Electrospinning in Drug Delivery: Progress and Future Outlook
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 20, 2025
Abstract
There
is
intense
research
during
the
past
few
decades
to
design
and
fabricate
drug
delivery
systems
using
electrospinning
system.
Electrospinning
an
efficient
technique
produce
nanofiber
materials
with
different
dimensions
morphologies
by
adjusting
processing
parameters.
becoming
innovative
technology
that
promotes
pursuit
maintenance
of
human
health.
Herein,
review
discusses
contribution
in
systems,
summarising
modification
various
system
configurations
effects
process
parameters
on
fibers,
their
application
including
carrier
materials,
loaded
drugs
release
mechanisms
illustrates
medical
applications.
Finally,
this
challenges,
bottlenecks,
development
prospects
field
terms
scaling
up
for
clinical
use
exploring
potential
solutions
pave
way
establish
future
systems.
Язык: Английский
Synergistic Enhancement of Carboplatin Efficacy through pH-Sensitive Nanoparticles Formulated Using Naturally Derived Boswellia Extract for Colorectal Cancer Therapy
Pharmaceutics,
Год журнала:
2024,
Номер
16(10), С. 1282 - 1282
Опубликована: Сен. 30, 2024
Carboplatin
(Cp)
is
a
potent
chemotherapeutic
agent,
but
its
effectiveness
constrained
by
associated
side
effects.
Frankincense,
an
oleo-gum
resin
from
the
Язык: Английский
Nano/Micro-Enabled Modification and Innovation of Conventional Adjuvants for Next-Generation Vaccines
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(5), С. 185 - 185
Опубликована: Май 19, 2025
The
global
spread
of
infectious
diseases
has
raised
public
awareness
vaccines,
highlighting
their
essential
role
in
protecting
health.
Among
the
components
modern
adjuvants
have
received
increasing
attention
for
boosting
immune
responses
and
enhancing
efficacy.
Recent
advancements
adjuvant
research,
particularly
nanodelivery
systems,
paved
way
developing
more
effective
safer
adjuvants.
This
review
outlines
properties,
progress,
mechanisms
FDA-approved
conventional
adjuvants,
focusing
on
contributions
to
challenges
vaccine
success.
Despite
these
advancements,
still
face
suboptimal
immunomodulatory
effects,
potential
side
limitations
targeting
specific
pathways.
Nanodelivery
systems
emerged
as
a
transformative
approach
design,
offering
unique
advantages
such
stability,
enabling
controlled
antigen
release,
inducing
responses.
By
addressing
limitations,
nanocarriers
improve
safety
efficacy
drive
development
next-generation
complex
diseases.
also
explores
strategies
incorporating
into
development,
emphasizing
its
optimizing
formulations.
summarizing
current
recent
advances,
this
aims
provide
valuable
insights
guiding
future
efforts
designing
innovative
that
meet
evolving
needs
immunization
programs.
Язык: Английский
Sustainable Nanomedicine: Enhancement of Asplatin’s Cytotoxicity In Vitro and In Vivo Using Green-Synthesized Zinc Oxide Nanoparticles Formed via Microwave-Assisted and Gambogic Acid-Mediated Processes
Molecules,
Год журнала:
2024,
Номер
29(22), С. 5327 - 5327
Опубликована: Ноя. 12, 2024
Chemoresistance
encountered
using
conventional
chemotherapy
demands
novel
treatment
approaches.
Asplatin
(Asp),
a
platinum
(IV)
prodrug
designed
to
release
cisplatin
and
aspirin
in
reductive
environment,
has
demonstrated
high
cytotoxicity
at
reduced
drug
resistance.
Herein,
we
investigated
the
ability
of
green-synthesized
nanocarriers
enhance
Asp’s
efficacy.
Zinc
oxide
nanoparticles
(ZnO-NPs)
were
synthesized
green
microwave-assisted
method
with
reducing
capping
agent
gambogic
acid
(GA).
These
then
loaded
Asp,
yielding
Asp@ZnO-NPs.
Transmission
electron
microscopy
was
utilized
study
morphological
features
ZnO-NPs.
Cell
viability
studies
conducted
on
MDA-MB-231
breast
cancer
cells
Asp@ZnO-NPs
significantly
decrease
half-maximal
inhibitory
concentration
(IC50)
(5
±
1
µg/mL).
This
further
flow
cytometric
analysis
that
revealed
capacity
increase
late
apoptotic
fractions.
Furthermore,
vivo
carried
out
solid
Ehrlich
carcinoma-bearing
mice
showed
significant
tumor
volume
reduction
(156.3
7.6
mm3),
compared
Asp
alone
(202.3
8.4
mm3)
untreated
controls
(342.6
10.3
mm3).
The
histopathological
increased
necrosis
Asp@ZnO-NPs-treated
group.
Asp@ZnO-NPs,
an
eco-friendly
approach,
enhanced
anticancer
activity,
offering
sustainable
solution
for
potent
formulations.
Язык: Английский
Preparation and Characterization of Tiamulin-Loaded Niosomes for Oral Bioavailability Enhancement in Mycoplasma-Infected Broilers
Micro,
Год журнала:
2024,
Номер
4(4), С. 734 - 750
Опубликована: Ноя. 27, 2024
Mycoplasma
infections
pose
significant
challenges
in
the
poultry
industry,
necessitating
effective
therapeutic
interventions.
Tiamulin,
a
veterinary
antibiotic,
has
demonstrated
efficacy
against
species.
However,
emergence
of
resistant
species
could
dramatically
reduce
potential,
contributing
to
economic
losses.
Optimizing
tiamulin’s
pharmacokinetic
profile
via
nanocarrier
incorporation
enhance
its
potential
and
administration
frequency,
ultimately
reducing
strain
emergence.
Niosomes,
type
self-assembled
non-ionic
surfactant-based
nanocarrier,
have
emerged
as
promising
drug
delivery
system,
offering
improved
stability,
sustained
release,
enhanced
bioavailability.
In
this
study,
niosomal
nanocarriers
encapsulating
tiamulin
were
prepared,
characterized
assessed
Mycoplasma-inoculated
broilers
following
oral
administration.
Differential
scanning
colorimetry
(DSC)
confirmed
alterations
crystalline
state
components
integration
into
structures
formed
during
formulation
procedure.
Transmission
electron
microscopy
(TEM)
showed
spherical
nanostructure
niosomes.
The
formulated
exhibited
zeta
average
hydrodynamic
diameter
−10.65
±
1.37
mV
339.67
30.88
nm,
respectively.
Assessment
parameters
gallisepticum-infected
revealed
ability
increase
bioavailability
systemic
exposure,
marked
by
significantly
higher
area
under
curve
(AUC)
(p
<
0.01)
prolonged
elimination
half-life
(T1/2)
0.05).
Enhanced
residence
time
are
crucial
factors
maintaining
concentrations
at
reduced
doses
frequencies.
This
approach
provides
viable
strategy
decrease
risk
subtherapeutic
levels,
thereby
mitigating
development
antibiotic
resistance.
findings
presented
herein
offer
sustainable
for
efficient
use
antibiotics
medicine.
Язык: Английский