A multifunctional ROS cascade nanoplatform enables common prosperity of O2 and H2O2 for magnetic targeting and fluorescence imaging-guided photodynamic/chemodynamic therapy

Chemical Engineering Journal, Год журнала: 2025, Номер 506, С. 160178 - 160178

Опубликована: Янв. 1, 2025

Язык: Английский

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Multifunctional CeO₂/Graphene Nanoribbon Nanozyme for Synergistic Photothermal and Chemodynamic Therapy of Tumor

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Язык: Английский

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Phosphole-Based Fluorescent Biomaterials for Imaging and Therapy

Chemical & Biomedical Imaging, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Язык: Английский

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Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitizers for the Efficient Phototherapy of Hypoxic Tumors

Journal of the American Chemical Society, Год журнала: 2025, Номер 147(9), С. 7360 - 7376

Опубликована: Фев. 15, 2025

Hypoxia, a hallmark of many solid tumors, is linked to increased cancer aggressiveness, metastasis, and resistance conventional therapies, leading poor patient outcomes. This challenges the efficiency photodynamic therapy (PDT), which relies on generation cytotoxic reactive oxygen species (ROS) through irradiation photosensitizer (PS), process partially dependent levels. In this work, we introduce novel family potent PSs based ruthenium(II) polypyridyl complexes with 2,2′-bipyridyl ligands derived from COUPY coumarins, termed COUBPYs. Ru-COUBPY exhibit outstanding in vitro cytotoxicity against CT-26 cells when irradiated light within phototherapeutic window, achieving nanomolar potency both normoxic hypoxic conditions while remaining nontoxic dark, impressive phototoxic indices (>30,000). Their ability generate Type I II ROS underpins their exceptional PDT efficiency. The lead compound study, SCV49, shows favorable vivo pharmacokinetic profile, excellent toxicological tolerability, tumor growth inhibition mice bearing subcutaneous tumors at doses as low 3 mg/kg upon deep-red (660 nm). These results allow us propose SCV49 strong candidate for further preclinical development, particularly treating large tumors.

Язык: Английский

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Intracellular Photocatalytic NADH/NAD(P)H Oxidation for Cancer Drug Development

Journal of the American Chemical Society, Год журнала: 2025, Номер 147(9), С. 7161 - 7181

Опубликована: Фев. 20, 2025

Photocatalytic cancer therapy (PCT) has emerged as a cutting-edge anticancer mechanism of action, harnessing light energy to mediate the catalytic oxidation intracellular substrates. PCT is significant current importance due its potential address limitations conventional chemotherapy, particularly drug resistance and side effects. This approach offers noninvasive, targeted treatment option by utilizing metal-based photocatalysts induce redox metabolic disorders within cells. The disrupt cell metabolism converting NADH/NAD(P)H NAD+/NAD(P)+ via photoredox processes, altering NAD+/NADH or NAD(P)+/NAD(P)H ratios, which are crucial for cellular metabolism. Ir(III), Ru(II), Re(I), Os(II) demonstrated promising efficacy. Despite these developments, gaps remain in literature translating this new into clinical trials. Perspective critically examines developments research area provides future directions designing efficient PCT.

Язык: Английский

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Near‐Infrared Multiple‐Resonance Polycyclic Aromatic Hydrocarbon as Type I Photosensitizer Toward High‐Performance Synergistic Phototherapy

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 23, 2025

Abstract Type I photosensitization is of particular significance in the anaerobic tumor treatment. Nonetheless, development high‐performance type photosensitizers (PSs) remains challenging, due to weak absorption and inefficient intersystem crossing (ISC) progress. Herein, an effective approach toward a near‐infrared (NIR) PS ( NIR‐BN ) demonstrated using boron/nitrogen‐embedded polycyclic aromatic hydrocarbon with multiple‐resonance (MR) character, for first time. A small singlet‐triplet splitting (Δ E ST = 0.09 eV) high molar extinction coefficient (3.3 × 10 4 M −1 cm NIR MR‐configured supports efficient ISC triplet sensitization. The distorted molecular configurations induce multi‐model structural relaxations after optical excitation, resulting remarkable photothermal conversion efficiency exceeding 50% nanoparticles. Of note, nanoparticles are capable generating highly toxic superoxide anion radical (O 2 •− under 660 nm laser irradiation, benefiting from vigorous intramolecular dihedral angle vibrations excited states. Consequently, biocompatible demonstrates superior performance vivo synergistic photodynamic therapies.

Язык: Английский

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Three Decades of Photodynamic Therapy for Glioblastoma: A Comprehensive Scientometric Analysis

Photodiagnosis and Photodynamic Therapy, Год журнала: 2025, Номер unknown, С. 104533 - 104533

Опубликована: Март 1, 2025

Photodynamic therapy (PDT) has emerged as a promising adjunctive treatment for glioblastoma (GBM), yet comprehensive bibliometric analysis of this field is lacking. This study explores research trends, major contributors, and hotspots in PDT GBM to provide an integrated overview its development. Literature from 1993 2024 was retrieved the Web Science Core Collection. Bibliometric tools, including CiteSpace, analyzed publication collaborations, keyword co-occurrence identify influential authors, institutions, journals. A total 799 publications showed growing interest, peaking 2022. The United States China were leading with prominent institutions like University California System Centre National de la Recherche Scientifique. Influential figures, such Jiro Akimoto Walter Stummer, advanced clinical applications fluorescence-guided techniques. Early studies photodynamic have focused on evaluating efficacy potential side effects, transitioning towards innovative strategies targeted drug delivery, nanotechnology, combination therapies. However, similarities between early recent are search safe reliable photosensitizers. Keyword highlighted "5-aminolevulinic acid", "in vitro", "polyethylene glycol compounds" key areas, while timeline revealed shifts foundational photosensitizer approaches addressing tumor heterogeneity resistance. provides systematic GBM, spotlighting breakthroughs collaborative networks. findings emphasize importance preclinical innovation translation fully realize PDT's therapy.

Язык: Английский

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Improved Orthogonality in Naphthalimide/Cyanine Dyad Boosts Superoxide Generation: a Tumor‐Targeted Type‐I Photosensitizer for Photodynamic Therapy of Tumor by Inducing Ferroptosis

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

It is highly desired to achieve Type-I photosensitizer (PS) overcome the hypoxic limitation found in most clinically used PSs. Herein, a new heavy-atom-free PS T-BNCy5 presented by incorporating biotin-modified naphthalimide (NI) unit into meso-position of N-benzyl-functionalized, strongly photon-capturing pentamethine cyanine (Cy5) dye. Such molecular engineering induces rigid orthogonal geometry between NI and Cy5 units introducing an intramolecular sandwich-like π-π stacking assembly, which effectively promotes intersystem crossing (ISC) greatly extends triplet-state lifetime (τ = 389 µs), thereby markedly improving superoxide (O2 •-)-generating ability. In vitro assays reveal that specifically accumulates mitochondria, where it not only generates O2 •- under photoirradiation but also burst cytotoxic hydroxy radical (HO•) cascade biochemical reactions, ultimately triggering cell ferroptosis with IC50 value up ≈0.45 µm whether normoxia or hypoxia. vivo manifest that, benefiting from its biotin unit, displays strong tumor-targeting ability, after single PDT treatment, can ablate tumor almost completely be cleared body through biosafe urinary excretion, indicating potential for future clinical translation.

Язык: Английский

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Enhancing excited-state population of perylenequinone photosensitizer with asymmetric laser pulses

Applied Physics Letters, Год журнала: 2025, Номер 126(10)

Опубликована: Март 1, 2025

Perylenequinones are important photosensitizers commonly used in photodynamic therapy (PDT) due to their efficient photoreactivity and photostability, which originate from excited state intramolecular proton transfer (ESIPT). Herein, the mechanisms of ESIPT explored through first-principle calculations, slowly-turned-on rapidly-turned-off (STRT) laser pulse steered ground states population redistribution perylenequinone is characterized by employing time-dependent wave packet methods. It revealed that strengthened hydrogen bond favors S1 state, enhanced non-resonant excitation reduced energy exchange between external field during falling period, asymmetric pulses could increase excited-state population, leading improved efficiency. Compared traditional Gauss-type pulses, optimization STRT parameters (i.e., time, intensity, wavelength) bring more (>80%) promote subsequent processes responsible for enhancing therapeutic effects PDT. The present work offers valuable insights into interactions fields molecules, paving way optimized drug delivery systems with minimal damage normal tissue efficacy.

Язык: Английский

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Fighting Cancer with Photodynamic Therapy and Nanotechnologies: Current Challenges and Future Directions

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2969 - 2969

Опубликована: Март 25, 2025

Photodynamic therapy (PDT) is an innovative treatment that has recently been approved for clinical use and holds promise cancer patients. It offers several benefits, such as low systemic toxicity, minimal invasiveness, the ability to stimulate antitumor immune responses. For certain types of cancer, it shown positive results with few side effects. However, PDT still faces some challenges, including limited light penetration into deeper tumor tissues, uneven distribution photosensitizer (PS) can also affect healthy cells, difficulties posed by hypoxic microenvironment (TME). In conditions, PDT's effectiveness reduced due insufficient production reactive oxygen species, which limits destruction lead relapse. This review highlights recent advances in photosensitizers nanotechnologies are being developed improve PDT. focuses on multifunctional nanoplatforms nanoshuttles have preclinical studies, especially treating solid tumors. One key areas focus development PSs specifically target mitochondria treat deep-seated malignant New mitochondria-targeting nano-PSs designed better water solubility extended wavelength ranges, allowing them tumors more effectively, even challenging, environments. These advancements opening new doors treatment, when combined other therapeutic strategies. Moving forward, research should optimizing PDT, creating efficient drug delivery systems, developing smarter platforms. Ultimately, these efforts aim make a first-choice option

Язык: Английский

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