Synthetic aspects, structural insights and pharmacological potential of pyrazole derivatives: an overview

Deleted Journal, Год журнала: 2025, Номер 7(2)

Опубликована: Фев. 13, 2025

Abstract There is an increase in infectious diseases every year. Heterocyclic compounds have been use as drugs for a long time. Amongst many heterocyclic derivatives, the containing pyrazole core has limelight because of its relative ease synthesis and excellent biological activities. Pyrazoles are aromatic consisting ring structure where two nitrogen atoms adjacent to each other contain three carbon atoms. Over years pyrazoles explored variety pharmacological applications. Herein, this review overviews information related industrially important pyrazoline scaffolds their applications, recent literature on synthesizing providing explanation activity by focusing structural relationship hence affording ideas design scaffolds. Graphical abstract

Язык: Английский

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Regioselective Pyrazole Synthesis via Base-Mediated [3+2] Cycloaddition of 2-Alkynyl-1,3-Dithianes and Sydnones

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

We present a novel base-mediated [3+2] cycloaddition for the regioselective synthesis of polysubstituted pyrazoles using 2-alkynyl-1,3-dithianes and sydnones. By exploiting umpolung nucleophilic properties 2-alkynyl-1,3-dithianes, this method achieves efficient pyrazole construction under mild conditions with excellent regioselectivity, broad functional group tolerance, diverse substrate compatibility. Furthermore, unique reactivity dithianyl enables facile derivatization highly functionalized pyrazoles.

Язык: Английский

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Antibacterial and Antifungal Pyrazoles Based on Different Construction Strategies

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 282, С. 117081 - 117081

Опубликована: Ноя. 20, 2024

Язык: Английский

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Anti-inflammatory and antioxidant succinyl-chitosan oligosaccharide protects human epidermal cell and mouse skin against ultraviolet B-induced photodamage

Carbohydrate Polymers, Год журнала: 2024, Номер 351, С. 123102 - 123102

Опубликована: Дек. 3, 2024

Язык: Английский

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