Substrate-Induced Cooperative Ionic Catalysis: Difunctionalization of Indole Derivatives Employing Dimethyl Carbonate DOI
Sangita Dattatray Shinde,

Asma Poudel Chhetri,

Sayak Ghosh

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(21), P. 15995 - 16003

Published: Oct. 21, 2024

The global urge to adopt sustainable chemistry has resulted in the development of more environmentally benign strategies (EBS) that use CO2 and CO2-derived chemicals a step-economic manner. In this context, we investigated dual C–H methylation (C═O)-methoxylation indole derivatives using dimethyl carbonate (DMC) presence catalytic amounts Cs2CO3. Mechanistic insights include DMF-assisted, DMC-induced cooperative ionic catalysis, which allows DMC act as both nucleophilic an electrophilic precursor, resulting N-benzylindolyl ketones.

Language: Английский

MnFe2O4 Nanoparticles‐Catalyzed C3‐Alkylation of Indoles with Benzyl Alcohols under Solvent‐Free Conditions DOI Creative Commons
Ha V. Le, Huy X. Le, Vy T. Nguyen

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(33)

Published: Aug. 28, 2024

Abstract Herein, we present an efficient, one‐pot reaction for accessing 3‐benzylated indoles via the coupling of benzyl alcohols with under heterogeneous catalysis by manganese ferrite (MnFe 2 O 4 ) nanoparticles. Notably, this reaction, first time, employs MnFe nanoparticles prepared using a simple grinding method. The high compatibility enables broad substrate scope and regioselectivity. Moreover, approach offers several attractive highlights including use recyclable oxide catalyst green cost‐effective alkylating reagents solvent‐free conditions.

Language: Английский

Citations

2
Synthesis and Biological Analysis of Iso-dimethyltryptamines in a Model of Light-Induced Retinal Degeneration DOI Creative Commons
Ethan J. Pazur, Anna Kalatanova, Nikhil R. Tasker

et al.

ACS Medicinal Chemistry Letters, Journal Year: 2024, Volume and Issue: 15(7), P. 1049 - 1056

Published: June 13, 2024

Iso-dimethyltryptamine (isoDMT) analogues with heterocyclic substitutions at the indole C(3) were prepared in a hydrogen autotransfer alkylation and tested combination natural unnatural clavine alkaloids model of light-induced retinal degeneration for protection against degeneration. On basis measurements optical coherence tomography electroretinography, three compounds showed better efficacy than positive control bromocriptine equivalent systemically administered doses. These studies provide further insights into role serotonin receptors their potential therapeutic applications ocular diseases.

Language: Английский

Citations

1
Five-membered ring systems: Pyrroles and benzo analogs DOI
Chuan Shan, Justin M. Lopchuk

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 123 - 173

Published: Jan. 1, 2024

Language: Английский

Citations

0
Substrate-Induced Cooperative Ionic Catalysis: Difunctionalization of Indole Derivatives Employing Dimethyl Carbonate DOI
Sangita Dattatray Shinde,

Asma Poudel Chhetri,

Sayak Ghosh

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(21), P. 15995 - 16003

Published: Oct. 21, 2024

The global urge to adopt sustainable chemistry has resulted in the development of more environmentally benign strategies (EBS) that use CO2 and CO2-derived chemicals a step-economic manner. In this context, we investigated dual C–H methylation (C═O)-methoxylation indole derivatives using dimethyl carbonate (DMC) presence catalytic amounts Cs2CO3. Mechanistic insights include DMF-assisted, DMC-induced cooperative ionic catalysis, which allows DMC act as both nucleophilic an electrophilic precursor, resulting N-benzylindolyl ketones.

Language: Английский

Citations

0