Conductive Hybrid Hydrogel of Carbon Nanotubes-Protein-Cellulose: In Vivo Treatment of Diabetic Wound via Photothermal Therapy and Tracking Real-Time Wound Assessment via Photoacoustic Imaging

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Diabetic wounds pose significant challenges in healthcare due to their slow healing rates and susceptibility infections, leading severe complications. In this study, we developed a carbon nanotube-based conductive protein-cellulose hydrogel designed enhance wound through photothermal therapy. The hydrogel's unique properties, including high electrical conductivity biocompatibility, were assessed vitro for cell viability, hemolysis, histological evaluations. vivo studies on diabetic rats revealed that the significantly improved healing, with faster closure rates. These results supported by noticeable reductions inflammatory markers enhanced blood vessel formation, as observed immunohistochemical analysis. Additionally, photoacoustic imaging offered real-time data flow tissue oxygen levels, showing positive trends process. Overall, these findings point potential of hydrogel, especially when paired therapy, serve an effective treatment wounds, offering promising possibilities care strategies.

Язык: Английский

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Electrospun metal–organic framework-based nanofibers with natural therapeutic agents for enhanced diabetic wound healing

Discover Materials, Год журнала: 2025, Номер 5(1)

Опубликована: Март 26, 2025

Язык: Английский

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Novel bioink derived from low methoxyl pectin, gelatin and aloe vera as natural biomaterials for fabricating scaffolds encapsulated with living cells by 3D bioprinting

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143364 - 143364

Опубликована: Апрель 1, 2025

Язык: Английский

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Enhancing Photodynamic Therapy through Magnetic Targeting: A Biochemical Perspective

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Язык: Английский

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Biogenic synthesis of dual-emission chlorophyll-rich carbon quantum dots for detection of toxic heavy metal ions – Hg(ii) and As(iii) in water and mouse fibroblast cell line NIH-3T3

Environmental Science Nano, Год журнала: 2024, Номер 11(4), С. 1636 - 1653

Опубликована: Янв. 1, 2024

Due to the excessive residues and serious adverse effects, it is urgent develop an efficient method detect Hg 2+ As 3+ in drinking water protect human health.

Язык: Английский

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Trends in Protein Derived Materials for Wound Care Applications

Biomaterials Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Natural resource based polymers, especially those derived from proteins, have attracted significant attention for their potential utilization in advanced wound care applications. Protein materials provide superior biocompatibility, biodegradability, and other functionalities compared to conventional dressings. The effectiveness of various fabrication techniques, such as electrospinning, phase separation, self-assembly, ball milling, is examined the context developing protein-based healing. These methods produce a wide range forms, including hydrogels, scaffolds, sponges, films, bioinspired nanomaterials, each designed specific types wounds different stages This review presents comprehensive analysis recent research that investigates transformation proteins into healing Our focus on essential keratin, collagen, gelatin, silk, zein, albumin, we emphasize distinct traits roles management. Protein-based show promising biomedical engineering, offering improved capabilities reduced risks infection. It crucial explore use these clinical settings while also addressing challenges may arise commercialization future.

Язык: Английский

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In Vivo Wound Healing in Drosophila melanogaster and Mouse Models: Synergistic Effect of Bovine Serum Albumin and Graphene Quantum Dots

ACS Applied Bio Materials, Год журнала: 2023, Номер 6(12), С. 5531 - 5540

Опубликована: Дек. 1, 2023

Bovine serum albumin (BSA)-based biomaterials have garnered significant attention for their remarkable potential in wound healing, primarily due to effective biological actions addressing the skin inflammation phase and mitigating hypoalbuminemia. Motivated by these attributes, a nanocomposite hydrogel is developed blending BSA with poly(vinyl alcohol) (PVA), complemented incorporation of graphene quantum dot (GQD). The FTIR study establishes hydrogen-bonding interaction between −NH2 groups −OH group PVA. Microscopic investigations establish that dispersion GQDs an average size 22.5 nm results smoothening surface nanocomposite. reveals excellent swelling attributes about 920% period 6 h its optimum cross-linking condition. Furthermore, exhibits water vapor transmission rate 8.45 mg cm–2 h–1, akin wounded skin. PVA/BSA@GQD nanocomposite's antibacterial efficacy evaluated against Morganella morganii bacteria, showing 99% killing, while cytotoxicity assay HeLa cells exhibited minimum cell viability 76% at 20 μM concentration, which ideal dressing material. In vivo healing are conducted on Drosophila, showcasing 100% closure within 4 h. This outcome further substantiated through studies involving mice, where complete re-epithelialization achieved span 13 days. combined as

Язык: Английский

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3D printing and bioprinting in the battle against diabetes and its chronic complications

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Май 28, 2024

Diabetes is a metabolic disorder characterized by high blood sugar. Uncontrolled glucose affects the circulatory system in an organism intervening circulation. The can lead to macrovascular (large vessels) and microvascular (small complications. Due this, vital organs (notably brain, eyes, feet, heart, kidneys, lungs nerves) get worsen diabetic patients if not treated at earliest. Therefore, acquiring treatment appropriate time very important for managing diabetes other complications that are caused due diabetes. root cause occurrence of various health uncontrolled levels. This review presents consolidated account applications types three-dimensional (3D) printing bioprinting technologies treating as well impaired Herein, development biosensors (for diagnosis), oral drug formulations, transdermal carriers, orthotic insoles scaffolds treatment) discussed. Next fabrication 3D bioprinted cell-seeded hydrogels (pancreas engineering producing insulin bone defects) explained. As final application, disease models high-throughput screening ant-diabetic drugs Lastly, challenges future perspective associated with use against its related chronic have been put forward.

Язык: Английский

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Integrative Analysis of Lactylome and Proteome of Hypertrophic Scar To Identify Pathways or Proteins Associated with Disease Development

Journal of Proteome Research, Год журнала: 2024, Номер 23(8), С. 3367 - 3382

Опубликована: Июль 16, 2024

Lactylation (Kla), a recently discovered post-translational modification derived from lactate, plays crucial roles in various cellular processes. However, the specific influence of lactylation on biological processes underlying hypertrophic scar formation remains unclear. In this study, we present comprehensive profiling lactylome and proteome both scars adjacent normal skin tissues. A total 1023 Kla sites originating 338 nonhistone proteins were identified based analysis. Proteome analysis samples revealed identification 2008 proteins. It is worth noting that exhibits preference for genes associated with ribosome function as well glycolysis/gluconeogenesis Furthermore, functional enrichment demonstrated differentially lactyled are primarily involved proteoglycans, HIF-1, AMPK signaling pathways. The combined data highlighted significant upregulation 14 Overall, our investigation unveiled involvement protein regulation glycolysis/gluconeogenesis, potentially contributing to scars.

Язык: Английский

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Synthesis and Comprehensive Characterization of PVA/Chitosan/Cu Nanowires Wound Dressing Hydrogel for Effective In Vitro Wound Healing

Journal of Industrial and Engineering Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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