperature Aerobic Oxidation of C(sp3)–H Bonds and Its Application in the Synthesis of Quinoxaline Derivatives DOI

Hanyu Xiong,

Longxing Wang,

Yuanyang Mu

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

An iodine-catalyzed aerobic oxidation reaction of C(sp3)-H bonds was established at room temperature. In this transformation, iodine acts as a Lewis acid catalyst, and the pyridine moiety in substrate plays crucial role. Under optimum conditions, picolyl ketone substrates were smoothly transformed into corresponding 1,2-dicarbonyl compounds, subsequent introduction 1,2-diaminobenzenes mixture led to formation various quinoxaline derivatives. This synthetic process does not use transition metals also features mild operational simplicity, gram-scale synthesis.

Language: Английский

Citations

0

In Situ Generation and [3 + 2] Annulation Reactions of Propiolaldehyde─A Metal-Free, Cascade Route to Pyrazole and Bipyrazole Carboxaldehydes in One Pot DOI

Mariswamy K. Sreelekha,

Ali Shamnad, Rasmi P. Bhaskaran

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Propiolaldehyde, the most reactive yet less explored electrophilic acetylene, was generated in situ via a base-free Kornblum oxidation from propargyl tosylate and successfully intercepted with hydrazones affording pyrazole-4-carboxaldehyde one-pot by [3 + 2] annulation reaction. Further, endured unique cascade reaction phenylhydrazine tosylate, yielding synthetically challenging bipyrazole carboxaldehydes. The method is free of any metal catalyst, base, or additives offers convenient protocol to handle volatile propiolaldehyde under ambient conditions.

Language: Английский

Citations

0

Iodine-mediated synthesis of indolyl-1,3,4-thiadiazole amine derivatives and their DFT analysis DOI Creative Commons

Vartika Vaishya,

Manish Kumar Mehra, Sarvesh Kumar Pandey

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(19), P. 15108 - 15115

Published: Jan. 1, 2025

This study reports a metal-free, three-component synthesis of substituted indolyl-1,3,4-thiadiazole amines, their functionalization into diverse N-heterocycles, and theoretical evaluation via DFT analysis.

Language: Английский

Citations

0

I2/DMSO Mediated [5+1] Oxidative Annulation of Aryl Methyl Ketones with 2‐(2H‐Indazol‐2‐yl)anilines for the Synthesis of Indazoloquinoxalines DOI

Mariyaraj Arockiaraj,

Gargi Singh, Venkatachalam Rajeshkumar

et al.

Asian Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

Abstract A metal‐free, iodine‐mediated protocol has been developed to synthesize indazoloquinoxaline derivatives from readily accessible substrates such as 2‐(2 H ‐indazol‐2‐yl)anilines and aryl methyl ketones. This operationally simple, one‐pot reaction proceeds through iodine/DMSO‐mediated C(sp 3 )‐H oxidation of ketones, followed by imine formation annulation furnish the desired products. wide range including drug‐derived substrates, were compatible in present reaction. Further, is scalable, demonstrating its applicability on a larger scale.

Language: Английский

Citations

0

Green and Sustainable Synthesis of Biaryls Using LaPO4·Pd Recyclable Nanocatalyst by the Suzuki–Miyaura Coupling in Aqueous Medium DOI Creative Commons

Sagarika Patra,

Smitabala Panda,

Swadhin Swaraj Acharya

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: June 5, 2025

Language: Английский

Citations

0

Iodine-promoted sequential C(sp3)–H oxidation and cyclization of aryl methyl ketones with 2-(2-aminophenyl)quinazolin-4(3H)-ones DOI

Mariyaraj Arockiaraj,

Venkatachalam Rajeshkumar

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(34), P. 7052 - 7058

Published: Jan. 1, 2024

An I

Language: Английский

Citations

2