Enantioselective Synthesis of 3‐Hydroxy‐2‐Oxindoles via Ni‐Catalyzed Asymmetric Addition of Aromatic Bromides to α‐Ketoamides DOI

Jiangyan Tian,

Xuening Li,

Tao Shou

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Nickel‐catalyzed asymmetric intramolecular addition of aryl halides to α‐ketoamides has been achieved afford chiral 3‐substituted‐3‐hydroxy‐2‐oxindoles in excellent yields and high enantioselectivities (up 99 % yield 98 ee), which provides efficient access valuable molecules containing 3‐hydroxy‐2‐oxindole core. The gram‐scale reaction proved the potential utility methodology.

Language: Английский

Recent Advances in the Catalytic Synthesis of α‐Ketoamides DOI

Mathew B. Aaron,

P. Devi, Gopinathan Anilkumar

et al.

The Chemical Record, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract α ‐Ketoamides are privileged chemical entities featuring a carbonyl group bonded to an amide. Bearing two pronucleophilic and proelectrophilic sites, this structural scaffold exhibits distinct properties unparalleled biological activity. Owing its wide application in medicinal, agricultural, synthetic chemistry, methods for assembling moiety ever‐growing demand. With the increasing focus on green synthesis, traditional routes ‐ketoamides have faded recent years giving rise development of photocatalytic, electrosynthetic, microwave‐assisted catalytic protocols. We hereby provide comprehensive critical summary all advancements witnessed field from 2016 present.

Language: Английский

Citations

0
Construction of 3-Hydroxyindolin-2-ones via Ru(II)-Catalyzed Domino Alkylation/Cyclization/Oxidation of 2-Aminophenethanols DOI

Chuanhu Wang,

Huang Jing-wen,

Bo Deng

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

A novel Ru(II)-catalyzed domino reaction, comprising alkylation, cyclization, and oxidation of 2-aminophenethanols with benzyl alcohols, has been developed for the synthesis 3-hydroxyindolin-2-ones. This transformation exhibits excellent synthetic efficiency, enabling selective formation four or three σ bonds, one π bond, quaternary carbon center in step under identical conditions. Furthermore, it provides a versatile approach to 3-hydroxyindolin-2-one frameworks distinct substituents at 1- 3-positions.

Language: Английский

Citations

0
Highly Dispersed Pd-Nanoparticles in Vanadium Oxide Supported Zeolite-Y for C-C Coupling Reaction through C-Cl Bond Activation DOI

Tonmoy J. Bora,

Nand Kishor Gour, Lakshi Saikia

et al.

Applied Catalysis A General, Journal Year: 2024, Volume and Issue: unknown, P. 120053 - 120053

Published: Dec. 1, 2024

Language: Английский

Citations

1
Enantioselective Synthesis of 3‐Hydroxy‐2‐Oxindoles via Ni‐Catalyzed Asymmetric Addition of Aromatic Bromides to α‐Ketoamides DOI

Jiangyan Tian,

Xuening Li,

Tao Shou

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Nickel‐catalyzed asymmetric intramolecular addition of aryl halides to α‐ketoamides has been achieved afford chiral 3‐substituted‐3‐hydroxy‐2‐oxindoles in excellent yields and high enantioselectivities (up 99 % yield 98 ee), which provides efficient access valuable molecules containing 3‐hydroxy‐2‐oxindole core. The gram‐scale reaction proved the potential utility methodology.

Language: Английский

Citations

0