Synthesis of Axially Chiral N-Arylpyrroles through the Enantioselective Annulation of Yne-Allylic Esters with a Cooperative Copper-Squaramide Catalysis DOI

Maoyan Liao,

Jixing Li,

Haihui Zhu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

We present a strategy involving central-to-axial chirality conversion for the construction of axially chiral N-arylpyrroles via cooperative copper-squaramide-catalyzed remote propargylic amination/ring closure/rearomatization cascade from yne-allylic esters. The reaction exhibits excellent chemical efficiency and enantioselectivity, good conversion. use squaramide as cocatalyst is crucial success.

Язык: Английский

Asymmetric hydrogenation of α-pyrrolyl terminal alkenes: an easy access to enantioenriched pyrroles bearing a C2 Me-substituted stereogenic center DOI Creative Commons

Ao Zhou,

Nianxin Rong,

Han Zhuang

и другие.

Green Synthesis and Catalysis, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Synthesis of Axially Chiral N-Arylpyrroles through the Enantioselective Annulation of Yne-Allylic Esters with a Cooperative Copper-Squaramide Catalysis DOI

Maoyan Liao,

Jixing Li,

Haihui Zhu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

We present a strategy involving central-to-axial chirality conversion for the construction of axially chiral N-arylpyrroles via cooperative copper-squaramide-catalyzed remote propargylic amination/ring closure/rearomatization cascade from yne-allylic esters. The reaction exhibits excellent chemical efficiency and enantioselectivity, good conversion. use squaramide as cocatalyst is crucial success.

Язык: Английский

Процитировано

0