Recent Advances in Porphyrin-Based Covalent Organic Frameworks for Synergistic Photodynamic and Photothermal Therapy DOI Creative Commons
Qi Cheng, Jiayi Chen, Yingli Qu

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1625 - 1625

Published: Dec. 22, 2024

Porphyrin’s excellent biocompatibility and modifiability make it a widely studied photoactive material. However, its large π-bond conjugated structure leads to aggregation precipitation in physiological solutions, limiting the biomedical applications of porphyrin-based materials. It has been demonstrated through research that fabricating porphyrin molecules into nanoscale covalent organic frameworks (COFs) structures can circumvent issues such as poor dispersibility resulting from hydrophobicity, thereby significantly augmenting photoactivity Porphyrin-based COF materials exert combined photodynamic photothermal effects, circumventing limitations therapy (PDT) due hypoxia (PTT) heat shock proteins or adverse impact excessive on protein activity normal tissue. Furthermore, porous COFs facilitates circulation oxygen reactive species promotes sufficient contact with lesion site for therapeutic functions. This review covers recent progress regarding treating malignant tumors venous thrombosis antibacterial anti-inflammatory uses via PDT PTT. By summarizing relevant design strategies, ranging molecular functional application, this provides reference basis enhanced phototherapy application aims offer valuable insights more effective synthesis existing experimental data, paving way their future preclinical utilization.

Language: Английский

Recent Advances in Glutathione Depletion-Enhanced Porphyrin-Based nMOFs for Photodynamic Therapy DOI Creative Commons
Bin Gong, Qiuyun Zhang, Jiayi Chen

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 244 - 244

Published: Feb. 12, 2025

Photodynamic therapy has established itself as a clinical treatment for certain superficial cancers by converting oxygen into cytotoxic singlet to eradicate cancer cells. Porphyrin-based nanoscale metal-organic frameworks have emerged promising photosensitive platforms due their ability prevent the hydrophobic aggregation quenching of porphyrin molecules and enhance accumulation at tumor site, thereby becoming focal point in photodynamic materials research. However, elevated levels glutathione other reductive substances within cells can alleviate oxidative stress induced from process, thus protecting intracellular biomolecular structures damage. Consequently, it is crucial design functionalized nanoplatforms that integrate depletion with porphyrin-based significantly boost efficacy. Moreover, excess disrupt structure frameworks, which not only increases capacity generate upon light exposure but also aids recovery fluorescence imaging capabilities. Additionally, this specificity minimizes photosensitizing harm normal tissues. This review compiles recent advancements developing enhanced phototherapy through depletion. It aims promote further application provide valuable insights preclinical applications. By highlighting strategies improve therapeutic outcomes while maintaining safety profiles, summary seeks advance development more effective targeted treatments.

Language: Английский

Citations

0
Evolution of nMOFs in photodynamic therapy: from porphyrins to chlorins and bacteriochlorins for better efficacy DOI Creative Commons
Yutao Zou, Jiayi Chen, Yingli Qu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Photodynamic therapy (PDT) has gained significant attention due to its non-invasive nature, low cost, and ease of operation. Nanoscale metal-organic frameworks (nMOFs) incorporating porphyrins, chlorins, bacteriochlorins have emerged as one the most prominent photoactive materials for tumor PDT. These nMOFs could enhance water solubility, stability loading efficiency photosensitizers (PSs). Their highly ordered porous structure facilitates O2 diffusion enhances generation 1O2 from hydrophobic bacteriochlorins, thereby improving their efficacy phototherapy. This review provides insights into PDT effects derived bacteriochlorins. It overviews design strategies, types reactive oxygen species (ROS), ROS efficiency, unique biological processes involved in inhibiting cell proliferation, focusing on mechanism by which molecular leads enhanced photochemical properties. Finally, highlights new possibilities offered bacteriochlorins-based PDT, emphasizing how optimized can further improve bioapplication porphyrin derivatives represented PSs. With ongoing research technological advancements, we anticipate that this will garner increased scientific researchers toward porphyrin-based nMOFs, elevating potential a approach treatment malignant tumors.

Language: Английский

Citations

0
Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy DOI Creative Commons
Yutao Zou,

Junjie Wu,

Qiuyun Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 4, 2024

Porphyrins-based nanoscale metal-organic frameworks (nMOFs) has been widely utilized to kills tumor cells by generating cytotoxic reactive oxygen species (ROS). However, porphyrin based nMOFs (por-nMOFs) still face challenges such as rapid immune clearance and weak targeting. Researchers have discovered that using a top-down biomimetic strategy, where are coated with cell membranes, can promote long blood circulation, evade the reticuloendothelial system, improve cancer targeting, thereby significantly enhancing photodynamic therapy (PDT) effect of nMOFs. This review summarizes recent work on different membranes-coated por-nMOFs for enhanced PDT. details changes in physicochemical properties, homotypic cell-selective endocytosis, improved tissue increased cytotoxicity effective vivo suppression after wrapped membranes. Additionally, this compares biological functions various types including red aptamer-modified hybrid membranes from fusion cells. The highlights immunogenic death function when derived By summarizing augmented PDT effects combined antitumor outcomes other therapeutic modalities, aims provide new insights into biomedical applications offer more references preclinical application porphyrin-based photosensitizers.

Language: Английский

Citations

3
Metal–organic frameworks as nanoplatforms for combination therapy in cancer treatment DOI
Zainab Lafi, Sina M. Matalqah,

Ebaa Abu-Saleem

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 42(1)

Published: Dec. 9, 2024

Language: Английский

Citations

3
Recent Advances in Porphyrin-Based Covalent Organic Frameworks for Synergistic Photodynamic and Photothermal Therapy DOI Creative Commons
Qi Cheng, Jiayi Chen, Yingli Qu

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1625 - 1625

Published: Dec. 22, 2024

Porphyrin’s excellent biocompatibility and modifiability make it a widely studied photoactive material. However, its large π-bond conjugated structure leads to aggregation precipitation in physiological solutions, limiting the biomedical applications of porphyrin-based materials. It has been demonstrated through research that fabricating porphyrin molecules into nanoscale covalent organic frameworks (COFs) structures can circumvent issues such as poor dispersibility resulting from hydrophobicity, thereby significantly augmenting photoactivity Porphyrin-based COF materials exert combined photodynamic photothermal effects, circumventing limitations therapy (PDT) due hypoxia (PTT) heat shock proteins or adverse impact excessive on protein activity normal tissue. Furthermore, porous COFs facilitates circulation oxygen reactive species promotes sufficient contact with lesion site for therapeutic functions. This review covers recent progress regarding treating malignant tumors venous thrombosis antibacterial anti-inflammatory uses via PDT PTT. By summarizing relevant design strategies, ranging molecular functional application, this provides reference basis enhanced phototherapy application aims offer valuable insights more effective synthesis existing experimental data, paving way their future preclinical utilization.

Language: Английский

Citations

2