Asymmetric hydrogenation of α-pyrrolyl terminal alkenes: an easy access to enantioenriched pyrroles bearing a C2 Me-substituted stereogenic center
Ao Zhou,
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Nianxin Rong,
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Han Zhuang
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et al.
Green Synthesis and Catalysis,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Language: Английский
Synthesis of Axially Chiral N-Arylpyrroles through the Enantioselective Annulation of Yne-Allylic Esters with a Cooperative Copper-Squaramide Catalysis
Maoyan Liao,
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Jixing Li,
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Haihui Zhu
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et al.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 8, 2025
We
present
a
strategy
involving
central-to-axial
chirality
conversion
for
the
construction
of
axially
chiral
N-arylpyrroles
via
cooperative
copper-squaramide-catalyzed
remote
propargylic
amination/ring
closure/rearomatization
cascade
from
yne-allylic
esters.
The
reaction
exhibits
excellent
chemical
efficiency
and
enantioselectivity,
good
conversion.
use
squaramide
as
cocatalyst
is
crucial
success.
Language: Английский