Oxidative [4+2] Annulation of Pyrrole‐2‐carbaldehyde Derivatives with o‐Hydroxyphenyl Propargylamines: Syntheses of 5,6,7‐Trisubstituted Indolizines
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(63)
Опубликована: Авг. 23, 2024
Abstract
A
base
promoted
oxidative
[4+2]
annulation
of
pyrrole‐2‐carbaldehyde
derivatives
with
o
‐hydroxyphenyl
propargylamines
for
the
synthesis
highly
substituted
indolizines
has
been
developed.
Using
DBN
as
base,
a
broad
range
5,6,7‐trisubstituted
have
prepared
in
good
to
excellent
yields
under
mild
conditions,
and
many
useful
functional
groups
can
be
tolerated.
Язык: Английский
Copper-Catalyzed Three-Component Tandem Cyclization for One-Pot Synthesis of Indole-Benzofuran Bis-Heterocycles
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 22, 2024
A
one-pot,
three-component
synthesis
of
indole-benzofuran
bis-heterocycles
from
terminal
alkynes,
salicylaldehydes,
and
indoles
has
been
developed
via
copper-catalyzed
tandem
annulation.
This
catalytic
system
utilizes
readily
available
starting
materials,
enabling
predictable
with
broad
substrate
versatility,
excellent
regiocontrol,
gram-scale
amenability.
The
reaction
proceeds
a
sequential
pathway
involving
A3
coupling,
1,4-conjugate
addition,
5-exo-dig
cyclization.
Язык: Английский