Dual Inert C–H Bond Site-Selective Activations Enabled by Pd/Norbornene-Mediated Cascade Cyclization toward Medium-Sized Polyheterocyclic Methylene Sulfoximines DOI
Wei Li, Xun Fang, Xiaojuan Chen

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(49), P. 10548 - 10552

Published: Nov. 28, 2024

A Pd/norbornene-mediated three-component modular one-step reaction facilitated by dual C-H bond activation and cascade cyclization is reported. This procedure uses norbornene as a catalyst in the Catellani-type an alkylating building block to accomplish unactivated functionalization protocol, which results production of polyheterocyclic eight-membered sulfoximines with indene-fused moiety. mild, scalable protocol's wide substrate range makes it ideal for site-selective at highly chemoselective aryl sites.

Language: Английский

Pd(II)‐Catalyzed C3‐Alkylation and Annulation of Indole‐2‐carboxamides with Maleimides: Access to Fused β‐Carbolinone Frameworks DOI

Srinivasa Rao Kancharla,

Syeda Fatima Zeenath,

Rajashaker Bantu

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(21)

Published: June 1, 2025

Abstract A temperature‐controlled oxidative addition and annulation of maleimides onto 1H‐indole‐2‐carboxamides has been developed to the synthesis angularly fused β‐carbolinone frameworks using Pd(OAc) 2 as a catalyst Cu(OAc) co‐oxidant. It is novel atom‐economical method for one‐pot highly functionalized β‐carbolinones. modular approach 3‐(indol‐3‐yl)maleimides beta‐carbolines by mere change in temperature. This offers several advantages such operational simplicity, cleaner reaction profiles, wide substrate scope high functional group tolerance. first report on β‐carbolines through C─H bond activation 1H‐indole‐2‐carboxamides.

Language: Английский

Citations

0
Late-Stage Modification of Peptides with Maleimides through Palladium-Catalyzed β-C(sp3)–H Alkylation DOI

Fengjie Lu,

Yujie Geng,

Huihui Wang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Transition-metal-catalyzed C-H activation has proven to be a powerful tool for the late-stage modification of peptides. We herein report method site-selective alkylation peptides with maleimides through Pd-catalyzed β-C(sp

Language: Английский

Citations

1
Dual Inert C–H Bond Site-Selective Activations Enabled by Pd/Norbornene-Mediated Cascade Cyclization toward Medium-Sized Polyheterocyclic Methylene Sulfoximines DOI
Wei Li, Xun Fang, Xiaojuan Chen

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(49), P. 10548 - 10552

Published: Nov. 28, 2024

A Pd/norbornene-mediated three-component modular one-step reaction facilitated by dual C-H bond activation and cascade cyclization is reported. This procedure uses norbornene as a catalyst in the Catellani-type an alkylating building block to accomplish unactivated functionalization protocol, which results production of polyheterocyclic eight-membered sulfoximines with indene-fused moiety. mild, scalable protocol's wide substrate range makes it ideal for site-selective at highly chemoselective aryl sites.

Language: Английский

Citations

0