Pd(II)‐Catalyzed C3‐Alkylation and Annulation of Indole‐2‐carboxamides with Maleimides: Access to Fused β‐Carbolinone Frameworks
Srinivasa Rao Kancharla,
Syeda Fatima Zeenath,
Rajashaker Bantu
и другие.
ChemistrySelect,
Год журнала:
2025,
Номер
10(21)
Опубликована: Июнь 1, 2025
Abstract
A
temperature‐controlled
oxidative
addition
and
annulation
of
maleimides
onto
1H‐indole‐2‐carboxamides
has
been
developed
to
the
synthesis
angularly
fused
β‐carbolinone
frameworks
using
Pd(OAc)
2
as
a
catalyst
Cu(OAc)
co‐oxidant.
It
is
novel
atom‐economical
method
for
one‐pot
highly
functionalized
β‐carbolinones.
modular
approach
3‐(indol‐3‐yl)maleimides
beta‐carbolines
by
mere
change
in
temperature.
This
offers
several
advantages
such
operational
simplicity,
cleaner
reaction
profiles,
wide
substrate
scope
high
functional
group
tolerance.
first
report
on
β‐carbolines
through
C─H
bond
activation
1H‐indole‐2‐carboxamides.
Язык: Английский
Late-Stage Modification of Peptides with Maleimides through Palladium-Catalyzed β-C(sp3)–H Alkylation
Organic Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 4, 2024
Transition-metal-catalyzed
C-H
activation
has
proven
to
be
a
powerful
tool
for
the
late-stage
modification
of
peptides.
We
herein
report
method
site-selective
alkylation
peptides
with
maleimides
through
Pd-catalyzed
β-C(sp
Язык: Английский
Dual Inert C–H Bond Site-Selective Activations Enabled by Pd/Norbornene-Mediated Cascade Cyclization toward Medium-Sized Polyheterocyclic Methylene Sulfoximines
Organic Letters,
Год журнала:
2024,
Номер
26(49), С. 10548 - 10552
Опубликована: Ноя. 28, 2024
A
Pd/norbornene-mediated
three-component
modular
one-step
reaction
facilitated
by
dual
C-H
bond
activation
and
cascade
cyclization
is
reported.
This
procedure
uses
norbornene
as
a
catalyst
in
the
Catellani-type
an
alkylating
building
block
to
accomplish
unactivated
functionalization
protocol,
which
results
production
of
polyheterocyclic
eight-membered
sulfoximines
with
indene-fused
moiety.
mild,
scalable
protocol's
wide
substrate
range
makes
it
ideal
for
site-selective
at
highly
chemoselective
aryl
sites.
Язык: Английский