Recent Advances in Porphyrin-Based Covalent Organic Frameworks for Synergistic Photodynamic and Photothermal Therapy DOI Creative Commons
Qi Cheng, Jiayi Chen, Yingli Qu

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(12), С. 1625 - 1625

Опубликована: Дек. 22, 2024

Porphyrin’s excellent biocompatibility and modifiability make it a widely studied photoactive material. However, its large π-bond conjugated structure leads to aggregation precipitation in physiological solutions, limiting the biomedical applications of porphyrin-based materials. It has been demonstrated through research that fabricating porphyrin molecules into nanoscale covalent organic frameworks (COFs) structures can circumvent issues such as poor dispersibility resulting from hydrophobicity, thereby significantly augmenting photoactivity Porphyrin-based COF materials exert combined photodynamic photothermal effects, circumventing limitations therapy (PDT) due hypoxia (PTT) heat shock proteins or adverse impact excessive on protein activity normal tissue. Furthermore, porous COFs facilitates circulation oxygen reactive species promotes sufficient contact with lesion site for therapeutic functions. This review covers recent progress regarding treating malignant tumors venous thrombosis antibacterial anti-inflammatory uses via PDT PTT. By summarizing relevant design strategies, ranging molecular functional application, this provides reference basis enhanced phototherapy application aims offer valuable insights more effective synthesis existing experimental data, paving way their future preclinical utilization.

Язык: Английский

Evolution of nMOFs in photodynamic therapy: from porphyrins to chlorins and bacteriochlorins for better efficacy DOI Creative Commons
Yutao Zou, Jiayi Chen, Yingli Qu

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 18, 2025

Photodynamic therapy (PDT) has gained significant attention due to its non-invasive nature, low cost, and ease of operation. Nanoscale metal-organic frameworks (nMOFs) incorporating porphyrins, chlorins, bacteriochlorins have emerged as one the most prominent photoactive materials for tumor PDT. These nMOFs could enhance water solubility, stability loading efficiency photosensitizers (PSs). Their highly ordered porous structure facilitates O2 diffusion enhances generation 1O2 from hydrophobic bacteriochlorins, thereby improving their efficacy phototherapy. This review provides insights into PDT effects derived bacteriochlorins. It overviews design strategies, types reactive oxygen species (ROS), ROS efficiency, unique biological processes involved in inhibiting cell proliferation, focusing on mechanism by which molecular leads enhanced photochemical properties. Finally, highlights new possibilities offered bacteriochlorins-based PDT, emphasizing how optimized can further improve bioapplication porphyrin derivatives represented PSs. With ongoing research technological advancements, we anticipate that this will garner increased scientific researchers toward porphyrin-based nMOFs, elevating potential a approach treatment malignant tumors.

Язык: Английский

Процитировано

1

Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy DOI Creative Commons
Yutao Zou,

Junjie Wu,

Qiuyun Zhang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 4, 2024

Porphyrins-based nanoscale metal-organic frameworks (nMOFs) has been widely utilized to kills tumor cells by generating cytotoxic reactive oxygen species (ROS). However, porphyrin based nMOFs (por-nMOFs) still face challenges such as rapid immune clearance and weak targeting. Researchers have discovered that using a top-down biomimetic strategy, where are coated with cell membranes, can promote long blood circulation, evade the reticuloendothelial system, improve cancer targeting, thereby significantly enhancing photodynamic therapy (PDT) effect of nMOFs. This review summarizes recent work on different membranes-coated por-nMOFs for enhanced PDT. details changes in physicochemical properties, homotypic cell-selective endocytosis, improved tissue increased cytotoxicity effective vivo suppression after wrapped membranes. Additionally, this compares biological functions various types including red aptamer-modified hybrid membranes from fusion cells. The highlights immunogenic death function when derived By summarizing augmented PDT effects combined antitumor outcomes other therapeutic modalities, aims provide new insights into biomedical applications offer more references preclinical application porphyrin-based photosensitizers.

Язык: Английский

Процитировано

5

Metal–organic frameworks as nanoplatforms for combination therapy in cancer treatment DOI
Zainab Lafi, Sina M. Matalqah,

Ebaa Abu-Saleem

и другие.

Medical Oncology, Год журнала: 2024, Номер 42(1)

Опубликована: Дек. 9, 2024

Язык: Английский

Процитировано

4

Recent Advances in Glutathione Depletion-Enhanced Porphyrin-Based nMOFs for Photodynamic Therapy DOI Creative Commons
Bin Gong, Qiuyun Zhang, Jiayi Chen

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 244 - 244

Опубликована: Фев. 12, 2025

Photodynamic therapy has established itself as a clinical treatment for certain superficial cancers by converting oxygen into cytotoxic singlet to eradicate cancer cells. Porphyrin-based nanoscale metal-organic frameworks have emerged promising photosensitive platforms due their ability prevent the hydrophobic aggregation quenching of porphyrin molecules and enhance accumulation at tumor site, thereby becoming focal point in photodynamic materials research. However, elevated levels glutathione other reductive substances within cells can alleviate oxidative stress induced from process, thus protecting intracellular biomolecular structures damage. Consequently, it is crucial design functionalized nanoplatforms that integrate depletion with porphyrin-based significantly boost efficacy. Moreover, excess disrupt structure frameworks, which not only increases capacity generate upon light exposure but also aids recovery fluorescence imaging capabilities. Additionally, this specificity minimizes photosensitizing harm normal tissues. This review compiles recent advancements developing enhanced phototherapy through depletion. It aims promote further application provide valuable insights preclinical applications. By highlighting strategies improve therapeutic outcomes while maintaining safety profiles, summary seeks advance development more effective targeted treatments.

Язык: Английский

Процитировано

0

A Porphyrin-Based Metal–Organic Framework as a Photosensitizer for Singlet Oxygen Generation and Photocatalytic Water Treatment DOI
Behrang Salahshournia, Ali Noroozi, Daniel Fortin

и другие.

ACS Applied Optical Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Язык: Английский

Процитировано

0

Metal-organic frameworks-loaded indocyanine green for enhanced phototherapy: a comprehensive review DOI Creative Commons
Yutao Zou, Qiuyun Zhang, Jiayi Chen

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Май 27, 2025

Indocyanine green (ICG) is a small molecule approved by the U.S. Food and Drug Administration (FDA) for liver function imaging angiography. ICG can be used not only near-infrared but also photodynamic photothermal therapy. However, hydrophilicity of leads to relatively short blood circulation time, it easily cleared organs such as liver. Moreover, lacks targeting ability diseased sites. By using natural porous metal-organic frameworks (MOFs) carrier, high-efficiency loading achieved, which has significantly broadened its biomedical applications. This review comprehensively summarizes research work in recent years regarding utilization MOF carrier load bioapplication malignant cancer inhibition, antibacterial treatment, treatment Alzheimer’s disease. It focuses on summarizing design concepts different types carriers molecules. Meanwhile, emphasizes enhanced therapeutic effects achieved when multiple modalities realized through post-modification are combined with ICG-mediated phototherapy. expected that summary this review, applications field disease further promoted.

Язык: Английский

Процитировано

0

Recent Advances in Porphyrin-Based Covalent Organic Frameworks for Synergistic Photodynamic and Photothermal Therapy DOI Creative Commons
Qi Cheng, Jiayi Chen, Yingli Qu

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(12), С. 1625 - 1625

Опубликована: Дек. 22, 2024

Porphyrin’s excellent biocompatibility and modifiability make it a widely studied photoactive material. However, its large π-bond conjugated structure leads to aggregation precipitation in physiological solutions, limiting the biomedical applications of porphyrin-based materials. It has been demonstrated through research that fabricating porphyrin molecules into nanoscale covalent organic frameworks (COFs) structures can circumvent issues such as poor dispersibility resulting from hydrophobicity, thereby significantly augmenting photoactivity Porphyrin-based COF materials exert combined photodynamic photothermal effects, circumventing limitations therapy (PDT) due hypoxia (PTT) heat shock proteins or adverse impact excessive on protein activity normal tissue. Furthermore, porous COFs facilitates circulation oxygen reactive species promotes sufficient contact with lesion site for therapeutic functions. This review covers recent progress regarding treating malignant tumors venous thrombosis antibacterial anti-inflammatory uses via PDT PTT. By summarizing relevant design strategies, ranging molecular functional application, this provides reference basis enhanced phototherapy application aims offer valuable insights more effective synthesis existing experimental data, paving way their future preclinical utilization.

Язык: Английский

Процитировано

2