An Imidazole Functionalized Hf(IV) Metal–Organic Framework for Multi‐Component Biginelli and Hantzsch Condensation Reactions and Fluorometric Sensing of Anticancer Drug Raloxifene

Chemistry - An Asian Journal, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

Abstract The growing global population and rising demand for pharmaceuticals highlight the need efficient drug synthesis detection methods. This study presents a bifunctional imidazole‐functionalized Hf(IV)‐based metal–organic framework (MOF), 1 as heterogeneous catalyst synthesizing 1,4‐dihydropyridines (1,4‐DHPs), which are key moieties in of drugs used cardiovascular treatments. solvent‐free activated form , labeled 1′ catalyzes both Biginelli Hantzsch reactions under mild conditions. reaction using aldehyde, ethyl acetoacetate, urea proceeded at 80 °C 0.5 h with 99% yield, while ammonium acetate occurred room temperature ethanol within h, also achieving yield. Compound showed broad substrate compatibility reactions. Additionally, MOF exhibited excellent sensing ability anticancer raloxifene (RLX), showing fast turn‐off fluorescence response (within 5 s), low limit (9 nM), high Stern–Volmer constant (K sv 2 × 10 6 M⁻¹), enabling sensitive diverse environments, including wastewater biofluids. Detailed investigations into catalytic mechanisms capabilities provide valuable insights advancing analytical methodologies. provides demonstrating its potential advanced pharmaceutical real‐time monitoring.

Язык: Английский

Coordinatively Unsaturated Structurally Diverse Homophthalate-Based Cobalt(II) Coordination Polymers for Efficient Multicomponent Catalysis

Crystal Growth & Design, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 17, 2024

Coordination polymers (CPs) have emerged as pioneering compounds due to their diverse structural features and tunable properties. Numerous advantages, along with thermal chemical stability, make CPs promising materials for various applications, preferably in catalysis. Herein, four [Co(4-ABPT)(HPA)(H2O)], SSICG-8; [Co(4-ABPT)(HPA)(H2O)]·4H2O, SSICG-9; [Co(BPY)(HPA)(H2O)(CH3OH)], SSICG-10; [Co(4-ABPT) (HHPA)2]·H2O, SSICG-16 (SSICG stands solid-state inorganic chemistry group, 4-ABPT = 3,5-di(pyridine-4-yl)-4H-1,2,4-triazol-4-amine, H2HPA homophthalic acid, BPY 4,4′-bipyridine) been synthesized via the hydrothermal synthetic methodology. SSICG-8 showcases a 4,4-net topology Schläfli symbol of 44.62, while SSICG-10 displays 3,3-net topology. we tuned catalytic performance by tuning Lewis acidic open metal sites (OMSs), basic sites, porosity compounds. Activated SSICG-9 (OMSs) free amine pyridyl groups. The presence high-density OMSs, groups, makes an efficient catalyst, whereas lacks porosity, OMSs. These were clearly visible observed efficiency order < SSICG-9. most SSICG-9, was employed synthesize Nemadipine B (1,4-dihydropyridine-based drug) 95% yield at 60 °C, using only 1.5 mol % within 4 h ethanol. This study presents systematic strategy synthesizing coordination showcasing efficacy catalysis under mild environmentally friendly conditions.

Язык: Английский

Stoichiometry-Regulated Synthesis of Three Adenine-Based Coordination Polymers for Catalytic Excellence through the Synergistic Amalgamation of Coordinative Unsaturation and Lewis Basic Sites

Inorganic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Nucleobase adenine is a promising candidate for synthesizing fascinating coordination polymers (CPs) due to the presence of five potential metal-ion binding centers. In recent years, CPs have emerged as Lewis acid-base centers containing heterogeneous catalysts wide range organic transformations. However, crucial role stoichiometric regulations starting materials and their consequential impact on catalytic performance are rarely studied. Herein, we synthesized three (Ad)-based cadmium with 5-nitro isophthalic acid (H

Язык: Английский