MnFe₂O₄ Nanoparticles‐Catalyzed C3‐Alkylation of Indoles with Benzyl Alcohols under Solvent‐Free Conditions

ChemistrySelect, Год журнала: 2024, Номер 9(33)

Опубликована: Авг. 28, 2024

Abstract Herein, we present an efficient, one‐pot reaction for accessing 3‐benzylated indoles via the coupling of benzyl alcohols with under heterogeneous catalysis by manganese ferrite (MnFe 2 O 4 ) nanoparticles. Notably, this reaction, first time, employs MnFe nanoparticles prepared using a simple grinding method. The high compatibility enables broad substrate scope and regioselectivity. Moreover, approach offers several attractive highlights including use recyclable oxide catalyst green cost‐effective alkylating reagents solvent‐free conditions.

Язык: Английский

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Synthesis and Biological Analysis of Iso-dimethyltryptamines in a Model of Light-Induced Retinal Degeneration

ACS Medicinal Chemistry Letters, Год журнала: 2024, Номер 15(7), С. 1049 - 1056

Опубликована: Июнь 13, 2024

Iso-dimethyltryptamine (isoDMT) analogues with heterocyclic substitutions at the indole C(3) were prepared in a hydrogen autotransfer alkylation and tested combination natural unnatural clavine alkaloids model of light-induced retinal degeneration for protection against degeneration. On basis measurements optical coherence tomography electroretinography, three compounds showed better efficacy than positive control bromocriptine equivalent systemically administered doses. These studies provide further insights into role serotonin receptors their potential therapeutic applications ocular diseases.

Язык: Английский

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Substrate-Induced Cooperative Ionic Catalysis: Difunctionalization of Indole Derivatives Employing Dimethyl Carbonate

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(21), С. 15995 - 16003

Опубликована: Окт. 21, 2024

The global urge to adopt sustainable chemistry has resulted in the development of more environmentally benign strategies (EBS) that use CO2 and CO2-derived chemicals a step-economic manner. In this context, we investigated dual C–H methylation (C═O)-methoxylation indole derivatives using dimethyl carbonate (DMC) presence catalytic amounts Cs2CO3. Mechanistic insights include DMF-assisted, DMC-induced cooperative ionic catalysis, which allows DMC act as both nucleophilic an electrophilic precursor, resulting N-benzylindolyl ketones.

Язык: Английский

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Five-membered ring systems: Pyrroles and benzo analogs

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 123 - 173

Опубликована: Янв. 1, 2024

Язык: Английский

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