Metal-free synthesis of carbamoylated dihydroquinolinones via cascade radical annulation of cinnamamides with oxamic acids
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(9), С. 1821 - 1833
Опубликована: Янв. 1, 2024
Metal-free
synthesis
of
medicinally
important
carbamoylated
dihydroquinolinones
using
readily
available,
cheap
and
environment-friendly
materials
with
good
to
excellent
yields.
Язык: Английский
Base-Promoted [4 + 1 + 1] Multicomponent Tandem Cycloaddition of Ortho-Substituted Nitroarenes, Aldehydes, and Ammonium Salts To Access 2,4-Substituted Quinazoline Frameworks
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
90(5), С. 1982 - 1995
Опубликована: Янв. 23, 2025
We
report
a
base-promoted,
metal-free
multicomponent
tandem
reaction,
involving
[4
+
1
1]
cycloaddition
process
between
ortho-substituted
nitroarenes,
aldehydes,
and
ammonium
salts.
Modifying
the
substituents
on
nitroaromatic
compounds
effectively
provides
structurally
diverse
2-substituted
4-alkenylquinazolines
with
good
to
excellent
yields
(77%-90%
quinazoline
51
examples)
high
tolerance
for
various
inorganic
salts
(13
examples,
such
as
NH3·H2O,
NH4Cl,
NH4HF2).
A
new
method
constructing
2,4-substituted
selectivity
from
simple
nitrogen
source
was
developed,
reaction
can
be
scaled
up
gram
scale.
Additionally,
this
also
facilitates
preparation
of
organic
molecules
photophysical
properties,
offering
insights
into
further
transformation
quinazolines.
Язык: Английский
Visible-light-induced three-component reactions of α-diazoesters, quinazolinones and cyclic ethers toward quinazoline-based hybrids
Yan Liu,
Qin Yang,
Wei Wang
и другие.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(21), С. 4332 - 4346
Опубликована: Янв. 1, 2024
Visible-light-induced
three-component
reactions,
which
were
performed
under
extremely
mild
conditions
without
the
need
for
any
additional
additives
and
catalysts
showed
a
broad
substrate
scope,
gave
corresponding
quinazoline-based
hybrids
in
good
to
excellent
yields.
Язык: Английский
Metal‐Free Regioselective Direct C(4)−H Amination of Quinazoline with N‐fluorobenzenesulfonimide
ChemPlusChem,
Год журнала:
2024,
Номер
89(11)
Опубликована: Июль 18, 2024
Abstract
A
facile
C−H
amination
of
quinazoline
employing
N
‐fluorobenzenesulfonimide
(NFSI)
as
the
source
has
been
disclosed
in
absence
any
metal,
oxidant
or
additive.
The
methodology
shows
a
board
range
quinazolines
with
different
functional
groups
moderate
to
good
yields
up
87
%.
Furthermore,
gram‐scale
reaction,
desulfonylation
amine
and
synthesis
pharmaceutical
intermediate
were
also
investigated,
which
demonstrates
potential
applications
medicinal
chemistry.
plausible
mechanism
is
proposed
via
F
+
transfer
accompanied
by
removal
one
molecule
PhSO
2
F.
DFT
studies
experimental
work
suggest
that
more
favorable
than
free
radical
one.
Язык: Английский
Metal-free, direct acylation of purines to access C6-acylated purine derivatives induced by TBHP via Minisci-type reaction
New Journal of Chemistry,
Год журнала:
2024,
Номер
48(12), С. 5167 - 5172
Опубликована: Янв. 1, 2024
The
highly
C
6
-regioselective
acylation
of
purines
with
aldehydes
was
developed
to
access
-acylated
via
green
radical
reactions
without
metal
catalysts
or
light.
Язык: Английский
Ag-Catalyzed Cross-Dehydrogenative-Coupling for the Synthesis of 1,4-Dioxan-2yl Substituted Qunazoline Hybrids in Aqueous Media
Xixian Liu,
Dayu Xie,
Qin Yang
и другие.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(37), С. 7725 - 7735
Опубликована: Янв. 1, 2024
We
herein
developed
an
effective
approach
for
the
construction
of
2-
or
4-(1,4-dioxan-2-yl)
substituted
quinazolines
under
mild
conditions.
A
silver-K
Язык: Английский
Six-membered ring systems: Diazines and benzo derivatives
Progress in heterocyclic chemistry,
Год журнала:
2024,
Номер
unknown, С. 355 - 393
Опубликована: Янв. 1, 2024
Electrochemical Synthesis of Quinazolines: N–H/C(sp3)–H Coupling of o-Carbonyl Anilines with Amino Acids and Amines
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
A
mild
and
efficient
electrochemical
protocol
for
the
synthesis
of
quinazolines
through
N-H/C(sp
Язык: Английский