TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер unknown, С. 118106 - 118106
Опубликована: Дек. 1, 2024
Язык: Английский
Materials Science and Engineering B, Год журнала: 2024, Номер 301, С. 117191 - 117191
Опубликована: Янв. 13, 2024
Язык: Английский
Процитировано
60
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 5, 2025
Abstract Inspired by the emerging potential of photoluminescent hydrogels, this work unlocks new avenues for advanced biosensing, bioimaging, and drug delivery applications. Carbon quantum dots (CDs) are deemed particularly promising among various optical dyes, enhancing polymeric networks with superior physical chemical properties. This study presents synthesis CDs derived from Prunella vulgaris , a natural plant resource, through single‐step hydrothermal process, followed their uniform integration into hydrogel matrices via an in situ free radical graft polymerization. The resulting CD‐integrated hydrogels exhibit multifunctionality biomedical applications, featuring diffusion‐controlled release mechanism, permit concurrent therapeutic agents, enabling real‐time monitoring over 32 h. In addition, these function as broad‐range pH sensor (pH 3–11), provide robust ultraviolet (UV) shielding, demonstrate nanozyme‐like peroxidase activity. Critically, biocompatibility tests confirm non‐cytotoxicity toward fibroblast cells, establishing candidates diverse These include wound dressings that monitor healing process detect infection sensing, promote nanozymatic activity, all while maintaining moist microenvironment. exceptional suitability smart delivery, effective UV‐blocking, innovative platforms vivo sensing bioimaging.
Язык: Английский
Процитировано
3
Cancer Letters, Год журнала: 2024, Номер 588, С. 216782 - 216782
Опубликована: Март 6, 2024
Pancreatic cancer poses a significant challenge within the field of oncology due to its aggressive behaviour, limited treatment choices, and unfavourable outlook. With mere 10% survival rate at 5-year mark, finding effective interventions becomes even more pressing. The intricate relationship between desmoplasia hypoxia in tumor microenvironment further complicates matters by promoting resistance chemotherapy impeding efficacy. dense extracellular matrix cancer-associated fibroblasts characteristic create physical biochemical barrier that impedes drug penetration fosters an immunosuppressive milieu. Concurrently, nurtures behaviour conventional therapies. comprehensive exploration emerging medications innovative delivery approaches. Notably, advancements nanoparticle-based systems, local implants, oxygen-carrying strategies are highlighted for their potential enhance accessibility therapeutic outcomes. integration these with traditional chemotherapies targeted agents reveals synergistic effects amplify responses. These can mitigate hypoxia-induced barriers, leading improved delivery, efficacy, patient outcomes pancreatic cancer. This review article delves into dynamic landscape anticancer poised overcome challenges imposed
Язык: Английский
Процитировано
10
Cancer Cell International, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 18, 2025
Abstract Researchers have found that mutations in the BRCA gene associated with breast cancer a 40–50% chance of being high risk for hereditary (BC). Therefore, detecting BRCA1 is crucial genetic analysis, early detection, and clinical treatment BC. Traditional detection methods include high-performance liquid chromatography (HPLC), single-strand conformation polymorphism assays (SSCP), PCR, real-time DNA sequencing. However, these are limited by cost, analysis time, complexity. it necessary to develop an ultrasensitive, fast, low-cost, simple method detection. In recent years, various BC biosensing strategies been investigated, including optical, electrical, electrochemical, mechanical biosensing. particular, sensitivity short times electrochemical biosensors make them suitable recognizing biomarkers. Additionally, can be increased incorporating nanomaterials. this regard, main focus present study introduction common diagnosing BRCA-1/2 genes. addition introducing as efficient tool, also discusses latest most significant developed gene.
Язык: Английский
Процитировано
1
Carbohydrate Polymer Technologies and Applications, Год журнала: 2025, Номер unknown, С. 100695 - 100695
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2023, Номер 6(24), С. 23184 - 23195
Опубликована: Ноя. 30, 2023
This study presents the pH-responsive nanoplatform DOX@M-MSN-5-FAM@PDA (DM-F@P) to improve treatment of pancreatic cancer. DM-F@P is a combination magnetic mesoporous silica nanoparticles (M-MSN) and polydopamine (PDA) outer layer ensure controlled delivery loaded drugs. The doxorubicin (DOX) 5-carboxyfluorescein (5-FAM) fluorescent dyes in imparts chemotherapy fluorescence imaging capabilities. PDA shell permits release DOX, specifically tumor microenvironment, thereby enabling accurate treatment. Moreover, highly biocompatible. In vitro vivo research has confirmed powerful effectiveness against cancer its minimal toxicity toward normal cells. Additionally, Fe3O4 component enabled resonance (MRI). innovative nanomaterial provides an integrated diagnostic platform that combines therapeutic capabilities; therefore, it considered modality facilitates diagnosis
Язык: Английский
Процитировано
7
Industrial Crops and Products, Год журнала: 2024, Номер 218, С. 118815 - 118815
Опубликована: Июнь 16, 2024
Язык: Английский
Процитировано
2
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Июнь 22, 2024
Pancreatic cancer is one of the most aggressive forms cancer, and treatment options are limited. One therapeutic approach to use nanoparticles deliver active agent directly pancreatic cells. Nanoparticles can be designed specifically target cells, minimizing damage healthy tissues. Silver have unique ability absorb light, especially in near-infrared (NIR) region. In this study, silver functionalized with IgG molecules were synthesized administered cell lines. Subsequently, cells photo-excited using a 2 W 808 nm laser further examined PANC-1 Flow cytometry confocal microscopy combined immunochemical staining used examine interaction between The photothermal therapy based on IgG-functionalized induces dysfunction Golgi apparatus, leading activation caspase-3 apoptotic pathway ultimately resulting cellular apoptosis. These findings suggest that our proposed nanoparticle could emerge as novel for cancer.
Язык: Английский
Процитировано
2
Molecules, Год журнала: 2023, Номер 28(22), С. 7565 - 7565
Опубликована: Ноя. 13, 2023
Apigenin (API) possesses excellent antitumor properties but its limited water solubility and low bioavailability restrict therapeutic impact. Thus, a suitable delivery system is needed to overcome these limitations improve the efficiency. Poly (lactic-co-glycolic acid) (PLGA) copolymer extensively utilized in drug delivery. Hyaluronic acid (HA) major extracellular matrix component can specifically bind CD44 on colon cancer cells. Herein, we aimed prepare receptor-selective HA-coated PLGA nanoparticles (HA-PLGA-API-NPs) for cancers with high expression of CD44; chitosan (CS) was introduced into as an intermediate, simultaneously binding HA through electrostatic interaction facilitate tighter connection between them. API encapsulated obtain PLGA-API-NPs, which were then sequentially coated CS form HA-PLGA-API-NPs. HA-PLGA-API-NPs had stronger sustained-release capability. The cellular uptake enhanced HT-29 cells CD44. In vivo, showed targeting specificity towards ectopic tumor model nude mice comparison PLGA-API-NPs. Overall, effective platform treatment
Язык: Английский
Процитировано
5
Materials Research Innovations, Год журнала: 2024, Номер 28(6), С. 478 - 492
Опубликована: Март 6, 2024
Graphene is a unique nanocarbon nanostructure which commonly used to form the nanocomposites. Green strategies (chemical vapour deposition with green catalysts, mechanical exfoliation, sonication) and sustainable carbon sources (plant extracts recycled polymers) have been applied synthesise graphene derivatives. For formation of nanocomposites, fabrication methods (sonication, solution route, electrostatic, in situ polymerisation, printing, hydrothermal, etc.) involving matrices, nanofillers, solvents, reagents, also investigated. Thus, this state-of-the-art overview highlights essential for nanomaterials. The resulting nanocomposites numerous superior structural physical properties such as morphology, electrical conductivity, thermal stability, stability. Subsequently, synthesised explored important high performance technical applications including energy storage, packaging, antibacterial, bioimaging, drug delivery applications. Future research on development advanced synthesis may overcome design challenges
Язык: Английский
Процитировано
1