Recent Developments in 3D-(Bio)printed Hydrogels as Wound Dressings

Gels, Journal Year: 2024, Volume and Issue: 10(2), P. 147 - 147

Published: Feb. 14, 2024

Wound healing is a physiological process occurring after the onset of skin lesion aiming to reconstruct dermal barrier between external environment and body. Depending on nature duration process, wounds are classified as acute (e.g., trauma, surgical wounds) chronic diabetic ulcers) wounds. The latter take several months heal or do not (non-healing wounds), usually prone microbial infection represent an important source morbidity since they affect millions people worldwide. Typical wound treatments comprise debridement, grafts/flaps) non-surgical topical formulations, dressings) methods. Modern experimental approaches include among others three dimensional (3D)-(bio)printed dressings. present paper reviews recently developed 3D (bio)printed hydrogels for applications, especially focusing results their in vitro vivo assessment. advanced hydrogel constructs were printed using different types bioinks natural and/or synthetic polymers mixtures with biological materials) printing methods extrusion, digital light processing, coaxial microfluidic bioprinting, etc.) incorporated various bioactive agents growth factors, antibiotics, antibacterial agents, nanoparticles, cells fibroblasts, keratinocytes, mesenchymal stem cells, endothelial etc.).

Language: Английский

---

Engineered hydrogel platform for diabetic wound healing

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160379 - 160379

Published: Feb. 1, 2025

Language: Английский

---

Thiolation‐Based Protein–Protein Hydrogels for Improved Wound Healing

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(14)

Published: Feb. 2, 2024

Abstract The limitations of protein‐based hydrogels, including their insufficient mechanical properties and restricted biological functions, arise from the highly specific functions proteins as natural building blocks. A potential solution to overcome these shortcomings is development protein–protein which integrate structural functional proteins. In this study, a hydrogel formed by crosslinking bovine serum albumin (BSA) genetically engineered intrinsically disordered collagen‐like protein (CLP) through Ag─S bonding introduced. approach involves thiolating lysine residues BSA CLP with Ag + ions, utilizing thiolation free‐cysteines CLP. resulting hydrogels exhibit exceptional properties, notable plasticity, inherent self‐healing capabilities, gel–sol transition in response redox conditions. comparison standalone demonstrate enhanced cellular viability, improved migration. vivo experiments provide conclusive evidence accelerated wound healing, observed not only murine models streptozotocin (Step)‐induced diabetes but also zebrafish subjected UV‐burn injuries. Detailed mechanistic insights, combined assessments proinflammatory cytokines expression epidermal differentiation‐related proteins, robustly validate hydrogel's effectiveness promoting repair.

Language: Английский

---

Wound microenvironment self-adaptive all-in-one hydrogel for rapid healing of the diabetic wound

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(8), P. 2070 - 2082

Published: Jan. 1, 2024

An innovative wound microenvironment self-adaptive hydrogel, that encapsulates drug-loaded liposomes was developed to promote the healing of diabetic wounds.

Language: Английский

---

Advancing Diabetic Wound Care: The Role of Copper-containing Hydrogels

Heliyon, Journal Year: 2024, Volume and Issue: 10(20), P. e38481 - e38481

Published: Sept. 26, 2024

Language: Английский

---

Hydrogel‐Based Smart Materials for Wound Healing and Sensing

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT Recent advancements in hydrogel‐based flexible materials have revolutionized wound healing and monitoring strategies. These offer promising solutions for medical treatment real‐time diagnostics. Their rich water content, biocompatibility, tunable properties closely mimic the natural extracellular matrix, supporting regeneration. Unlike traditional materials, systems address critical issues such as material stability toxicity while integrating advanced devices. This review highlights latest innovations materials. It focuses on flexibility, potential integration with smart systems. The covers design principles fabrication techniques nanofibers, elastomers, conducting polymers. also discusses development of electronic skin innovative dressings. In addition, explains how sensing capabilities, stimuli‐responsive functions, antibacterial agents are incorporated into these Finally, article examines challenges future directions field. emphasizes transformative multifunctional improving continuous monitoring.

Language: Английский

---

Biogenic synthesis of dual-emission chlorophyll-rich carbon quantum dots for detection of toxic heavy metal ions – Hg(ii) and As(iii) in water and mouse fibroblast cell line NIH-3T3

Environmental Science Nano, Journal Year: 2024, Volume and Issue: 11(4), P. 1636 - 1653

Published: Jan. 1, 2024

Due to the excessive residues and serious adverse effects, it is urgent develop an efficient method detect Hg 2+ As 3+ in drinking water protect human health.

Language: Английский

---

Advancements in amyloid-based biological materials for healthcare, environmental and sensing applications

Materials Advances, Journal Year: 2024, Volume and Issue: 5(10), P. 4078 - 4090

Published: Jan. 1, 2024

The review discusses advancements in amyloid fibril-based materials and their applications healthcare, sensing, the environment. These biomaterials are sustainable greener alternatives to conventional synthetic materials.

Language: Английский

---

Nanocomposite Conductive r(GO/BSA) Hydrogel as an Effective Dressing for Rapid Chronic Diabetic Wound Healing

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 705, P. 135553 - 135553

Published: Oct. 13, 2024

Language: Английский

---

3D Printing of Proteins Via Temperature‐Dependent Amyloid Aggregation

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Abstract 3D printing of protein materials for creating bioactive scaffolds has attracted significant interest. However, achieving controllable and stable while replicating the ordered structure found in natural remains a key challenge. Herein, universally applicable temperature‐dependent aggregation (TPA) strategy is reported to manipulate unfolding, relaxation, reorganization chains enable amyloid‐like proteins. The disruption internal disulfide bonds induces unfolding relaxation protein, leading formation an amorphous sol through chain entanglement as primary cross‐linking points. These relaxed further aggregate conformational transition initiate rich β‐sheet structures at high temperature, resulting gel with nanocrystals serving secondary This facilitates precise extrusion‐based proteinaceous hierarchically structure. biomedical potential this 3D‐printed scaffold preliminarily validated its biomineralization capability following application bone tissue regeneration using rat skull defect models. demonstrates facile approach structural proteins vitro holds great field protein‐based scaffolds.

Language: Английский

---