Glutathione‐Driven Disassembly of Planar Organic Phototherapeutic Agents to Enhance Photodynamic‐Photothermal Therapy Performance for Nasopharyngeal Carcinoma

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

The self-assembly of hydrophobic organic phototherapeutic agents (OPTAs) with expansive planar structures into nanoparticles (NPs) represents a pivotal strategy to bolster their biocompatibility. However, the tight molecular packing within these NPs significantly influences generation reactive oxygen species (ROS) and photothermal conversion efficiency (PCE), posing substantial hurdle elevating efficacy photodynamic therapy (PDT) (PTT) for such NPs. In this article, three OPTAs by donor engineering are synthesized. Notably, 4,8-Bis (5-phenylthiophen-2-yl)-6-(2-ethylhexyl)-[1,2,5] thiadiazole [3,4-F] benzotriazole (BTBT), which incorporates benzene ring as donor, exhibits highest ROS optimal capability. To further augment overall phototheranostic potential BTBT NPs, glutathione (GSH)-driven disassembly is employed. This not only alleviates aggregation-caused quenching (ACQ) effect on but also facilitates enhanced free rotation. As result, production sees tenfold increase, temperature rises 8.3 °C, achieving PCE 77.03%. summary, versatile proposed that concurrently enhances performance both PDT PTT in OPTAs, while advancing state-of-the-art nasopharyngeal carcinoma (NPC) treatment.

Язык: Английский

---

Stimuli-responsive nanotheranostic systems conjugated with AIEgens for advanced cancer bio-imaging and treatment

Journal of Controlled Release, Год журнала: 2024, Номер 373, С. 766 - 802

Опубликована: Авг. 3, 2024

Язык: Английский

---

Cancer-targeted and Biomarker-activated Fluorescent Probe for Diagnosis Imaging and Therapy

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137275 - 137275

Опубликована: Янв. 1, 2025

Язык: Английский

---

Molecularly amphiphilic NIR-II AIEgen assemblies: Ultra-small fluorescent dots for tumor-targeted imaging with high signal-to-noise ratio

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111145 - 111145

Опубликована: Март 1, 2025

Язык: Английский

---

Near-Infrared Aggregation-Induced Emission (AIE) Molecules Based on Coupling of Triarylamine-Modified Benzothiadiazole Units

Chinese Journal of Organic Chemistry, Год журнала: 2025, Номер 45(1), С. 205 - 205

Опубликована: Янв. 1, 2025

Язык: Английский

---

Near‐Infrared Multiple‐Resonance Polycyclic Aromatic Hydrocarbon as Type I Photosensitizer Toward High‐Performance Synergistic Phototherapy

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 23, 2025

Abstract Type I photosensitization is of particular significance in the anaerobic tumor treatment. Nonetheless, development high‐performance type photosensitizers (PSs) remains challenging, due to weak absorption and inefficient intersystem crossing (ISC) progress. Herein, an effective approach toward a near‐infrared (NIR) PS ( NIR‐BN ) demonstrated using boron/nitrogen‐embedded polycyclic aromatic hydrocarbon with multiple‐resonance (MR) character, for first time. A small singlet‐triplet splitting (Δ E ST = 0.09 eV) high molar extinction coefficient (3.3 × 10 4 M −1 cm NIR MR‐configured supports efficient ISC triplet sensitization. The distorted molecular configurations induce multi‐model structural relaxations after optical excitation, resulting remarkable photothermal conversion efficiency exceeding 50% nanoparticles. Of note, nanoparticles are capable generating highly toxic superoxide anion radical (O 2 •− under 660 nm laser irradiation, benefiting from vigorous intramolecular dihedral angle vibrations excited states. Consequently, biocompatible demonstrates superior performance vivo synergistic photodynamic therapies.

Язык: Английский

---

NIR-II absorbing aza-BODIPY with the D-A-A’ framework for PTT/PDT co-therapy

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111041 - 111041

Опубликована: Март 1, 2025

Язык: Английский

---

Synthesis of Coumarin-Based Photosensitizers for Enhanced Antibacterial Type I/II Photodynamic Therapy

Molecules, Год журнала: 2024, Номер 29(16), С. 3793 - 3793

Опубликована: Авг. 10, 2024

Photodynamic therapy (PDT) is an effective method for treating microbial infections by leveraging the unique photophysical properties of photosensitizing agents, but issues such as fluorescence quenching and restricted generation reactive oxygen species (ROS) under hypoxic conditions still remain. In this study, we successfully synthesized designed a coumarin-based aggregation-induced emission luminogen (AIEgen), called ICM, that shows remarkable capacity type I ROS II generation. The 1O2 yield ICM 0.839. it produces include hydroxyl radicals (HO•) superoxide anions (O2•−), with highly antibacterial specifically targeting Staphylococcus aureus (a Gram-positive bacterium). Furthermore, enables broad-spectrum imaging exhibits excellent biocompatibility. Consequently, potent photosensitizer eliminating pathogenic microorganisms, represents promising tool in addressing threat posed these pathogens.

Язык: Английский

---

Neutrophil elastase-activated carbon dots for non-invasive early diagnosis of inflammatory bowel disease by near-infrared-II fluorescence imaging

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 156099 - 156099

Опубликована: Сен. 1, 2024

Язык: Английский

---

NIR-induced antimicrobial efficacy of TPA-BOIMPY conjugate through photothermal and photodynamic synergy

Journal of Photochemistry and Photobiology A Chemistry, Год журнала: 2024, Номер 460, С. 116136 - 116136

Опубликована: Ноя. 12, 2024

Язык: Английский

---