Current Research in Biotechnology,
Год журнала:
2024,
Номер
7, С. 100205 - 100205
Опубликована: Янв. 1, 2024
Nanozymes
are
a
class
of
nanoparticles
that
can
mimic
enzyme
activity
and
be
used
for
various
applications
in
modern
clinical
therapy.
It
has
recently
been
observed
nanozymes
have
multi-enzyme
mimicking
activities,
highly
stable,
versatile
easily
modified.
Moreover,
they
high
catalytic
efficiency,
recovery
rates,
improved
substrate
specificity
suitable
mass
production.
The
mechanisms
mainly
include
catalase,
peroxidase,
oxidase,
hydrolase
superoxide
dismutase-like
which
enable
to
as
potential
therapeutics
against
plethora
infectious
lifestyle
disorders.
cancer,
inflammatory
diseases,
neurodegenerative
neurological
disorders,
bacterial,
fungal
viral
infections,
wounds
diseases
associated
with
Reactive
Oxygen
Species.
purpose
writing
this
review
is
provide
comprehensive
compilation
novel
research
work
taken
place
the
last
few
years
regarding
use
We
compiled
kinds
elaborated
on
their
anti-tumorigenic,
antioxidant,
anti-inflammatory,
antibacterial,
antifungal,
antiviral,
neuroprotective
roles.
Their
modes
action
enzymatic
targets
also
discussed.
types
synthesis
summarized,
along
interactions
nanozymes.
Furthermore,
strategies
enhance
compatibility
between
analyzed.
Major
focus
laid
therapeutic
challenges
future
perspectives
using
therapy
debated
later
sections.
Journal of Nanotheranostics,
Год журнала:
2025,
Номер
6(1), С. 4 - 4
Опубликована: Янв. 31, 2025
Regrettably,
despite
undeniable
advances
in
cancer
diagnosis
and
therapy,
primary
brain
(or
cancer)
remains
one
of
the
deadliest
forms
malignant
tumors,
where
glioblastoma
(GBM)
is
known
as
most
diffuse
glioma
astrocytic
lineage.
Fortunately,
to
improve
this
scenario,
remarkable
progress
nanotechnology
has
brought
new
promise
raised
expectations
treatment.
Nanomedicine,
principally
an
area
amalgamating
with
biology
medicine,
demonstrated
a
pivotal
role,
starting
earliest
detection
while
also
offering
novel
multimodal
therapy
alternatives.
In
vast
realm
nanotechnology,
nanozymes,
type
nanomaterial
intrinsic
enzyme-like
activities
characteristics
connecting
fields
nanocatalysts,
enzymology,
biology,
have
emerged
powerful
nanotools
for
theranostics.
Hence,
fascinating
field
research
experienced
exponential
growth
recent
years.
As
it
virtually
impossible
cover
all
literature
on
broad
domain
science
paper,
review
focuses
presenting
multidisciplinary
approach,
its
content
extending
from
fundamental
knowledge
nanozymes
enzyme-mimicking
catalysis
targeting
cancers.
Although
we
are
at
very
early
stages
research,
can
be
envisioned
that
strategic
development
theranostics
will
positively
offer
disruptive
nanoplatforms
future
nano-oncology.
This
review
highlights
iron-based
nanozymes
including
iron
oxides,
single-atom
nanozymes,
and
MOFs
that
induce
ferroptosis
via
ROS
generation
Fenton
chemistry,
achieved
by
POD-,
CAT-,
OXD-
SOD-like
activities.
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 23, 2024
The
nanozymes
(NZs)
are
the
artificial
catalyst
deployed
for
biosensing
with
their
uniqueness
(high
robustness,
surface
tenability,
inexpensive,
and
stability)
obtaining
a
better
response/miniaturization
of
varied
sensors
than
traditional
ancestors.
Nowadays,
nanomaterials
broadened
scale
such
as
metal-organic
frameworks
(MOFs),
metals/metal
oxides
widely
engaged
in
generating
NZ-based
biosensors
(BS).
Diverse
strategies
like
fluorescent,
colorimetric,
surface-enhanced
Raman
scattering
(SERS),
electrochemical
sensing
principles
were
implemented
signal
transduction
NZs.
Despite
broad
advantages,
numerous
encounters
(like
specificity,
feasibility,
stability,
issues
scale-up)
affecting
potentialities
NZs-based
BS,
thus
need
prior
attention
promising
exploration
revolutionary
outcome
advanced
theranostics.
This
review
includes
different
types
NZs,
progress
NZs
tailored
bio-sensing
techniques
detecting
abundant
bio
analytes
theranostic
purposes.
Further,
discussion
highlighted
some
recent
challenges
along
progressive
way
possibly
overcoming
followed
by
commercial
outbreaks.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 11, 2024
Abstract
Acute
kidney
injury
(AKI)
is
a
critical
condition
with
wide
range
of
triggers
that
cause
heavy
burden
on
public
health.
Despite
its
high
incidence
and
mortality,
the
treatment
AKI
still
highly
relies
hemodialysis,
which
costly
usually
accompanied
by
severe
complications.
Therefore,
development
new
therapeutic
targets
methods
for
urgently
needed.
Herein,
ferroptosis‐targeting
strategy
rationally
designed
ferroptosis‐inhibitive
polypeptide‐based
polymersomes
(polypeptosomes,
FIPs)
proposed.
Such
FIPs
are
self‐assembled
from
poly(glutamic
acid)‐
block
‐poly(methionine‐
stat
‐tyrosine)
[PGA
9
‐
b
‐P(Met
8
‐PTyr
13
)].
The
ferroptosis‐inhibition
function
arises
rationally‐selected
amino
acid
composition:
P(Met‐
‐Tyr)
endows
scavenging
efficiency
over
90%
toward
different
reactive
oxygen
species
(ROS);
while
glutamate
tyrosine
residues,
as
well
amide
groups,
can
bind
iron
ions,
thus
blocking
overload
lipid
peroxide
in
cells.
In
vivo
experiments
confirm
effectively
alleviate
oxidative
stress,
inhibit
ferroptosis,
restore
functions.
Transcriptome
sequencing
further
reveals
mechanisms
FIPs.
Overall,
such
polypeptosomes
capable
multiple
pathways
ferroptosis
open
avenue
provide
fresh
insights
into
generalized
therapies
inflammation.
