Cell investigation., Год журнала: 2024, Номер unknown, С. 100003 - 100003
Опубликована: Ноя. 1, 2024
Язык: Английский
Materials Horizons, Год журнала: 2024, Номер 11(13), С. 3082 - 3089
Опубликована: Янв. 1, 2024
Polycatechols modulate amyloid-associated toxicities, arrest labile iron, inhibit lipid peroxidation, and regulate tau liquid–liquid phase separation (LLPS) to mitigate the pathological nexus between ferroptosis AD.
Язык: Английский
Процитировано
9
Neural Regeneration Research, Год журнала: 2024, Номер 20(3), С. 613 - 631
Опубликована: Март 1, 2024
Alzheimer’s disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, cure for has not yet been found. Oxidative stress mediates excessive oxidative responses, its involvement in pathogenesis as primary or secondary pathological event widely accepted. As member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With discovery ferroptosis, central role anti-lipid peroxidation several diseases, including disease, received widespread attention. Increasing evidence suggests that expression inhibited brain, resulting stress, inflammation, apoptosis, which are closely associated damage disease. Several therapeutic approaches, such small molecule drugs, natural plant products, non-pharmacological treatments, ameliorate cognitive function by promoting enhancing activity. Therefore, upregulation may be promising strategy treatment This review provides overview gene structure, biological functions, regulatory mechanisms 4, discussion on important events related summary advances small-molecule therapies targeting Most prior studies this subject used animal models, relevant clinical lacking. Future trials required validate effects strategies
Язык: Английский
Процитировано
9
Phytomedicine, Год журнала: 2025, Номер 139, С. 156472 - 156472
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
1
Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 22, 2025
Alzheimer's disease (AD) is a chronic neurodegenerative of the central nervous system caused by loss neuronal or myelin function, accompanied ferroptosis. Astragalus membranaceus (Fisch.) Bge. (A. membranaceus) one China's homologous lists medicines and food, its active component saponins have neuroprotective effects. This study examines mechanism from A. (AS) in treating AD. UPLC-Q-TOF-MS analyzed composition AS. Ferroptosis models were established to evaluate anti-AD efficacy. As result, AS treatment inhibited ferroptosis SAMP8 mice restoring iron homeostasis lipid peroxidation (LPO) balance brain, thereby improving cognitive impairment pathological damage. Mechanistically, reduced Fe2+, MDA, ROS levels enhanced protein SLC7A11, GPX4, FTH1, FPN1. NADPH oxidase 4 (NOX4) overexpression revealed that NOX4, reducing NOX4 stability regulating NOX4/Nrf2 pathway erastin-injured HT22 cells significantly alleviating Therefore, improved AD rebuilding LPO brain. has potential be promising candidate medicine for
Язык: Английский
Процитировано
1
Journal of Ethnopharmacology, Год журнала: 2024, Номер 326, С. 117937 - 117937
Опубликована: Фев. 27, 2024
Язык: Английский
Процитировано
6
Chemical Communications, Год журнала: 2024, Номер 60(32), С. 4334 - 4337
Опубликована: Янв. 1, 2024
Polyphenols, notably gallic acid (GA), act as a biphasic modulator of tau liquid–liquid phase separation in concentration-dependent manner. GA accelerates the sol-to-gel transition and inhibits aggregate-associated toxicity.
Язык: Английский
Процитировано
6
Current Cancer Drug Targets, Год журнала: 2024, Номер 24(10), С. 1047 - 1060
Опубликована: Фев. 1, 2024
Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers with poor prognosis in head and neck. Elucidating molecular mechanisms underlying OSCC occurrence development important for therapy. Dysregulated palmitoylation-related enzymes have been reported several but OSCC.
Язык: Английский
Процитировано
5
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 275, С. 133578 - 133578
Опубликована: Июль 1, 2024
Язык: Английский
Процитировано
3
Molecular Neurobiology, Год журнала: 2024, Номер unknown
Опубликована: Июль 16, 2024
Язык: Английский
Процитировано
3
Journal of Pineal Research, Год журнала: 2024, Номер 76(6)
Опубликована: Сен. 1, 2024
ABSTRACT Recent evidence indicates that the damaged regions in osteoarthritis are accompanied by accumulation of iron ions. Ferroptosis, as an iron‐dependent form cell death, holds significant implications osteoarthritis. Melatonin, a natural product with strong scavenging abilities against reactive oxygen species and lipid peroxidation, plays crucial role treatment This study aims to demonstrate existence ferroptosis explore specific mechanism melatonin suppressing alleviating Our findings reveal reverses inflammation‐induced oxidative stress peroxidation while promoting expression extracellular matrix components chondrocytes, safeguarding cells. research has revealed NADPH oxidase 4 (NOX4) serves molecule process Specifically, NOX4 is located on mitochondria which can induce disorders mitochondrial energy metabolism dysfunction, thereby intensifying peroxidation. LC‐MS analysis further uncovered GRP78 downstream binding protein NOX4. induces weakening GRP78's protective effect GPX4 reducing its expression. Melatonin inhibit upregulation mitigate effectively suggests therapy represents promising new approach for
Язык: Английский
Процитировано
3