Hydrogels for Wound Dressings: Applications in Burn Treatment and Chronic Wound Care
Journal of Composites Science,
Год журнала:
2025,
Номер
9(3), С. 133 - 133
Опубликована: Март 13, 2025
Severe
skin
injuries
such
as
burns
and
chronic
wounds
are
a
subject
of
interest
in
the
medical
field,
they
require
much
attention.
These
types
susceptible
to
serious
complications,
which
can
worsen
health
patients
reduce
their
quality
life.
Hydrogels
have
emerged
innovative
wound
dressings
for
treating
acute
wounds,
including
burns,
diabetic
foot
ulcers,
venous
leg
pressure
ulcers.
polymeric
networks
provide
moist
environment,
promote
cellular
migration,
offer
antimicrobial
properties,
being
recognized
superior
conventional
dressings.
This
review
aims
explore
recent
advancements
hydrogel-based
dressings,
emphasizing
state-of-the-art
technologies
used
this
purpose
trend
achieving
personalized
therapeutic
approaches.
Despite
promising
vitro
vivo
findings
described
review,
further
clinical
validation
large-scale
manufacturing
optimizations
required
widespread
adoption.
Язык: Английский
Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing
Aggregate,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
Abstract
Diabetes
significantly
impairs
the
body's
wound‐healing
capabilities,
leading
to
chronic,
infection‐prone
wounds.
These
wounds
are
characterized
by
hyperglycemia,
inflammation,
hypoxia,
variable
pH
levels,
increased
matrix
metalloproteinase
activity,
oxidative
stress,
and
bacterial
colonization.
complex
conditions
complicate
effective
wound
management,
prompting
development
of
advanced
diabetic
care
strategies
that
exploit
specific
characteristics
such
as
acidic
pH,
high
glucose
stress
trigger
controlled
drug
release,
thereby
enhancing
therapeutic
effects
dressings.
Among
solutions,
hydrogels
emerge
promising
due
their
stimuli‐responsive
nature,
making
them
highly
for
managing
these
The
latest
advancements
in
mono/multi‐stimuli‐responsive
smart
showcase
superiority
potential
healthcare
materials,
highlighted
relevant
case
studies.
However,
traditional
dressings
fall
short
meeting
nuanced
needs
wounds,
adjustable
adhesion,
easy
removal,
real‐time
status
monitoring,
dynamic
release
adjustment
according
wound's
conditions.
Responsive
represent
a
significant
leap
forward
proficient
sensing
responding
environment,
offering
more
targeted
approach
treatment.
This
review
highlights
recent
dressing,
delivery,
emphasizing
role
improving
healing.
It
addresses
ongoing
challenges
future
directions,
aiming
guide
clinical
adoption.
Язык: Английский
Polydopamine Nanoparticle-Loaded Antifreezing and Photothermal Organohydrogel Based on Pullulan for Frostbite Therapy
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Rapid
rewarming
is
the
standard
and
most
common
strategy
for
treating
frostbite.
Due
to
freezing
susceptibility
lack
of
thermal
effects,
traditional
therapeutic
hydrogels
are
not
suitable
being
directly
applied
frostbite
therapy
in
cold
conditions.
Contrastively,
antifreezing
photothermal
that
apt
freeze
capable
wounds
deemed
hold
great
application
potential
such
therapy.
Nevertheless,
these
have
rarely
been
researched.
Herein,
using
glycerol
as
cryoprotectant
polydopamine
nanoparticles
(PDA
NPs)
agent,
a
novel
pullulan-based
organohydrogel
(CPG-PDA
organohydrogel)
was
successfully
developed
treat
first
time.
The
CPG-PDA
formed
through
1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide
hydrochloride
(EDC·HCl)-mediated
esterification
reactions
found
possess
certain
mechanical
stability,
shear-thinning
behaviors
(injectability),
excellent
properties,
superb
vitro
vivo
performances,
outstanding
cytocompatibility
hemocompatibility.
Most
noticeably,
coating
observed
significantly
accelerate
healing
rats.
opined
be
promising
platform
direct
treatment
environment
would
open
new
avenue
design
strategies
Язык: Английский
A polydopamine coated magnetic spiral switchable composite material for photothermal sterilization and dual-color fluorescence detection of food-borne pathogens
Sensors and Actuators B Chemical,
Год журнала:
2024,
Номер
425, С. 136935 - 136935
Опубликована: Ноя. 17, 2024
Язык: Английский
The Effects of Synthetic Polymers on the Release Patterns of Bupivacaine Hydrochloride from Sodium Hyaluronate Hydrogels
Biomedicines,
Год журнала:
2024,
Номер
13(1), С. 39 - 39
Опубликована: Дек. 27, 2024
Using
hydrogels
for
the
controlled
release
of
drugs
is
beneficial
patients,
who
then
receive
proper
dose
medicinal
substance.
In
addition,
formulation
can
provide
more
consistent
drug
absorption
while
reducing
frequency
dosing.
The
aim
this
investigation
to
propose
a
novel
HA
(sodium
hyaluronate)-based
hydrogel
intra-articular
injection
doped
with
synthetic
polymers
and
incorporated
bupivacaine
hydrochloride
(Bu)
as
local
anesthetic.
other
study
reveal
effects
formulation's
ingredients
on
its
viscosity
relationship
between
hydrogel's
release.
First,
HA-based
Bu
were
prepared.
A
hydrogels'
viscosities
was
performed
using
rotational
viscometer.
Release
tests
carried
out
by
employing
paddle-over-disk
apparatus
following
USP/Ph.Eur
guidelines.
concentrations
in
acceptor
fluid
analyzed
spectrophotometrically.
It
found
that
higher
than
made
only
HA.
AX
(ammonium
acryloyldimethyltaurate/VP
copolymer)
highest,
measuring
6750
±
160
cP
12623
379
without
Bu,
respectively.
results
kinetic
experiment
indicate
Higuchi
Korsmeyer-Peppas
models
best
described
released
most
slowly
from
AX.
rate
constants
obtained
kH
=
4.4
0.2
mg
×
min-1/2
kK-P
3.4
10-2
min-N,
half-release
time,
calculated
model,
longest
AX,
at
199.5
17.6
min.
This
indicates
incorporation
into
may
prolong
dissolution.
optimal
Bu.
Язык: Английский