Science China Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 13, 2024
Abstract
Photodynamic
therapy
(PDT)
is
a
promising
cancer
treatment
that
uses
photosensitizers
(PSs)
to
generate
cytotoxic
reactive
oxygen
species
(ROS)
under
light,
but
improving
its
efficacy
crucial
for
clinical
applications.
To
address
this,
we
propose
smart
nanoplatform
(P@BAO-DOX)
synergistic
chemo-photodynamic
therapy,
featuring
efficient
PDT,
controllable
drug
release,
and
fluorescence
imaging
guidance.
We
designed
an
aggregation-induced
emission
(AIE)-based
PS
(BAO)
with
effective
ROS
generation
NIR-II
fluorescence.
Additionally,
BAO
as
doxorubicin
(DOX)
chemo
were
encapsulated
in
pH-responsive
nanogels
(PNA)
obtain
P@BAO-DOX
nanogels.
Upon
uptake
by
tumor
cells,
the
nanogel
releases
drugs
acidic
conditions,
leading
cell
death.
White
light
irradiation
further
triggers
produce
substantial
ROS,
enhancing
phototoxicity
chemo-PDT
therapy.
Thus,
nanogels,
nanoplatform,
offer
precise
release
imaging-guided
showing
promise
advancing
treatment.
Materials Today Bio,
Год журнала:
2024,
Номер
27, С. 101149 - 101149
Опубликована: Июль 9, 2024
Renal
cell
carcinoma
(RCC)
is
recognized
as
one
of
the
three
primary
malignant
tumors
affecting
urinary
system,
posing
a
significant
risk
to
human
health
and
life.
Despite
advancements
in
understanding
RCC,
challenges
persist
its
diagnosis
treatment,
particularly
early
detection
due
issues
low
specificity
sensitivity.
Consequently,
there
an
urgent
need
for
development
effective
strategies
enhance
diagnostic
accuracy
treatment
outcomes
RCC.
In
recent
years,
with
extensive
research
on
materials
applications
biomedical
field,
some
have
been
identified
promising
clinical
applications,
e.g.,
many
tumors,
including
Herein,
we
summarize
latest
that
are
being
studied
applied
While
focusing
their
adjuvant
effects,
also
discuss
technical
principles
safety,
thus
highlighting
value
potential
application.
addition,
limitations
application
these
possible
future
directions,
providing
new
insights
improving
RCC
treatment.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 7399 - 7414
Опубликована: Июль 1, 2024
Background:
Influenza
A
(H1N1)
virus
is
a
highly
contagious
respiratory
disease
that
causes
severe
illness
and
death.
Vaccines
antiviral
drugs
are
limited
by
viral
variation
drug
resistance,
so
developing
efficient
integrated
theranostic
options
appears
significant
in
anti-influenza
infection.
Methods:
In
this
study,
we
designed
fabricated
covalent
organic
framework
(COF)
based
platforms
(T705@DATA-COF-Pro),
which
was
composed
of
an
RNA
polymerase
inhibitor
(favipiravir,
T705),
the
carboxyl-enriched
COF
(DATA-COF)
nano-carrier
Cy3-labeled
single
DNA
(ssDNA)
probe.
Results:
The
multi-porosity
core
provided
excellent
micro-environment
smooth
delivery
for
T705.
ssDNA
probe
coating
bound
to
nucleic
acids
H1N1
selectively,
thus
controlling
release
allowing
fluorescence
imaging.
combination
triggered
synergism,
promoting
further
therapeutic
outcomes.
With
aid
T705@DATA-COF-Pro
platforms,
H1N1-infected
mouse
models
lightly
achieved
diagnosis
significantly
prolonged
survival.
Conclusion:
This
research
underscores
distinctive
benefits
immense
potential
materials
nano-preparations
infection,
offering
novel
avenues
detection
treatment
Keywords:
crystal
porous
materials,
microenvironment-responsive,
controlled
release,
imaging,
therapy
Science China Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 13, 2024
Abstract
Photodynamic
therapy
(PDT)
is
a
promising
cancer
treatment
that
uses
photosensitizers
(PSs)
to
generate
cytotoxic
reactive
oxygen
species
(ROS)
under
light,
but
improving
its
efficacy
crucial
for
clinical
applications.
To
address
this,
we
propose
smart
nanoplatform
(P@BAO-DOX)
synergistic
chemo-photodynamic
therapy,
featuring
efficient
PDT,
controllable
drug
release,
and
fluorescence
imaging
guidance.
We
designed
an
aggregation-induced
emission
(AIE)-based
PS
(BAO)
with
effective
ROS
generation
NIR-II
fluorescence.
Additionally,
BAO
as
doxorubicin
(DOX)
chemo
were
encapsulated
in
pH-responsive
nanogels
(PNA)
obtain
P@BAO-DOX
nanogels.
Upon
uptake
by
tumor
cells,
the
nanogel
releases
drugs
acidic
conditions,
leading
cell
death.
White
light
irradiation
further
triggers
produce
substantial
ROS,
enhancing
phototoxicity
chemo-PDT
therapy.
Thus,
nanogels,
nanoplatform,
offer
precise
release
imaging-guided
showing
promise
advancing
treatment.
