Oxidative [4+2] Annulation of Pyrrole‐2‐carbaldehyde Derivatives with o‐Hydroxyphenyl Propargylamines: Syntheses of 5,6,7‐Trisubstituted Indolizines

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(63)

Published: Aug. 23, 2024

Abstract A base promoted oxidative [4+2] annulation of pyrrole‐2‐carbaldehyde derivatives with o ‐hydroxyphenyl propargylamines for the synthesis highly substituted indolizines has been developed. Using DBN as base, a broad range 5,6,7‐trisubstituted have prepared in good to excellent yields under mild conditions, and many useful functional groups can be tolerated.

Language: Английский

Copper-Catalyzed Three-Component Tandem Cyclization for One-Pot Synthesis of Indole-Benzofuran Bis-Heterocycles

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

A one-pot, three-component synthesis of indole-benzofuran bis-heterocycles from terminal alkynes, salicylaldehydes, and indoles has been developed via copper-catalyzed tandem annulation. This catalytic system utilizes readily available starting materials, enabling predictable with broad substrate versatility, excellent regiocontrol, gram-scale amenability. The reaction proceeds a sequential pathway involving A3 coupling, 1,4-conjugate addition, 5-exo-dig cyclization.

Language: Английский