Palladium-catalysed alleneamination of γ,δ-unsaturated hydrazones with propargylic acetates: access to tetrahydropyridazines bearing allenes

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Herein, we reported a palladium-catalysed alleneamination of γ,δ-unsaturated hydrazones with propargylic acetates, which provides an efficient approach for the synthesis tetrahydropyridazine bearing allenes in moderate to good yields.

Язык: Английский

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Access to C5-Sulfonylated Tetrahydropyridazines via Photoinduced Cascade Sulfonylation-Cyclization of N-Cinnamyl Aldehyde Hydrazones

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Direct installation of a sulfonyl functional group into the C5-position tetrahydropyridazine was achieved using N'-benzylidene-N-cinnamylacetohydrazide as new building skeleton via photocatalytic carbosulfonylation/annulation procedure. Various substituted C5-sulfonylated tetrahydropyridazines were obtained in good to excellent yields employing aryl- or alkylsulfonyl chlorides radical sources. This reaction realized through selective addition C2 position cinnamyl followed by 6-endo-trig annulation hydrazone CH═N bond.

Язык: Английский

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Visible Light-Induced Radical-Cascade Difluoroalkylation/Cyclization of Unsaturated Aldehyde Hydrazones for the Synthesis of Difluoroalkylated Dihydropyrazoles and Tetrahydropyridazines

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 5, 2025

Visible light-induced radical 5/6-endo-trig difluoroalkylation/cyclization of N-allyl and homoallyl aldehyde hydrazones with various fluoroalkyl bromides has been achieved. The reaction was carried out alkyl difluoroacetates difluoroacetamide as difluoroalkylation reagents Eosin Y an organic photocatalyst. Various difluoroalkylated dihydropyrazoles tetrahydropyridazines were obtained under metal-free mild conditions.

Язык: Английский

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Assembling Molecular Semiconductor Composite for Enhanced Photocatalytic Cyclohexene Oxidation

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

A molecular semiconductor composite was assembled by integrating atomically precise Ti 12 -oxo clusters and phosphotungstic acid into a cocrystal system.

Язык: Английский

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