Pseudo‐Multicomponent Reactions of Lawsone: Synthetic Strategies of Bis‐Lawsone

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 1, 2025

Abstract 1,4‐Naphthoquinones (1,4‐NQs) are an important class of molecules with diverse pharmaceutical applications. Lawsone, a naturally occurring molecule range bioactivities, falls in the 1,4‐NQs. It possesses 1,3‐dicarbonyl functionality, which has been utilized synthesis bis‐lawsones reaction aldehydes. In this review we have discussed notable developments bis‐lawsone from 2009 to 2023. Also, highlights limitations and future perspectives area.

Language: Английский

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Arylglyoxal-based multicomponent synthesis of C-3 functionalized imidazoheterocycles

Chemical Papers, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Language: Английский

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Recyclable LaF₃·Pd nanocatalyst in Suzuki coupling: green synthesis of biaryls from haloarenes and phenylboronic acids

RSC Advances, Journal Year: 2024, Volume and Issue: 14(30), P. 21269 - 21276

Published: Jan. 1, 2024

A green and sustainable approach has been developed using a recyclable reusable LaF 3 ·Pd nanocatalyst. This catalyst applied in the synthesis of biaryls good to excellent yields via Suzuki coupling aqueous medium.

Language: Английский

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One-Pot Multicomponent Synthesis of Fully Substituted 1,3-Thiazoles Appended with Naturally Occurring Lawsone

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Lawsone is a popular bioactive natural product. 1,3-Thiazoles are also widely distributed in many products, FDA-approved drugs, and functional materials. We report herein the first synthesis of naturally occurring lawsone-linked fully substituted 1,3-thiazoles one-pot multicomponent reaction (MCR) arylglyoxals, lawsone, thiobenzamides acetic acid at 90 °C, affording lawsone-1,3-thiazole hybrids excellent yields short times. The advantages present method include facile, robust, easy access to medicinally relevant diverse array hybrids, isolation product by filtration, thereby avoiding column-chromatographic purifications, time, metal- catalyst-free gram-scale synthesis.

Language: Английский

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Iodine-Catalyzed Room-Temperature Aerobic Oxidation of C(sp³)–H Bonds and Its Application in the Synthesis of Quinoxaline Derivatives

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

An iodine-catalyzed aerobic oxidation reaction of C(sp3)-H bonds was established at room temperature. In this transformation, iodine acts as a Lewis acid catalyst, and the pyridine moiety in substrate plays crucial role. Under optimum conditions, picolyl ketone substrates were smoothly transformed into corresponding 1,2-dicarbonyl compounds, subsequent introduction 1,2-diaminobenzenes mixture led to formation various quinoxaline derivatives. This synthetic process does not use transition metals also features mild operational simplicity, gram-scale synthesis.

Language: Английский

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In Situ Generation and [3 + 2] Annulation Reactions of Propiolaldehyde─A Metal-Free, Cascade Route to Pyrazole and Bipyrazole Carboxaldehydes in One Pot

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Propiolaldehyde, the most reactive yet less explored electrophilic acetylene, was generated in situ via a base-free Kornblum oxidation from propargyl tosylate and successfully intercepted with hydrazones affording pyrazole-4-carboxaldehyde one-pot by [3 + 2] annulation reaction. Further, endured unique cascade reaction phenylhydrazine tosylate, yielding synthetically challenging bipyrazole carboxaldehydes. The method is free of any metal catalyst, base, or additives offers convenient protocol to handle volatile propiolaldehyde under ambient conditions.

Language: Английский

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Iodine-mediated synthesis of indolyl-1,3,4-thiadiazole amine derivatives and their DFT analysis

RSC Advances, Journal Year: 2025, Volume and Issue: 15(19), P. 15108 - 15115

Published: Jan. 1, 2025

This study reports a metal-free, three-component synthesis of substituted indolyl-1,3,4-thiadiazole amines, their functionalization into diverse N-heterocycles, and theoretical evaluation via DFT analysis.

Language: Английский

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I₂/DMSO Mediated [5+1] Oxidative Annulation of Aryl Methyl Ketones with 2‐(2H‐Indazol‐2‐yl)anilines for the Synthesis of Indazoloquinoxalines

Asian Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

Abstract A metal‐free, iodine‐mediated protocol has been developed to synthesize indazoloquinoxaline derivatives from readily accessible substrates such as 2‐(2 H ‐indazol‐2‐yl)anilines and aryl methyl ketones. This operationally simple, one‐pot reaction proceeds through iodine/DMSO‐mediated C(sp 3 )‐H oxidation of ketones, followed by imine formation annulation furnish the desired products. wide range including drug‐derived substrates, were compatible in present reaction. Further, is scalable, demonstrating its applicability on a larger scale.

Language: Английский

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Green and Sustainable Synthesis of Biaryls Using LaPO₄·Pd Recyclable Nanocatalyst by the Suzuki–Miyaura Coupling in Aqueous Medium

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: June 5, 2025

Language: Английский

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Iodine-promoted sequential C(sp3)–H oxidation and cyclization of aryl methyl ketones with 2-(2-aminophenyl)quinazolin-4(3H)-ones

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(34), P. 7052 - 7058

Published: Jan. 1, 2024

An I

Language: Английский

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