Pseudo‐Multicomponent Reactions of Lawsone: Synthetic Strategies of Bis‐Lawsone

ChemistrySelect, Год журнала: 2025, Номер 10(1)

Опубликована: Янв. 1, 2025

Abstract 1,4‐Naphthoquinones (1,4‐NQs) are an important class of molecules with diverse pharmaceutical applications. Lawsone, a naturally occurring molecule range bioactivities, falls in the 1,4‐NQs. It possesses 1,3‐dicarbonyl functionality, which has been utilized synthesis bis‐lawsones reaction aldehydes. In this review we have discussed notable developments bis‐lawsone from 2009 to 2023. Also, highlights limitations and future perspectives area.

Язык: Английский

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Recent advances in iodine–DMSO mediated C(sp³)–H functionalization of methyl-azaarenes via Kornblum oxidation

New Journal of Chemistry, Год журнала: 2024, Номер 48(17), С. 7614 - 7638

Опубликована: Янв. 1, 2024

In the iodine–DMSO medium, methyl group of azaarenes is converted into aldehyde via Kornblum oxidation and trapped in situ by nucleophiles to create azaarene-linked functionalized scaffolds.

Язык: Английский

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Arylglyoxal-based multicomponent synthesis of C-3 functionalized imidazoheterocycles

Chemical Papers, Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

Язык: Английский

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One-Pot Multicomponent Synthesis of Fully Substituted 1,3-Thiazoles Appended with Naturally Occurring Lawsone

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Lawsone is a popular bioactive natural product. 1,3-Thiazoles are also widely distributed in many products, FDA-approved drugs, and functional materials. We report herein the first synthesis of naturally occurring lawsone-linked fully substituted 1,3-thiazoles one-pot multicomponent reaction (MCR) arylglyoxals, lawsone, thiobenzamides acetic acid at 90 °C, affording lawsone-1,3-thiazole hybrids excellent yields short times. The advantages present method include facile, robust, easy access to medicinally relevant diverse array hybrids, isolation product by filtration, thereby avoiding column-chromatographic purifications, time, metal- catalyst-free gram-scale synthesis.

Язык: Английский

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C3-Heteroarylation of Indoles via Cu(II)-Catalyzed Aminocupration and Subsequent Nucleophilic Addition of o-Alkynylanilines

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 23, 2025

Transition-metal-catalyzed aminometalation of o-alkynylanilines is a promising pathway for the synthesis C3-functionalized indoles. Herein, we describe Cu(II)-catalyzed site-selective C3-heteroarylation indoles from and quinoline N-oxides. A plausible reaction mechanism involving aminocupration followed by nucleophilic addition Cu(II)-indolyl complexes to N-oxides was proposed. Post-transformations generated C3-heteroarylated demonstrated broad applicability developed method.

Язык: Английский

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Acylsilanes as Weakly Coordinating Directing Groups for Metal-Catalyzed C–H Functionalization

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 6881 - 6894

Опубликована: Апрель 14, 2025

Язык: Английский

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Recyclable LaF₃·Pd nanocatalyst in Suzuki coupling: green synthesis of biaryls from haloarenes and phenylboronic acids

RSC Advances, Год журнала: 2024, Номер 14(30), С. 21269 - 21276

Опубликована: Янв. 1, 2024

A green and sustainable approach has been developed using a recyclable reusable LaF 3 ·Pd nanocatalyst. This catalyst applied in the synthesis of biaryls good to excellent yields via Suzuki coupling aqueous medium.

Язык: Английский

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Ru(II)-Catalyzed C–H Activation/[4+2] Annulation of Sulfoxonium Ylide with Maleimide: Access to Fused Benzo[e]isoindole-1,3,5-trione

Organic Letters, Год журнала: 2024, Номер 26(32), С. 6830 - 6834

Опубликована: Авг. 5, 2024

A ruthenium-catalyzed C-H activation and a concomitant [4+2] annulation of sulfoxonium ylide with maleimide have been demonstrated. This tandem reaction results in the formation fused benzo[

Язык: Английский

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Synthetic Routes to Access Dicarbonylated Aryls and Heteroaryls

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

The regioselective 1,2-dicarbonylation of aryls and heteroaryls offers access to functionalized dicarbonylated heteroaryls, which opens pharmaceuticals bioactive molecules with diverse synthetic utility.

Язык: Английский

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Catalytic Enantioselective Functionalization of Maleimides: An Update

Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(24), С. 3605 - 3622

Опубликована: Ноя. 13, 2024

Comprehensive Summary Maleimide derivatives are well‐established reactive intermediates also found in natural products, synthetic pharmaceuticals and functional polymers. Their specific reactivity widespread applications the field of bioconjugation allowed for development highly selective functionalizations based on simple additions cycloadditions with possible control central C–N axial chirality. These multisite‐reactive scaffolds have aroused a long‐standing interest throughout scientific community more particularly as powerful electrophilic partners recently nucleophilic some transformations. The persistent these easily accessible platforms over last decade has enabled new enantioselective transformations major advancements this presented review. Key Scientists

Язык: Английский

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