Chemistry - A European Journal, Год журнала: 2024, Номер unknown
Опубликована: Окт. 15, 2024
Abstract Nickel‐catalyzed asymmetric intramolecular addition of aryl halides to α‐ketoamides has been achieved afford chiral 3‐substituted‐3‐hydroxy‐2‐oxindoles in excellent yields and high enantioselectivities (up 99 % yield 98 ee), which provides efficient access valuable molecules containing 3‐hydroxy‐2‐oxindole core. The gram‐scale reaction proved the potential utility methodology.
Язык: Английский
The Chemical Record, Год журнала: 2025, Номер unknown
Опубликована: Апрель 21, 2025
Abstract α ‐Ketoamides are privileged chemical entities featuring a carbonyl group bonded to an amide. Bearing two pronucleophilic and proelectrophilic sites, this structural scaffold exhibits distinct properties unparalleled biological activity. Owing its wide application in medicinal, agricultural, synthetic chemistry, methods for assembling moiety ever‐growing demand. With the increasing focus on green synthesis, traditional routes ‐ketoamides have faded recent years giving rise development of photocatalytic, electrosynthetic, microwave‐assisted catalytic protocols. We hereby provide comprehensive critical summary all advancements witnessed field from 2016 present.
Язык: Английский
Процитировано
0
Organic Letters, Год журнала: 2025, Номер unknown
Опубликована: Апрель 24, 2025
A novel Ru(II)-catalyzed domino reaction, comprising alkylation, cyclization, and oxidation of 2-aminophenethanols with benzyl alcohols, has been developed for the synthesis 3-hydroxyindolin-2-ones. This transformation exhibits excellent synthetic efficiency, enabling selective formation four or three σ bonds, one π bond, quaternary carbon center in step under identical conditions. Furthermore, it provides a versatile approach to 3-hydroxyindolin-2-one frameworks distinct substituents at 1- 3-positions.
Язык: Английский
Процитировано
0
Applied Catalysis A General, Год журнала: 2024, Номер unknown, С. 120053 - 120053
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1
Chemistry - A European Journal, Год журнала: 2024, Номер unknown
Опубликована: Окт. 15, 2024
Abstract Nickel‐catalyzed asymmetric intramolecular addition of aryl halides to α‐ketoamides has been achieved afford chiral 3‐substituted‐3‐hydroxy‐2‐oxindoles in excellent yields and high enantioselectivities (up 99 % yield 98 ee), which provides efficient access valuable molecules containing 3‐hydroxy‐2‐oxindole core. The gram‐scale reaction proved the potential utility methodology.
Язык: Английский
Процитировано
0