ACS Applied Polymer Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 9, 2024
Язык: Английский
Additive manufacturing, Год журнала: 2024, Номер unknown, С. 104443 - 104443
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
12
Advanced Drug Delivery Reviews, Год журнала: 2024, Номер unknown, С. 115504 - 115504
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
7
Drug Delivery and Translational Research, Год журнала: 2024, Номер unknown
Опубликована: Авг. 23, 2024
Abstract Mutable devices and dosage forms have the capacity to dynamically transform dimensionally, morphologically mechanically upon exposure non-mechanical external triggers. By leveraging these controllable transformations, systems can be used as minimally invasive alternatives implants residence devices, foregoing need for complex surgeries or endoscopies. 4D printing, fabrication of 3D-printed structures that evolve their shape, properties, functionality in response stimuli over time, allows production such devices. This study explores potential volumetric a novel vat photopolymerisation technology capable ultra-rapid printing speeds, by comparing its performance against established digital light processing (DLP) fabricating hydrogel-based drug-eluting Six hydrogel formulations consisting 2-(acryloyloxy)ethyl]trimethylammonium chloride solution, lithium phenyl-2,4,6-trimethylbenzoylphosphinate, varying molecular weights crosslinking monomer, poly(ethylene glycol) diacrylate, paracetamol model drug were prepared both technologies. Comprehensive studies conducted investigate swelling water sorption profiles, release kinetics, physicochemical properties each formulation. Expandable successfully fabricated within 7.5 s using shown display equivalent kinetics prints created DLP demonstrating release, swelling, better than those DLP-printed The reported findings shed on advantages limitations creating dynamic delivery provides direct comparison between two technologies, while highlighting promising further expanding growing repertoire pharmaceutical printing. Graphical
Язык: Английский
Процитировано
5
Advances in Colloid and Interface Science, Год журнала: 2024, Номер 331, С. 103232 - 103232
Опубликована: Июнь 14, 2024
Despite critical advances in regenerative medicine, the generation of definitive, reliable treatments for musculoskeletal diseases remains challenging. Gene therapy based on delivery therapeutic genetic sequences has strong value to offer effective, durable options decisively manage such disorders. Furthermore, scaffold-mediated gene provides powerful alternatives overcome hurdles associated with classical therapy, allowing spatiotemporal candidate genes sites injury. Among many scaffolds research, hydrogels raised increasing attention addition other potent systems (solid, hybrid scaffolds) due their versatility and competence as drug cell carriers tissue engineering wound dressing. Attractive functionalities include injectability, stimuli-responsiveness, self-healing, nanocomposition that may further allow upgrade them "intelligently" efficient mechanically platforms, rather than just inert vehicles. Such functionalized also be tuned successfully transfer a minimally invasive manner order protect cargos long-term effects. In light features, this review focuses demonstrates treatment disorders using procedures, from principles hydrogel functionalization methods applications hydrogel-mediated disorders, while remaining challenges are being discussed perspective translation patients. offering Scaffold-mediated therapy. attention. Functionalities including tune This introduces disorder
Язык: Английский
Процитировано
4
Advanced Therapeutics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 12, 2025
Abstract The incidence of type 2 diabetes (T2DM) increases significantly worldwide. Due to consistent hyperglycemia, insulin resistance, and chronic inflammation, T2DM patients encounter osteoporosis induced osteoporotic fracture risks. Antidiabetic drugs have been traditional therapies that seek control blood glucose, balance bone metabolism, favor systemic immunosuppression. However, such impact quality its nano‐scale features in the long‐term. Today, biomedical experts are continuously advancing drug delivery tools for local osteo‐immunomodulatory agents T2DM. It is demonstrated bioavailability release profile determine osteoconductivity outcomes therapeutics. This review focuses on introducing currently used vehicles fabrication techniques biomaterial‐based systems thoroughly examined. Furthermore, feasibility potential factors contributing bioactive surveyed. extent vivo responses described context current research examples. Targeted signaling mechanisms also assessed detail elucidate activated healing routes.
Язык: Английский
Процитировано
0
Carbohydrate Polymer Technologies and Applications, Год журнала: 2025, Номер unknown, С. 100702 - 100702
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Polymers, Год журнала: 2025, Номер 17(6), С. 765 - 765
Опубликована: Март 14, 2025
The architectures of hydrogels fabricated with stereolithography (SLA) 3D printing systems have played various roles in bioengineering applications. Typically, the SLA successively illuminated light to a layer photo-crosslinkable hydrogel precursors for fabrication hydrogels. These can be classified into point-scanning types and digital micromirror device (DMD) types. form layers by scanning focused light, while DMD illuminate 2D patterns each at once. Overall, were cost-effective allowed good shape fidelity uniform mechanical properties. As result, constructs used regenerate tissues develop lab-on-a-chip devices native tissue-like models.
Язык: Английский
Процитировано
0
Pharmaceutical Development and Technology, Год журнала: 2024, Номер 29(5), С. 445 - 456
Опубликована: Апрель 20, 2024
The digital light processing (DLP) printer has proven to be effective in biomedical and pharmaceutical applications, as its printing method does not induce shear a strong temperature on the resin. In addition, DLP good resolution print quality, which makes it possible complex structures with customized shape, being used for various purposes ranging from jewelry application areas. big disadvantage of is lack biocompatible non-toxic resin market. To overcome this limitation, an ideal use needed. must have appropriate properties, so that desired format printed when determined wavelength applied. Thus, aim work bring basic characteristics resins by minimum requirements start applications. obtaining devices such drug delivery systems. Furthermore, technology allows size, shape dosage, providing patient personalized treatment.
Язык: Английский
Процитировано
3
Materials Advances, Год журнала: 2024, Номер 5(17), С. 6957 - 6966
Опубликована: Янв. 1, 2024
Here, we present in situ rheology-Raman spectroscopy as a hydrogel characterization method for simultaneous observation of gelation and polymerization.
Язык: Английский
Процитировано
2
Drug Delivery and Translational Research, Год журнала: 2024, Номер unknown
Опубликована: Окт. 18, 2024
Abstract Vat photopolymerisation 3D printing is being actively explored for manufacturing personalised medicines due to its high dimensional accuracy and lack of heat application. However, several challenges have hindered clinical translation, including the inadequate speeds, resins that give soluble matrices, need non-destructive quality control measures. In this study, first time, a rapid approach producing water-soluble vat photopolymerised matrices means non-destructively verifying their drug content were investigated. Volumetric printing, novel form photopolymerisation, was used fabricate warfarin-loaded 3D-printed tablets (printlets). Eight different formulations containing varying amounts warfarin (0.5–6.0% w/w) print two sized torus-shaped printlets within 6.5 11.1 s. Nuclear magnetic resonance (NMR) spectroscopy revealed presence only trace unreacted acrylate monomers, suggesting reaction had occurred near completion. All completely solubilised released entire load 2.5 7 h. NIR (NIRS) verify dose loaded into printlets. The partial least square regression model built showed strong linearity (R 2 = 0.980), in predicting loading test sample (RMSEP 0.205%). Therefore, study advances pharmaceutical by demonstrating feasibility via volumetric quantifying with NIRS. Graphical abstract
Язык: Английский
Процитировано
1