Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114704 - 114704
Опубликована: Апрель 1, 2025
Язык: Английский
Bone Research, Год журнала: 2024, Номер 12(1)
Опубликована: Май 14, 2024
Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue. Its high recurrence rate and impaired restoration of deficiencies are major challenges treatment. Microbes have evolved numerous mechanisms to effectively evade host intrinsic adaptive immune attacks persistently localize the host, such as drug-resistant bacteria, biofilms, persister cells, intracellular small colony variants (SCVs). Moreover, microbial-mediated dysregulation microenvironment impedes regeneration process, leading defect repair. Despite advances surgical strategies drug applications for treatment infections within last decade, remain clinical management. The development application tissue engineering materials provided new infections, but comprehensive review their research progress lacking. This discusses critical pathogenic microbes skeletal system immunomodulatory effects on regeneration, highlights prospects technologies infections. It will inform translation antimicrobial repair management
Язык: Английский
Процитировано
42
Advances in Colloid and Interface Science, Год журнала: 2024, Номер 327, С. 103155 - 103155
Опубликована: Апрель 16, 2024
Язык: Английский
Процитировано
25
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Март 5, 2025
The successful approval of peptide-based drugs can be attributed to a collaborative effort across multiple disciplines. integration novel drug design and synthesis techniques, display library technology, delivery systems, bioengineering advancements, artificial intelligence have significantly expedited the development groundbreaking drugs, effectively addressing obstacles associated with their character, such as rapid clearance degradation, necessitating subcutaneous injection leading increasing patient discomfort, ultimately advancing translational research efforts. Peptides are presently employed in management diagnosis diverse array medical conditions, diabetes mellitus, weight loss, oncology, rare diseases, additionally garnering interest facilitating targeted platforms advancement vaccines. This paper provides an overview present market clinical trial progress therapeutics, platforms, It examines key areas through literature analysis emphasizes structural modification principles well recent advancements screening, design, technologies. accelerated including peptide-drug complexes, new vaccines, innovative diagnostic reagents, has potential promote era precise customization disease therapeutic schedule.
Язык: Английский
Процитировано
5
Progress in Materials Science, Год журнала: 2025, Номер 151, С. 101428 - 101428
Опубликована: Янв. 9, 2025
Язык: Английский
Процитировано
4
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 19, 2025
Soft robotics has undergone considerable progress driven by materials that can effectively transduce external stimuli into mechanical actuation. Here, we report the development of a photothermal-responsive hydrogel actuator with shape memory capabilities inspired adaptive locomotion sea cucumbers. This is based on cucumber peptides (SCP) and liquid metal (LM) network responsive to near-infrared (NIR) light. Upon NIR irradiation, undergoes phase transition from swollen collapsed state, resulting in controlled volumetric change. Incorporating polymer (SMP) matrix facilitates actuator's retention its deformed configuration following stimulus removal, thereby enabling intricate, multiphase transformations. SCP/LM overcomes limitations traditional hydrogels achieves good stretchability (3,000%) enough adhesion (21 kPa), exhibiting no toxicity human cells. Furthermore, exhibited significant bending complex deformation within 100 s exposure. offers new opportunities for soft biomedical applications, showcasing potential pathway incorporating next generation smart devices.
Язык: Английский
Процитировано
3
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 28, 2025
Patients and healthcare systems face significant social financial challenges due to the increasing number of individuals with chronic external internal wounds that fail heal. The complexity healing process remains a serious health concern, despite effectiveness conventional wound dressings in promoting healing. Recent advancements materials science fabrication techniques have led development innovative enhance To further expedite process, novel approaches such as nanoparticles, 3D-printed dressings, biomolecule-infused emerged, along cell-based methods. Additionally, gene therapy technologies are being harnessed generate stem cell derivatives more functional, selective, responsive than their natural counterparts. This review highlights potential biomaterials, 3D bioprinting, gene- therapies However, it also underscores necessity for research address existing integrate these strategies into standard clinical practice.
Язык: Английский
Процитировано
3
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Май 28, 2024
The repair of irregular bone tissue suffers severe clinical problems due to the scarcity an appropriate therapeutic carrier that can match dynamic and complex damage. Fortunately, stimuli-responsive in situ hydrogel systems are triggered by a special microenvironment could be ideal method regenerating because injectability, gelatin, spatiotemporally tunable drug release. Herein, we introduce two main stimulus-response approaches, exogenous endogenous, forming hydrogels engineering. First, summarize specific distinct responses extensive range external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) form created from biocompatible materials modified various functional groups or hybrid nanoparticles. Furthermore, “smart” hydrogels, which respond endogenous physiological environmental temperature, pH, enzyme, etc.), achieve gelation one injection vivo without additional intervention. Moreover, mild chemistry response-mediated also offer fascinating prospects engineering, such as Diels–Alder, Michael addition, thiol-Michael Schiff reactions, etc. recent developments challenges smart their application administration engineering discussed this review. It is anticipated advanced strategies innovative ideas will exploited field increase quality life for patients with
Язык: Английский
Процитировано
11
Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 85 - 107
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
1
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 29, 2025
Infectious bone defects present a substantial clinical challenge due to the complex interplay between infection control and regeneration. These often result from trauma, autoimmune diseases, infections, or tumors, requiring nuanced approach that simultaneously addresses promotes tissue repair. Recent advances in engineering materials science, particularly nanomaterials nano-drug formulations, have led development of bifunctional biomaterials with combined osteogenic antibacterial properties. offer an alternative traditional grafts, minimizing complications such as multiple surgeries, high antibiotic dosages, lengthy recovery periods. This review examines repair mechanisms infectious microenvironment highlights various foster both anti-infective processes. Emerging design strategies are also discussed provide forward-looking perspective on treating clinically significant outcomes.
Язык: Английский
Процитировано
1
Biomaterials Science, Год журнала: 2024, Номер 12(19), С. 4855 - 4874
Опубликована: Янв. 1, 2024
In recent years, supramolecular hydrogels have made groundbreaking research progress in biomedical fields such as drug delivery, biosensing, imaging analysis, and tissue engineering. Peptides, with their unique characteristics of facile preparation, low immunogenicity easy biodegradability, are commonly used building blocks hydrogels. Peptide-based loaded drugs, prepared
Язык: Английский
Процитировано
8