Photoredox/NHC cooperative catalysis for alkylacylation of styrenes: An alternative method for the synthesis of γ-aminoketones
Ke-Yang Yu,
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Fu Cheng,
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Dong-Sen Duan
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et al.
Tetrahedron Letters,
Journal Year:
2025,
Volume and Issue:
156, P. 155450 - 155450
Published: Jan. 8, 2025
Language: Английский
Cu(ii)-catalyzed synthesis of N-sulfonated quinolin-2(1H)-one-3-carboxamides
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Herein,
we
present
an
efficient
Cu(
ii
)-catalyzed
cascade
synthesis
of
sulfonated
3-carboxamide
quinolin-2-(1
H
)-ones.
Inthis
paper,
sulfonylhydrazides
underwent
unusual
N–N
bond
cleavage
and
functioned
as
sulfamide
synthons.
Language: Английский
Carbonylative Cyclization of Biaryl Enones with Aldehydes and Oxamic Acids
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(24), P. 4901 - 4911
Published: Jan. 1, 2024
An
oxidative
radical-promoted
carbonylative
cyclization
strategy
for
the
synthesis
of
phenanthren-9-(10
Language: Английский
Metal-Free Synthesis of Pharmaceutically Relevant Sulfonylureas via Direct Reaction of Sulfonamides with Amides
Sahil Mondal,
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Rakhi Sati,
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Muhammed F. Hashim
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et al.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(18), P. 13179 - 13191
Published: Aug. 28, 2024
A
metal-free
process
has
been
developed
for
the
sustainable
synthesis
of
medicinally
important
sulfonylureas
in
one
pot
via
direct
reaction
sulfonamides
with
amides
green
solvent
(DMC).
The
proceeded
efficiently
at
room
temperature,
and
products
were
obtained
good
to
excellent
yields.
use
readily
accessible,
inexpensive,
environmentally
benign
starting
materials
reagents,
mild
conditions,
wide
substrate
scope,
tolerance
air
moisture,
operational
simplicity,
atom
economy
are
salient
features
this
protocol.
Gram-scale
antidiabetic
drugs
tolbutamide
chlorpropamide
yields
further
revealed
practical
utility
procedure.
Additionally,
synthetic
value
straightforward
method
is
showcased
by
late-stage
modification
drug
molecules,
including
drug-drug
conjugation
Preliminary
mechanistic
studies
indicated
Language: Английский
Synthesis of succinyldiamides containing all-quaternary carbon center by photo-induced amidation/smiles rearrangement of alkenes
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
A
novel,
mild,
and
environmentally
friendly
method
was
developed
for
the
synthesis
of
quaternary-carbon-containing
succinyldiamides.
This
found
to
be
compatible
with
many
substrates.
Language: Английский
One-Pot Sequential Synthesis of Alkenylated Dihydroquinolinones and Hexahydroacridinones in Deep Eutectic Solvent Medium
ACS Omega,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 16, 2024
The
sequential
synthesis
of
N-heterocycles
from
saturated
ketones
poses
significant
challenges
and
has
rarely
been
reported.
Herein,
an
efficient
alkenylated
dihydroquinolinones
7
hexahydroacridinones
8
is
achieved
1
or
2
via
dehydrogenation,
cyclization,
oxidation,
α-alkenylation
in
choline
chloride-based
deep
eutectic
solvent
(DES)
medium.
This
strategy
provides
excellent
yield
low-cost,
readily
available
starting
materials
under
environmentally
benign
conditions.
Furthermore,
the
synthesized
compounds
(4,
5,
7,
8)
were
investigated
for
their
photophysical
properties
through
absorption
emission
spectral
studies.
Language: Английский