pH-responsive AIE nanogels for synergistic chemo-photodynamic cancer therapy with imaging guidance DOI Creative Commons

Yilin Zhu,

Liping Zhang, Rongyuan Zhang

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Abstract Photodynamic therapy (PDT) is a promising cancer treatment that uses photosensitizers (PSs) to generate cytotoxic reactive oxygen species (ROS) under light, but improving its efficacy crucial for clinical applications. To address this, we propose smart nanoplatform (P@BAO-DOX) synergistic chemo-photodynamic therapy, featuring efficient PDT, controllable drug release, and fluorescence imaging guidance. We designed an aggregation-induced emission (AIE)-based PS (BAO) with effective ROS generation NIR-II fluorescence. Additionally, BAO as doxorubicin (DOX) chemo were encapsulated in pH-responsive nanogels (PNA) obtain P@BAO-DOX nanogels. Upon uptake by tumor cells, the nanogel releases drugs acidic conditions, leading cell death. White light irradiation further triggers produce substantial ROS, enhancing phototoxicity chemo-PDT therapy. Thus, nanogels, nanoplatform, offer precise release imaging-guided showing promise advancing treatment.

Language: Английский

Exploring biogenic/ green solvents on the sustainable development of Metal Organic Frameworks for waste water treatment DOI Creative Commons
Rajeev Agrawal, Urmila Chakraborty, Saurabh Singh

et al.

Current Research in Green and Sustainable Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 100462 - 100462

Published: May 1, 2025

Language: Английский

Citations

0
Metal-organic frameworks treating diabetic skin wounds by endogenous/exogenous responses DOI Creative Commons
Liang Chen, Lingling Wu, Mao Xie

et al.

Next Nanotechnology, Journal Year: 2025, Volume and Issue: 7, P. 100177 - 100177

Published: Jan. 1, 2025

Language: Английский

Citations

0
Effective strategies to enhance the diagnosis and treatment of RCC: The application of biocompatible materials DOI Creative Commons
Jinxin Li,

Peng Luo,

Shiyang Liu

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 27, P. 101149 - 101149

Published: July 9, 2024

Renal cell carcinoma (RCC) is recognized as one of the three primary malignant tumors affecting urinary system, posing a significant risk to human health and life. Despite advancements in understanding RCC, challenges persist its diagnosis treatment, particularly early detection due issues low specificity sensitivity. Consequently, there an urgent need for development effective strategies enhance diagnostic accuracy treatment outcomes RCC. In recent years, with extensive research on materials applications biomedical field, some have been identified promising clinical applications, e.g., many tumors, including Herein, we summarize latest that are being studied applied While focusing their adjuvant effects, also discuss technical principles safety, thus highlighting value potential application. addition, limitations application these possible future directions, providing new insights improving RCC treatment.

Language: Английский

Citations

2
Covalent Organic Framework-Based Theranostic Platforms for Restricting H1N1 Influenza Virus Infection DOI Creative Commons

Luo‐Gang Ding,

Xiang Ji, Yueyue Liu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7399 - 7414

Published: July 1, 2024

Background: Influenza A (H1N1) virus is a highly contagious respiratory disease that causes severe illness and death. Vaccines antiviral drugs are limited by viral variation drug resistance, so developing efficient integrated theranostic options appears significant in anti-influenza infection. Methods: In this study, we designed fabricated covalent organic framework (COF) based platforms (T705@DATA-COF-Pro), which was composed of an RNA polymerase inhibitor (favipiravir, T705), the carboxyl-enriched COF (DATA-COF) nano-carrier Cy3-labeled single DNA (ssDNA) probe. Results: The multi-porosity core provided excellent micro-environment smooth delivery for T705. ssDNA probe coating bound to nucleic acids H1N1 selectively, thus controlling release allowing fluorescence imaging. combination triggered synergism, promoting further therapeutic outcomes. With aid T705@DATA-COF-Pro platforms, H1N1-infected mouse models lightly achieved diagnosis significantly prolonged survival. Conclusion: This research underscores distinctive benefits immense potential materials nano-preparations infection, offering novel avenues detection treatment Keywords: crystal porous materials, microenvironment-responsive, controlled release, imaging, therapy

Language: Английский

Citations

1
pH-responsive AIE nanogels for synergistic chemo-photodynamic cancer therapy with imaging guidance DOI Creative Commons

Yilin Zhu,

Liping Zhang, Rongyuan Zhang

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Abstract Photodynamic therapy (PDT) is a promising cancer treatment that uses photosensitizers (PSs) to generate cytotoxic reactive oxygen species (ROS) under light, but improving its efficacy crucial for clinical applications. To address this, we propose smart nanoplatform (P@BAO-DOX) synergistic chemo-photodynamic therapy, featuring efficient PDT, controllable drug release, and fluorescence imaging guidance. We designed an aggregation-induced emission (AIE)-based PS (BAO) with effective ROS generation NIR-II fluorescence. Additionally, BAO as doxorubicin (DOX) chemo were encapsulated in pH-responsive nanogels (PNA) obtain P@BAO-DOX nanogels. Upon uptake by tumor cells, the nanogel releases drugs acidic conditions, leading cell death. White light irradiation further triggers produce substantial ROS, enhancing phototoxicity chemo-PDT therapy. Thus, nanogels, nanoplatform, offer precise release imaging-guided showing promise advancing treatment.

Language: Английский

Citations

1