Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
The photoredox eosin Y-catalyzed difunctionalization of alkenes with quinoxalinones and dialkyl dithiophosphoric acids was realized. This reaction exhibited excellent functional group compatibility.
Язык: Английский
Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(12), С. 2758 - 2763
Опубликована: Апрель 24, 2024
Abstract Herein, we present a (NH 4 ) 2 S O 8 mediated difunctionalization reaction of aryl alkenes with quinoxalinones and P(O)SH compounds. This method enables the synthesis various phosphorothioate‐containing quinoxalin‐2(1 H )‐one derivatives (46 examples) in 37–79% yields. The is compatible range functional groups easily adaptable to large‐scale synthesis. Preliminary studies suggest involvement phosphorothioate radicals these transformations.
Язык: Английский
Процитировано
10
ChemistrySelect, Год журнала: 2025, Номер 10(12)
Опубликована: Март 1, 2025
Abstract In light of the extensive application fluoroalkyl‐containing molecules and functionalized quinoxalin‐2(1 H )‐ones in medicinal chemistry functional materials, visible‐light‐enabled C3‐H fluoroalkylation has garnered significant attention. this review, we provide a detailed overview latest advancements rapidly evolving research area. We cover utilization various fluoroalkyl sources under conditions photocatalyst or without photocatalyst, discuss pertinent reaction conditions, mechanisms, substrate scope. Our objective is to help more chemists comprehend challenges opportunities within field, thereby fostering its development.
Язык: Английский
Процитировано
0
Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Recent advances in the photo-promoted C3–H alkylation reaction of quinoxalin-2(1 H )-ones with different agents.
Язык: Английский
Процитировано
0
Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111402 - 111402
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
ChemistrySelect, Год журнала: 2025, Номер 10(21)
Опубликована: Июнь 1, 2025
Abstract Given the significant applications of quinoxalinones in medicinal, pharmaceutical, and organic chemistry, developing an efficient synthetic approach for their facile assembly has received substantial attention chemistry. Conversely, it been established that incorporating fluorine into molecules either alters or enhances physical, chemical, biological properties target molecules. In this context, synergic combination medicinal associated with quinoxaline‐2(1 H )‐ones, wide chemical landscape fluorine‐containing compounds, installing atom as a single di/tri‐substituted groups on C‐3 position quinoxalin‐2(1 )‐one under visible light irradiation is increasing academic scientific interests. mini‐review article, we covered recent progress achieved various light‐induced direct functionalization )‐ones accessing diverse C3‐substituted embedded mono/di/tri‐substituted fluorine. Despite discussing advantages, shortcomings, challenges reaction discovery, mechanistic rationalizations are also underscored.
Язык: Английский
Процитировано
0
European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(27)
Опубликована: Май 23, 2024
Abstract We herein disclose a direct and practical photocatalytic three‐component α‐trifluoroalkyl‐β‐heteroarylation of various unactivated alkenes with trifluoroacetates quinoxalin‐2(1 H )‐ones. The reaction takes place via photoinduced LMCT process, allowing efficient synthesis variety 3‐fluoroalkylated )‐one derivatives in moderate to excellent yields under mild conditions.
Язык: Английский
Процитировано
1
Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
The photoredox eosin Y-catalyzed difunctionalization of alkenes with quinoxalinones and dialkyl dithiophosphoric acids was realized. This reaction exhibited excellent functional group compatibility.
Язык: Английский
Процитировано
0