Development of novel Paullone-based PROTACs as Anticancer agents DOI

Manda Srinivas,

Vamsee Krishna Chatakonda,

Vinod G. Ugale

и другие.

Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 141273 - 141273

Опубликована: Дек. 1, 2024

Язык: Английский

Antioxidant, and enzyme inhibition effects of chia (Salvia hispanica) seed oil: A comprehensive phytochemical screening using LC-HR/MS DOI Creative Commons

Muzaffer Mutlu,

Zeynebe Bingöl,

Eda Mehtap Özden

и другие.

Electronic Journal of Biotechnology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Discovery of a novel 4-pyridyl SLC-0111 analog targeting tumor-associated carbonic anhydrase isoform IX through tail-based design approach with potent anticancer activity DOI Creative Commons
Hamada H. H. Mohammed,

Sherif A. Abdel‐Fattah,

Hesham M. Hassan

и другие.

Frontiers in Chemistry, Год журнала: 2025, Номер 13

Опубликована: Апрель 4, 2025

Introduction: Carbonic anhydrase IX (CA IX) is a tumor-associated enzyme involved in cancer progression and survival. Targeting CA with selective inhibitors like SLC-0111 has shown therapeutic potential. This study aimed to develop novel 4-pyridyl analog ( Pyr ) of enhanced anticancer activity. Methods: was synthesized using tail-based design characterized by NMR. Its cytotoxicity tested against normal cell lines. inhibition, cycle effects, apoptosis induction, protein expression changes were evaluated. Molecular docking ADMET predictions assessed binding drug-like properties. Results Discussion: showed toward cells potent inhibition. It induced G0/G1 arrest, apoptosis, modulated p53, Bax, Bcl-2 levels. Docking confirmed strong binding, analysis indicated good oral bioavailability. These results support as promising candidate.

Язык: Английский

Процитировано

0
Some Novel Oxirane-Thiirane Derivatives: Synthesis, Molecular docking and Enzymatic Inhibition for Therapeutic Potential DOI
Vagif Farzaliyev, Adem Ertürk,

A.T. Huseynova

и другие.

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Язык: Английский

Процитировано

0
Computer aided design of CGA-N9 derived peptides based on oligopeptide transporters and their antifungal evaluations DOI
Yan Fu, Yiqing Sun, Shaojie Zhang

и другие.

Bioorganic Chemistry, Год журнала: 2025, Номер 160, С. 108485 - 108485

Опубликована: Апрель 17, 2025

Язык: Английский

Процитировано

0
Comprehensive Insights into Carbonic Anhydrase Inhibition: A Triad of In vitro, In silico, and In vivo Perspectives DOI
Ahmed A. Allam, Hassan A. Rudayni, Noha Ahmed

и другие.

Enzyme and Microbial Technology, Год журнала: 2025, Номер 189, С. 110657 - 110657

Опубликована: Апрель 17, 2025

Язык: Английский

Процитировано

0
Development of novel Paullone-based PROTACs as Anticancer agents DOI

Manda Srinivas,

Vamsee Krishna Chatakonda,

Vinod G. Ugale

и другие.

Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 141273 - 141273

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

0