Organic Letters,
Год журнала:
2024,
Номер
26(51), С. 11105 - 11110
Опубликована: Дек. 16, 2024
1,3-Dienes
are
versatile
raw
materials
for
building
molecular
complexity.
We
report
herein
mild
conditions
the
regio-
and
stereoselective
[only
(E)
isomer
obtained]
1,4-carboalkoxylation
of
1,3-dienes.
This
electrochemical
multicomponent
reaction
provides
an
eco-efficient
straightforward
access
to
a
diverse
range
(E)-polyfunctionalized
allyl
ether
products,
without
requiring
any
metal
catalyst.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(18), С. 5278 - 5305
Опубликована: Янв. 1, 2024
This
review
summarizes
the
latest
methodological
advances
in
photocatalytic
C(sp
3
)–H
functionalization,
with
a
particular
emphasis
on
formation
of
C–P,
C–B,
C–S
bonds,
etc
.,
and
some
prominent
efforts
asymmetric
C–H
functionalization.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(10), С. 2352 - 2362
Опубликована: Апрель 5, 2024
Abstract
While
the
emergence
of
electrophotochemistry
provides
opportunities,
such
a
chemistry
at
this
stage
suffers
from
limited
reaction
types
and
high
photocatalyst
loadings.
A
self‐catalyzed
electrophotosynthesis
as
well
one
with
low
loading
is
presented.
These
external‐oxidant‐free
cyclizations
are
enabling
applicable
to
range
activated
alkenes,
affording
diverse
array
thiocyanato
heterocycles
including
4‐pyrrolin‐2‐ones,
isoquinoline‐1,3‐diones,
indolo[2,1‐
]isoquinolin‐6(5
H
)‐ones,
benzoimidazo[2,1‐
)‐ones
indolin‐2‐ones,
protocols
amenable
late‐stage
diversification
complex
molecular
architectures
gram‐scale
syntheses.
Sunlight
could
serve
light
source,
be
conducted
in
an
all‐solar‐driven
mode
using
commercially
available
photovoltaic
panel
produce
electricity.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(36)
Опубликована: Апрель 23, 2024
Three
hybrid
electrochemical
protocols,
which
involve
the
energy
transfer,
direct
photolysis
and
N-hydroxyphthalimide
catalyst,
respectively,
are
presented
for
selenylation/cyclization
of
fragile
substrates
3-aza-1,5-dienes
with
diorganyl
diselenides
to
afford
3-selenomethyl-4-pyrrolin-2-ones.
The
two
electrophotocatalytic
reactions
indirect
electrolysis
one
both
regioselective
external-oxidant-
transition-metal-free,
associated
a
broad
substrate
scope
high
Se-economy,
all
three
methods
amenable
gram-scale
syntheses,
late-stage
functionalizations,
sunlight-induced
experiments
all-solar-driven
syntheses.
ACS Synthetic Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Malonic
acid
(MA)
is
a
high-value
chemical
with
diverse
applications
in
the
fields
of
food,
agriculture,
medicine,
and
synthesis.
Despite
successful
biosynthesis
MA
has
been
performed
Escherichia
coli,
Myceliophthora
thermophila,
Saccharomyces
cerevisiae,
resulting
titers
remain
insufficient
for
industrial-scale
production.
In
this
study,
three
distinct
metabolic
pathways
were
designed
constructed
to
increase
production
E.
coli.
Among
these,
fumaric
pathway
comprising
four
key
enzymes
including
aspartase
(AspA),
decarboxylase
(PanD),
β-alanine-pyruvate
transaminase
(Pa0132),
succinic
aldehyde
dehydrogenase
(YneI)
was
identified
as
most
effective
Additionally,
supplementation
found
significantly
improve
To
further
enhance
production,
engineering
strategies
employed,
deletion
ydfG
gene,
responsible
encoding
malonic
semialdehyde
reductase,
ptsG
which
encodes
glucose
transporter.
Finally,
through
optimization
fermentation
conditions
feeding
strategies,
engineered
strain
achieved
an
titer
1.4
g/L
shake
flask
17.8
fed-batch
fermentation.
This
study
provides
new
insights
into
utilizing
metabolically
coli
cells.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(19), С. 5553 - 5557
Опубликована: Янв. 1, 2024
A
mild
and
efficient
protocol
for
preparing
4-halomethyl
benzoxazines
via
a
photoelectrochemical
process
with
ammonium
halide
as
the
halogenating
reagent
was
developed.
Chemical Communications,
Год журнала:
2024,
Номер
60(62), С. 8119 - 8122
Опубликована: Янв. 1, 2024
A
novel
visible-light
promoted
metal-free
radical
cascade
cyclization
reaction
has
been
developed
with
3-allyl-2-arylquinazolinones
as
a
new
class
of
acceptor.
This
photocatalytic
protocol
represents
an
efficient
approach
to
construct
phosphorylated
dihydroisoquinolino[1,2-
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(19), С. 5564 - 5572
Опубликована: Янв. 1, 2024
This
study
reports
the
electrochemical
reaction
of
vinylcyclopropanes
with
sulfonyl
chlorides,
resulting
in
1,5-hydrosulfonylation
and
1,5-chlorosulfonylation.
New
photochemical
approaches
to
2,3-fused
quinazolinones
and
dihydroquinazolinones
are
disclosed.
The
intramolecular
hydrocyclization
proceeds
in
moderate
excellent
yields
across
diverse
alkenes
with
high
regioselectivity
diastereocontrol.
Mechanistic
studies
indicated
that
the
radical
cascade
processes
involve
thiophenol
acting
as
single-electron
transfer
hydrogen
atom
reagents.
success
of
gram-scale
synthesis
proves
strategy
can
be
used
for
practical
applications.
