Cell investigation., Год журнала: 2024, Номер unknown, С. 100003 - 100003
Опубликована: Ноя. 1, 2024
Язык: Английский
Food & Function, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Ginger leaf polyphenols (GLP) alleviated β-amyloid toxicity by activating the JNK/FOXO signaling pathway in Caenorhabditis elegans .
Язык: Английский
Процитировано
1
Phytomedicine, Год журнала: 2025, Номер 139, С. 156472 - 156472
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
1
ACS Chemical Neuroscience, Год журнала: 2025, Номер unknown
Опубликована: Март 9, 2025
Alzheimer's disease (AD), which is caused by the accumulation of amyloid-beta, a major medical concern today. Controlling these aggregates critical to drug development, but delivering them effectively into bloodstream poses significant challenges. In this context, aromatherapy has been proposed as an innovative and promising approach for AD disease. The volatile compounds cinnamaldehyde, phenylethyl alcohol, α-asarone, β-caryophyllene have neuroprotective effects that can be effective in treatment neurodegenerative diseases like AD. amyloid-beta (Aβ) fragment (25–35), retains properties full-length Aβ used suitable model evaluate potential toxicity associated with This study investigated four mentioned at different concentrations on fibrillation process (25–35) peptide. Structural changes peptide analyzed using various techniques such fluorescence probing, far-UV circular dichroism spectroscopy (CD), atomic force microscopy (AFM). Fluorescence probing results showed prevent formation amyloid fibrils forming chemical bonds intermediate species. CD indicated decrease β-sheet content confirmed effect pH structural changes. AFM analysis revealed prevented changed average size intermediates oligomeric These findings show future patients emphasize importance natural prevention diseases.
Язык: Английский
Процитировано
1
Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 22, 2025
Alzheimer's disease (AD) is a chronic neurodegenerative of the central nervous system caused by loss neuronal or myelin function, accompanied ferroptosis. Astragalus membranaceus (Fisch.) Bge. (A. membranaceus) one China's homologous lists medicines and food, its active component saponins have neuroprotective effects. This study examines mechanism from A. (AS) in treating AD. UPLC-Q-TOF-MS analyzed composition AS. Ferroptosis models were established to evaluate anti-AD efficacy. As result, AS treatment inhibited ferroptosis SAMP8 mice restoring iron homeostasis lipid peroxidation (LPO) balance brain, thereby improving cognitive impairment pathological damage. Mechanistically, reduced Fe2+, MDA, ROS levels enhanced protein SLC7A11, GPX4, FTH1, FPN1. NADPH oxidase 4 (NOX4) overexpression revealed that NOX4, reducing NOX4 stability regulating NOX4/Nrf2 pathway erastin-injured HT22 cells significantly alleviating Therefore, improved AD rebuilding LPO brain. has potential be promising candidate medicine for
Язык: Английский
Процитировано
1
Journal of Ethnopharmacology, Год журнала: 2024, Номер 326, С. 117937 - 117937
Опубликована: Фев. 27, 2024
Язык: Английский
Процитировано
6
Chemical Communications, Год журнала: 2024, Номер 60(32), С. 4334 - 4337
Опубликована: Янв. 1, 2024
Polyphenols, notably gallic acid (GA), act as a biphasic modulator of tau liquid–liquid phase separation in concentration-dependent manner. GA accelerates the sol-to-gel transition and inhibits aggregate-associated toxicity.
Язык: Английский
Процитировано
6
Current Cancer Drug Targets, Год журнала: 2024, Номер 24(10), С. 1047 - 1060
Опубликована: Фев. 1, 2024
Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers with poor prognosis in head and neck. Elucidating molecular mechanisms underlying OSCC occurrence development important for therapy. Dysregulated palmitoylation-related enzymes have been reported several but OSCC.
Язык: Английский
Процитировано
5
Molecular Neurobiology, Год журнала: 2024, Номер unknown
Опубликована: Июль 16, 2024
Язык: Английский
Процитировано
4
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 275, С. 133578 - 133578
Опубликована: Июль 1, 2024
Язык: Английский
Процитировано
3
Journal of Pineal Research, Год журнала: 2024, Номер 76(6)
Опубликована: Сен. 1, 2024
ABSTRACT Recent evidence indicates that the damaged regions in osteoarthritis are accompanied by accumulation of iron ions. Ferroptosis, as an iron‐dependent form cell death, holds significant implications osteoarthritis. Melatonin, a natural product with strong scavenging abilities against reactive oxygen species and lipid peroxidation, plays crucial role treatment This study aims to demonstrate existence ferroptosis explore specific mechanism melatonin suppressing alleviating Our findings reveal reverses inflammation‐induced oxidative stress peroxidation while promoting expression extracellular matrix components chondrocytes, safeguarding cells. research has revealed NADPH oxidase 4 (NOX4) serves molecule process Specifically, NOX4 is located on mitochondria which can induce disorders mitochondrial energy metabolism dysfunction, thereby intensifying peroxidation. LC‐MS analysis further uncovered GRP78 downstream binding protein NOX4. induces weakening GRP78's protective effect GPX4 reducing its expression. Melatonin inhibit upregulation mitigate effectively suggests therapy represents promising new approach for
Язык: Английский
Процитировано
3